Dr. Albino Bacolla PhD

Research Associate

albino

Education

University of Turin (Italy), Doctorate in Biology

1976 Spoken and Written Languages: Italian, English, French III.

 

Research Experience

2011 – Research Associate, The University of Texas at Austin (Dr. Karen M. Vasquez)
2010 – Contractor, National Institutes of Health, National Cancer Institute, Advanced Biomedical Computing Center, SAIC-Frederick, NCI-Frederick, MD (Dr. Jack R. Collins)
2008 – 2011. Research Scientist, The University of Texas MD Anderson Cancer Center, Department of Carcinogenesis, 1808 Park Rd. 1C, Smithville, TX 78957 (Dr. Karen M. Vasquez)

1992 – 2008. Senior Research Associate/Assistant Research Scientist, Institute of Biosciences & Technology, Texas A&M University, 2121 Holcombe Blvd, Houston, TX 77030 (Dr. Robert D. Wells)

1990 – 1992 Research Associate, Laboratory of Molecular Biology, Boehringer Ingelheim Pharmaceutical, Inc., Ridgefield, CT 06877 (Dr. Johanna Griffin)

1987 – 1990 Research Associate, Department of Pharmacological Sciences, State University of New York at Stony Brook, NY 11794 (Dr. Felicia Y.-H. Wu)

1986 – 1987 Biologist, Laboratory of Endocrinology, Mauriziano Hospital, Turin, Italy (Dr. Vito De Filippis)

1984 – 1986 Postdoctoral Fellow of the Commission of the European Communities, Biomolecular Engineering Programme, Université Libre de Bruxelles, IRIBHN, Brussels, Belgium, Laboratory of Molecular Biology (Dr. Gilbert Vassart)

1979 – 1984 Technical Director for the Screening of Congenital Hypothyroidism, Mauriziano Hospital, Turin, Italy (Dr. Aurelio Costa)

1976 – 1979 Fellow of the National Ministry of Internal Affairs, Center for the Study of Endemic Goiter, Turin, Italy (Dr. Aurelio Costa)

1976 Doctor of Biology, University of Turin, Italy (Thesis Advisor: Dr. Camillo Vellano, Department of Animal Biology)

Publications (as of April 2009)

Articles and Book Chapters

1. Bacolla A, Wells RD, and Vasquez KM  (2011).  DNA secondary structure.  In: Encyclopedia of Biological Chemistry (W. J. Lennarz and M. D. Lane, eds.), Elsevier, Oxford, 2nd Edition.  Under revision

2. Kolb, J., Chuzhanova, N. A., Högel, J., Vasquez, K. M., Cooper, D. N., Bacolla, A., and Hildegard Kehrer-Sawatzki, H. (2009). Cruciform-forming inverted repeats appear to have mediated many of the microinversions that distinguish the human and chimpanzee genomes. Chromosome Res. In press.

3. Chuzhanova, N. A, Chen, J.-M., Bacolla, A., Patrinos, G. P., Ferec, C., Wells, R. D., and Cooper, D. N. (2009). Gene conversion causing human inherited disease: involvement of recombination-associated motifs and non-B DNA-forming sequences in DNA breakage. Hum. Mut. In press.

4. Bacolla, A. and Wells, R. D. (2009). Non-B DNA conformations as determinants of mutagenesis and human disease. Invited review for special issue on “Intrinsic Genomic Instability from Naturally Occurring DNA Structures” (Editors: Drs. Karen Vasquez and Philip Hanawalt). Mol. Carcinog. 48, 273-285.

5. Bacolla, A., Larson, J. E., Collins, J. R., Li, J., Milosavljevic, A., Stenson, P. D., Cooper, D. N., and Wells, R. D. (2008). Abundance and length of simple repeats in vertebrate genomes are determined by their structural properties. Genome Res. 18, 1545-1553.

6. Bacolla, A., Wojciechowska, M., Kosmider, B., Larson, J. E., and Wells, R. D. (2006). The involvement of non-B DNA conformations in gross rearrangements. Review. DNA Repair 5, 1161-1170.

7. Bacolla, A., and Wells, R. D. (2006). Non-B DNA and Chromosomal Rearrangements. In: Genomic Disorders: The Genomic Basis of Disease (Eds. J. R. Lupski and P. Stankiewicz), Humana Press, Totowa, N.J. pp. 89-99.

8. Bacolla, A., Wojciechowska, M., Kosmider, B., Larson, J. E., and Wells, R. D. (2006). Gross deletions caused by long triplet repeats and other repeat sequences. In: Genetic Instabilities and Neurological Diseases (Robert. D. Wells and Tetsuo Ashizawa, Eds.), Elsevier/Academic Press, San Diego, 717-733.

9. Son, L. S., Bacolla, A., and Wells, R. D. (2006). Sticky DNA: in vivo formation in E. coli and in vitro association of long GAA•TTC tracts to generate two independent supercoiled domains. J. Mol. Biol. 360, 267-284.

10. Bacolla, A., Collins, J. R., Gold, B., Chuzhanova, N., Ming, Y., Stephens, R. M., Stefanov, S., Olsh, A., Jakupciak, J. P., Dean, M., Lempicki, R. A., Cooper, D. N., and Wells, R. D. (2006). Long homopurine•homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region. Nucleic Acids Res. 34, 2663-2675.

11. Napierala, M., Bacolla, A., and Wells, R. D. (2005). Increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences. J. Biol. Chem. 280, 37366-37376.

12. Wojciechowska, M., Bacolla, A., Larson, J. E., and Wells, R. D. (2005). The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions. J. Biol. Chem. 280, 941-952.

13. Bacolla, A., and Wells, R. D. (2004). Non-B DNA conformations, genomic rearrangements, and human disease. J. Biol. Chem. (Minireview) 279, 47411-47414.

14. Bacolla, A., and Wells, R. D. (2004). DNA Secondary Structure, in Encyclopedia of Biological Chemistry (W. J. Lennarz and M. D. Lane, eds.), Elsevier, Oxford, Vol. 1, pp. 782-787.

15. Bacolla, A., Jaworski, A., Larson, J. E., Jakupciak, J. P., Chuzhanova, N., Abeysinghe, S. S., O’Connell, C. D., Cooper, D. N., and Wells, R. D. (2004). Breakpoints of gross deletions coincide with non-B DNA conformations. Proc. Natl. Acad. Sci. U. S. A. 101, 14162-14167.

16. Bacolla, A. (2002). FMR1 Gene. Wiley Encyclopedia of Molecular Medicine, John Wiley & Sons, Inc., New York, pp. 1303-1305.

17. Bacolla, A., Jaworski, A., Timothy D. Connors, and Robert D. Wells. (2001). PKD1 unusual DNA conformations are recognized by nucleotide excision repair. J. Biol. Chem. 276, 18597-18604.

18. Bacolla, A., Pradhan, S., Larson, J. E., Roberts, R. J., and Robert D. Wells. (2001). Recombinant human DNA (cytosine-5) methyltransferase. III. Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGG•CCG sequence. J. Biol. Chem. 276, 18605-18613.

19. Pradhan, S., Bacolla, A., Wells, R.D., and Roberts, R.J. (1999). Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J. Biol. Chem. 274, 33002-33010.

20. Bacolla, A., Pradhan, S., Roberts, R.J., and Wells, R.D. (1999). Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveals allosteric activation by methylated DNA. J. Biol. Chem. 274, 33011-33019.

21. Parniewski, P., Bacolla, A., Javorski, A., and Wells, R.D. (1999). Nucleotide excision repair affects the stability of long transcribed (CTG•CAG) tracts in an orientation-dependent manner in Escherichia coli. Nucleic Acids Res. 27, 616-623.

22. Wells, R.D., Parniewski, P., Pluciennik, A., Bacolla, A., Gellibolian, R., and Jaworski, A., (1998). Small slipped register genetic instabilities in Escherichia coli in triplet repeat sequences associated with hereditary neurological diseases. J. Biol. Chem. 273, 19532-19541.

23. Gellibolian, R., and Bacolla, A. (1998). Biophysical and structural studies on triplet repeat sequences: duplex triplex repeat structures. In: Genetic Instabilities and Hereditary Neurological Diseases (Robert. D. Wells and Stephen T. Warren, Eds.), Academic Press, San Diego, pp. 561-583.

24. Bacolla, A., Bowater, R.P., and Wells, R.D. (1998). Systems for the study of genetic instabilities: Escherichia coli. In: Genetic Instabilities and Hereditary Neurological Diseases (Robert. D. Wells and Stephen T. Warren, Eds.), Academic Press, San Diego, pp. 467-484.

25. Wells, R.D., Bacolla, A., and Bowater, R.P. (1998). Instabilities of triplet repeats: factors and mechanisms. Results Probl. Cell Differ. 21, 133-165.

26. Bacolla, A., Gellibolian, R., Shimizu, M., Amirhaeri, S., Kang, S., Ohshima, K., Larson, J.E., Harvey, S.C., Stollar, B.D., and Wells, R.D. (1997). Flexible DNA: genetically unstable CTG•CAG and CGG•CCG from human hereditary neuromuscular disease genes. J. Biol. Chem. 272, 16783-16792.

27. Gellibolian, R., Bacolla, A., and Wells, R.D. (1997). Triplet repeat instability and DNA topology: an expansion model based on statistical mechanics. J. Biol. Chem. 272, 16793-16797.

28. Bacolla, A., Ulrich, M.J., Larson, J.E., Ley, T.J., and Wells, R.D. (1995). An intramolecular triplex in the human γ- globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin. J. Biol. Chem. 270, 24556-24563.

29. Bacolla, A., Shih, C.-K., Rose, J.M., Piras, G., Warren, T.C., Grygon, C.A., Ingraham, R.H., Cousins, R.C., Greenwood, D.J., Richman, D., Cheng, Y.-C., and Griffin, J.A. (1993). Amino acid substitutions in HIV-1 reverse transcriptase with corresponding residues from HIV-2: effect on kinetic constants and inhibition by non-nucleoside analogs. J. Biol. Chem. 268, 16571-16577.

30. Shih, C.-K., Rose, J.M., Hansen, G.L., Wu, J.C., Bacolla, A., and Griffin, J.A. (1991). Chimeric HIV-1/HIV-2 reverse transcriptase display reversed sensitivity to non-nucleoside analog inhibitors. Proc. Natl. Acad. Sci. U.S.A. 88, 9878-9882.

31. Bacolla, A., and Wu, F.Y.-H. (1991). Mung bean nuclease cleavage pattern at a polypurine•polypyrimidine sequence upstream from the mouse metallothionein-I gene. Nucleic Acids Res. 19, 1639-1647.

32. Christophe, D., Gérard, C., Juvenal, G., Bacolla, A., Teugels, E., Ledent, C., Christophe-Hobertus, C., Dumont, J.E., and Vassart, G. (1989). Identification of a cAMP-responsive region in thyroglobulin gene promoter. Mol. Cell. Endocrinol. 64, 5-18.

33. Christophe, D., Cabrer, B., Bacolla, A., Targovnik, H., Pohl, V., and Vassart, G. (1985). An unusually long poly(purine)•poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene. Nucleic Acids Res. 13, 5127-5144.

34. Vassart, G., Bacolla, A., Brocas, H., Christophe, D., de Martynoff, G., Gérard, C., Hansen, C., Juvenal, G., Merken, L., Parma, J., Roger, P., and Van Heuverswyn, B. (1985). The thyroglobulin gene: structure and control of expression. In Thyroid Cancer, C. Jaffiol and G. Milhaud, Eds., Elsevier Science Publishers B.V. (Biomedical Division), pp. 47-51.

35. Vassart, G., Bacolla, A., Brocas, H., Christophe, D., de Martynoff, G., Leriche, A., Merken, L., Parma, J., Pohl, V., Targovnik, H., and Van Heuverswyn, B. (1985). Review. Structure, expression and regulation of the thyroglobulin gene. Mol. Cell. Endocrinol. 40, 89-97.

36. Costa, A., Cottino, F., Ariano, M., Bacolla, A., Bellero, V., Chiecchio, A., and Lorenzini, P. (1982). Comparison between inhaled and ingested iodine metabolism. J. Nucl. Med. All. Sci. 26, 89-96. 36. Giraudi, G., and Bacolla, A. (1982). The kinetics and mechanism of the interaction between thyroxine and serum binding proteins. In Advances on Thyroid Hormones, A.L. Carpi, Ed., ETS Pisa, pp. 299-318.

37. Gallone, G., Bacolla, A., Testori, O., and De Filippis, V. (1984). Le proteine vettrici ed anticorpali come fattore di complicazione nella determinazione degli ormoni tiroidei. In Quaderni di Ligand Quarterly. Aspetti Critici delle Metodiche RIA, G. Cenderelli, G. Giraudi and R. Malvano, Eds., pp. 449-465.

38. Bacolla, A., Giraudi, G., Lorenzini, P., Varacca, G., and Costa, A. (1983). Observations on iodine exchange in thermal therapy with salsobromoiodic water. Pan. Med. 25, 241-247. 39. Bacolla, A., Costa, A., Giraudi, G., Lorenzini, P., and Varacca, G. (1983). Osservazioni sul ricambio dello iodio nella terapia termale con acque salsobromoiodiche. Min. Med. 74, 2625-2631.

40. Costa, A., Pilotti, G., and Bacolla, A. (1983). La diagnosi differenziale nello screening dell'ipotiroidismo neonatale. In Lo Screening dell'Ipotiroidismo Congenito in Italia, S. Varrone, A. Mariano, A. Tenore and V. Macchia, Eds., Biodata, pp. 127-134.

41. Costa, A., Cottino, F., Bacolla, A., Giraudi, G., and Lorenzini, P. (1983). The quantitative evaluation and the metabolism of the inhaled iodine. J. Nucl. Med. All. Sci. 27, 92.

42. De Filippis, V., and Bacolla, A. (1983). Un modello organizzativo per lo screening neonatale dell'ipotiroidismo congenito. In Lo Screening dell'Ipotiroidismo in Italia, S. Varrone, A. Mariano, A. Tenore and V. Macchia, Eds., Biodata, pp. 17-19.

43. De Filippis, V., Bacolla, A., Godano, A., Valmaggia, P., Panizzo, M., Mongardi, M., and Costa, A. (1982). Lo screening dell'ipotiroidismo congenito in Piemonte. In Lo Screening dell'Ipotiroidismo in Italia: il Punto della Situazione, Giovannelli G., Ed., Parma, 1982, pp. 9-13.

44. De Filippis, V., Fabris, C., Bacolla, A., Bertino, E., Migliardi, M., Trapani, G., Chillemi, C., Mombró, M., Mongardi, L., Montrucchio, F., Garzena, E., and Costa, A. (1981). Screening dell'ipotiroidismo congenito. Risultati su una casistica di 20.000 neonati. Min. Ped. 33, 289-298.

45. Fabris, C., Bacolla, A., Bertino, E., Merlin, P., Montrucchio, F., and De Filippis, V. (1981). Deficit congenito di globulina legante la tiroxina (TBG). Studio di tre famiglie. Min. Ped. 33, 205-212.

46. Siclari, C., Fenzi, G.F., Doveri, F., Bacolla, A., Mariotti, S., Marcocci, C., Pacini, F., Vitti, P., Pinchera, A., and Baschieri, L. (1981). L'endemia gozzigena in provincia di Pisa. Indagine su fattori ambientali ed alimentari. Rivista Italiana d'Igiene XLI, 112-119.

47. Bertino, E., Bacolla, A., Trapani, G., Merlin, P., and Fabris, C. (1981). Studio genetico del deficit congenito di TBG in gruppi di familiari di neonati individuati mediante lo screening dell'ipotiroidismo congenito. Giornale dell'Accademia di Medicina di Torino CXLIV, 125-130.

48. Bacolla, A. (1981). Aspetti tecnici dello screening dell'ipotiroidismo congenito. Giornale dell'Accademia di Medicina di Torino CXLIV, 16-27.

49. Bacolla, A., Castelli, G., and Avanzini, P. (1979). Diagnosi dell'ipotiroidismo neonatale mediante dosaggio della tiroxina su sangue essiccato. Osservazioni di tecnica. Min. Nip. 29, 185-192.

50. Costa, A., Lorenzini, P., Brambati-Testori, O., Cottino, F., and Bacolla, A. (1977). Aspetti ormonali, metabolici, terapeutici di elevati apporti di iodio in un ambiente termale (Salsomaggiore). Min. Ecol. 17, 107-117.

Vasquez Lab © 2009