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Wilson Geisler, Director SEA 4.328A, Mailcode A8000, Austin, TX 78712 • 512-471-5380

Nace Golding

Associate Professor

Nace Golding

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Biography

In order for us to interpret the outside world, neurons in the brain must detect and convey different aspects of sensory stimuli embedded within complex patterns of synaptic input. Sensitivity to these sensory features is conferred not only by the synaptic connectivity of neurons, but also from the properties of their dendrites, the tree-like structures along which synaptic activity propagates to the site of action potential generation in the axon. Dendrites contain diverse subtypes of voltage- and ligand-gated ion channels, which distort the amplitude and time course of synaptic activity. In this way, the dendrites actively regulate what aspects of sensory information are ultimately communicated to the neuron’s network targets.
The focus of my laboratory is to identify the cellular mechanisms by which dendrites transform the synaptic activity they receive into new patterns of action potential firing. We are examining this question in neurons of the mammalian central auditory system, where an understanding of synaptic integration in single cells bears directly on the broader question of how the brain detects different features of sound that in turn are critical for diverse processes such as speech perception and sound localization.
We use dendritic patch-pipette recordings and optical imaging techniques in living brain slices to study the distribution, biophysical properties, modulation and functional significance of ion channels in single neurons. In addition, imaging techniques and multiple simultaneous recordings of connected neurons are being used to examine how synaptic information is processed in auditory circuits.

Publications

Khurana, S.*, Remme, M.*, Rinzel, J.R., and Golding, N.L. (2011). Dynamic interaction of Ih and IK-LVA stabilizes high frequency synaptic excitation in principal neurons of the medial superior olive. Journal of Neuroscience, 31:8936-8947. PDF       * designates equal contributions

Scott, L.L., Mathews, P.J., and Golding, N.L. (2010). Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive. Journal of Neuroscience, 30(6):2039 –2050. PDF

Mathews, P.J., Jercog, P.E., Rinzel, J.R., Scott, L.L., and Golding, N.L. (2010). Control of submillisecond timing in binaural coincidence detectors via a somatically directed gradient of Kv1 channels. Nature Neuroscience, 13:601-609. PDF

Scott, L.L., Hage, T.A., and Golding, N.L. (2007). Weak action potential backpropagation is associated with high frequency axonal firing capability in principal neurons of the medial superior olive. Journal of Physiology (Lond), 583.2:647-661. PDF

Golding, N.L., Mickus, T., Katz, Y., Kath, W., and Spruston, N. (2005) Factors mediating powerful voltage attenuation along CA1 dendrites. Journal of Physiology (Lond), 568.1:69-82. PDF

Scott, L.L., Mathews, P.M., Golding, N.L. (2005) Post-hearing developmental refinement of temporal processing in  principal neurons of the medial superior olive. Journal of Neuroscience, 25:7887-7895. PDF  

Scott, L.L., Mathews, P.M., Golding, N.L. (2005) Post-hearing developmental refinement of temporal processing in  principal neurons of the medial superior olive. Journal of Neuroscience, 25:7887-7895. PDF

Golding, N.L., Staff, N.S., and Spruston, N. (2002) Dendritic spikes as a mechanism for cooperative long-term potentiation. Nature, 418:326-331. PDF

Golding, N.L., Kath, W.L., and Spruston, N. (2001) Dichotomy of action potential backpropagation in CA1 pyramidal neuron dendrites. Journal of Neurophysiology,86:2998-3010. PDF

Golding, N.L., Jung, H., Mickus, T., and Spruston, N. (1999) Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. Journal of Neuroscience, 19:8789-8798. PDF

Golding, N.L., Ferragamo, M.J., and Oertel, D. (1999) Role of intrinsic conductances underlying responses to transients in octopus cells of the cochlear nucleus. Journal of Neuroscience, 19:2897-2905.

Ferragamo, M.J., Golding, N.L., and Oertel, D. (1998) Synaptic inputs to stellate cells in the ventral cochlear nucleus. Journal of Neurophysiology, 79:51-63. PDF

Ferragamo, M.J., Golding, N.L., Gardner, S.M., and Oertel, D. (1998) Golgi cells in the superficial granule cell domain overlying the ventral cochlear nucleus. Journal of Comparative Neurology, 400:519-528. PDF

Golding, N.L., and Spruston, N. (1998) Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron, 21:1189-1200. PDF

Golding, N.L., and Oertel, D. (1997) Physiological identification of the targets of cartwheel cells in the dorsal cochlear nucleus. Journal of Neurophysiology, 78:248-260. PDF

Golding, N.L., and Oertel, D.  (1996). Context-dependent synaptic action of glycinergic and GABAergic inputs in the dorsal cochlear nucleus. Journal of Neuroscience, 16:2208-2219. PDF

Golding, N.L., Robertson, D., and Oertel, D. (1995). Recordings from slices indicate that octopus cells of the cochlear nucleus detect coincident firing of auditory nerve fibers with temporal precision Journal of Neuroscience, 15:3138-3153. PDF

Courses

Semester         Course             Unique No.            Title

2014 Spr         BIO 365L         50905                Neurobiology Laboratory

2013 Fall         Bio 365L          50865                Neurobiology Laboratory 

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