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Sport Film Series screens "The Natural"

June 20, 7-9:15 p.m.
Harry Ransom Center (HRC), Prothro Theater

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February 29, 2012
Time:1-2 p.m.
Description:Professor Luis Nieto of the Instituto Tecnológico Autónomo de México presents "Bayesian Analysis of Functional Proteomics Profiles."

Using a new type of array technology, the reverse phase protein array (RPPA), we measure time-course protein expression for a set of selected markers that are known to co-regulate biological functions in a pathway structure. To accommodate the complex dependent nature of the data, including temporal correlation and pathway dependence for the protein markers, we propose a mixed effects model with temporal and protein-specific components. We develop a sequence of random probability measures (RPM) to account for the dependence in time of the protein expression measurements. We also acknowledge the pathway dependence among proteins via a conditionally autoregressive (CAR) model. Applying our model to the RPPA data, we reveal a pathway-dependent functional profile for the set of proteins as well as marginal expression profiles over time for individual markers.
Location:McCombs School of Business (CBA) 6.420
Contact:Vicki L Keller | 512-232-0679
Sponsor:Division of Statistics & Scientific Computation
Admission:Free
Categories:Everyone, Lecture/talk, Seminar
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