Dr. R. Adron Harris
Some Recent Publications from the Harris Lab
Blednov, Y.A., Walker, D., Martinez, M. and Harris, R.A. Reduced alcohol consumption and palatability in mice lacking preprodynorphin. Alcohol, 40:73-86, 2006. pdf
Boehm II, S.I., Ponomarev, I., Blednov, Y.A., and Harris, R.A. From gene to behavior and back again: New perspectives on GABA-A receptor subunit selectivity of alcohol actions. In Advances in Pharmacology Volume 54, (Enna, S.J. ed.), Elsevier, pp. 171-203, 2006.
Sonner, J.M., Werner, D.F., Elsen, F.P., Xing, Y., Liao, M., Harris, R.A., Harrison, N.L., Fanselow, M.S., Eger II, E.I. and Homanics, G.E. Effect of isoflurane and other potent inhaled anesthetics on MAC, learning, and the righting reflex in mice engineered to express a1 GABAA receptors unresponsive to isoflurane. Anesthesiology, 106:107-113, 2006. pdf
Werner, D.F., Blednov, Y.A., Ariwodola, O.J., Silberman, Y., Logan, E., Berry, R.B., Borghese, C.M., Matthews, D.B., Weiner, J.L., Harrison, N.L., Harris, R.A. and Homanics, G.E. Knock-in mice with ethanol-insensitive alpha1-containing GABAA receptors display selective alterations in behavioral responses to ethanol. J. Pharmacol. Expt. Ther., 319:219-227, 2006. pdf
Crabbe, J.C., Phillips, T.J., Harris, R.A., Arends, M.A. and Koob, G.F. Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology, 11:195-269, 2006. pdf
Lobo, I.A., Trudell, J.R. and Harris, R.A. Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharm., 50:174-181, 2006. pdf
Liu, J., Lewohl, J.M., Harris, R. A., Iyer, V., Dodd, P.R., Randall, P.K. and Mayfield, R.D. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharm. 31:1574-1582, 2006. pdf
Maiya, R., Linse, K.D., Ponomarev, I, Harris R.A., and Mayfield, R.D. Defining the dopamine transporter proteome by convergent biochemical and in silico analyses. April 27 Epub, Genes, Brain and Behavior, 2006. pdf
Boehm II, S.I., Homanics, G.E., Blednov, Y.A. and Harris, R.A. delta-Subunit containing GABA-A receptor knockout mice are less sensitive to the actions of THIP. European J. Pharm., 541:158-162, 2006. pdf on request
Borghese, C.M., Storustovu, S.I., Ebert, B., Herd, M.B., Belellie, D., Lambert, J.J., Marshall, G., Wafford, K.A. and Harris, R.A. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. J. Pharmacol. Expt. Ther., 316:1360-1368, 2006. pdf
Mulligan, M.K., Ponomarev, I., Hitzemann, R.J., Belknap, J.K., Tabakoff, B., Harris, R.A., Crabbe, J.C., Blednov, Y.A., Grahame, N.J., Phillips, T.J., Finn, D.A., Hoffman, P.L., Iyer, V.R., Koob, G.F. and Bergeson, S.E. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PNAS, 103:6368-73, 2006. pdf
Ogata, J., Shiraishi, M., Namba, T., Smothers, C.T., Woodward, J.J., Harris, R.A. Effects of anesthetics on mutant N-Methyl-D-spartate receptors expressed in Xenopus Oocytes. J. Pharmacol. Expt. Ther., 318:434-443, 2006. pdf
Ponomarev, I., Maiya, R., Harnett, M.T., Schafer, G.L., Ryabinin, A.E., Blednov, Y.A., Morikawa, H., Boehm II S.L., Homanics, G.E., Berman, A., Lodowski, K.H., Bergeson, S.E. and Harris, R.A. Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. J Neurosci., 26:5673-83, 2006. pdf
Krystal, J.H., Staley, J., Mason, G., Petrakis, I.L., Kaufman, J., Harris, R.A., Gelernter, J.E., Lappalainen, J. GABA Type A receptors and alcoholism: Intoxication, dependence, vulnerability and treatment. Arch Gen Psychiatry, 63:957-968, 2005. pdf
Dani, J.A. and Harris, R.A. Nicotine addiction and comorbidity with alcohol abuse and mental illness.
Nature Neurosci. 8:1465-1470, 2005. pdf
Blednov, Y.A., Bergeson, S.E., Walker, D., Ferreira, V.M., Kuziel, W.A. and Harris, R.A. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behavioral Brain Res. 165:110-125, 2005. pdf
Jung, S., Akabas, M.H. and Harris, R.A. Functional and structural analysis of the GABA-A receptor alpha-1
subunit during channel gating and alcohol modulation. J. Biol. Chem., 280: 308-316, 2005. pdf
Boehm II, S.L., Peden, L., Harris, R.A. and Blednov, Y.A. Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: Dependence on beta2/beta3 GABA-A receptor subunits. J. Pharmacol. Expt. Ther., 309: 1154-1159, 2004. pdf
Harris, R.A. and Mihic, S.J. Alcohol and inhibitory receptors: Unexpected specificity from a nonspecific drug. PNAS, 10: 1073, 2004. pdf
Liu, J., Lewohl, J.M., Dodd, P.R., Harris, R.A. and Mayfield, R.D. Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J. Neurochem., 90:1050-58, 2004. pdf
Lobo, I.A., Trudell, J.R. and Harris, R.A. Crosslinking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. J. Neurochem., 90: 962-69, 2004. pdf
Lobo, I.A., Mascia, M.P., Trudel, J.R. and Harris, R.A. Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J. Biol. Chem., 279:33919-27, 2004. pdf
Shiraishi, M., and Harris, R.A. Effects of alcohols and anesthetics on recombinant voltage-gated Na+ channels. J. Pharmacol. Expt. Ther., 309:987-994, 2004. pdf
Blednov YA, Stoffel M, Alva H, and Harris RA. A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci USA 100: 277-282, 2003. pdf
Mascia MP, Trudell JR and Harris RA. Specific binding sites for alcohols and anesthetics on ligand gated ion channels. PNAS, 97: 9305-9310, 2000. pdf
Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA and Harris RA. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nature Neuroscience, 2: 1084-1090, 1999. pdf