Associate Faculty — Ph. D., University of Texas at Austin
Ph.D., Chemical Engineering, University of Texas at Austin, (2002)
B.A., Human Biology, Stanford University, (1996)
NIH Postdoctoral Fellow, Microbiology & Immunology, Stanford University (2002-2004)
Packard Fellowship, David and Lucile Packard Foundation (2005)
Dreyfus New Faculty Award (2003)
National Research Service Award, NIH (2002)
Biotechnology, applied immunology, applied microbiology
Building on decades of basic research in the biological sciences, fundamental principles underlying the function of complex biological systems are being elucidated in laboratories throughout the world. Concurrently, this understanding renders biology amenable to engineering approaches – how can scientists control, predict and thus design novel biological systems?
We use genetic engineering and biochemical techniques to address issues in immune system function and dis-function, with a view to correcting or augmenting this function. This work involves design of protein molecules, production in recombinant expression systems, biophysical and biochemical analysis and, ultimately, structural analysis to visualize the molecular basis of activity.
Overall research goals:
- Control of cellular immunity through manipulation of T cell receptor interactions
- Define neutralizing epitopes in Bordetella pertussis and use this information to engineer more effective sub-unit vaccines
- Reverse engineer pathogenic strategies used by bacterial pathogens for biotechnological applications
- Apply protein engineering approaches to issues in structural biology
- Pai, J.C., Sutherland, J. and Maynard, J.A. "Progress towards recombinant anti-infective antibodies." Recent patents in anti-infective drug discovery. 4(1):1-17 (2009).
- Sivasubramanian, A., Maynard, J.A., and Gray, J.J. "Modeling the structure of mAb 14B7 bound to the anthrax protective antigen." Proteins: Structure, Function, Bioinformatics, 70(1): 218-230 (2008).
- Feng, D., Bond, C., Ely, L., Maynard, J. and Garcia, K.C. "Structural evidence of a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon.'" Nature Immunology, 8(9): 975-983 (2007).
- Maynard, J, Myhre, R., and Roy, B. "Microarrays in infection and immunity." Current Opinion in Chemical Biology. 11(3): 306-315 (2007).
- Maynard, J., Adams, E. J., Krogsgaard, M., Petersson, K., Liu, C. and Garcia K. C. "High-level bacterial secretion of ab T Cell Receptors." Journal of Immunological Methods 306: 51-67 (2005).
- Maynard, J., Petersson, K. P., Wilson, D. H., Adams, E. J., Blondelle, S. J., Boulanger, M. J., Wilson, D. B., ad Garcia, K. C. "Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity." Immunity, 22: 81-92 (2005).
- Maynard, J., Braat-Maassen, K., Leppla, S. H., Brasky, K., Patterson, J., Iverson, B., and Georgiou, G. "Protection to Anthrax Toxin Correlates with Recombinant Antibody Affinity." Nature Biotechnology, 20(6): 597-602 (2002).
- Mao, Y., Chen, J., Maynard, J., Zhang, B., and Quiocho, F. "A Novel All Helix Fold of the AP180 Amino-Terminal Domain for Phosphoinositide Binding and Clathrin Assembly in Synaptic Vesicle Endocytosis." Cell 104: 433-440 (2001).
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