Zoo 317 Heredity, Evolution and Society

Lecture 34 No text
HUMAN DIVERSITY

I. Universal polymorphisms.

II. Local polymorphisms.

III. Local disorders.

Terms

Note
Page 425: The definitions of polymorphism are somewhat off target. A locus is polymorphic if two or more alleles have frequencies greater than 1%. It is true that this is greater than can be maintained by mutation, but that is not part of the definition.

I. Many loci are polymorphic world-wide. Ca. 50% of the genes that code for enzymes are polymorphic, with somewhat lower frequencies for genes whose products have other functions. Among the best studied of the world-wide polymorphic genes are the following:

II. Some polymorphisms are limited to one or a few populations.

III. Some inherited disorders occur with high frequency only in certain populations.


Terms
 ABO blood groups  Rh blood groups  MNSs blood groups   lactase persistence 
lactose  Duffy blood groups  Diego blood groups sickle-cell anemia
G6PD deficiency Tay-Sachs disease cystic fibrosis hypertension
congenital dislocation of the hip diabetes mellitus type 2
BRCA1 BRCA2    

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last revision: 15 November 1999
owned by: Dr. Eldon Sutton