Abstract: A decade ago little was known about the neurobiological architecture for

decision-making. Today the broad outlines of that system have been

identified. Frontal and basal-ganglia circuits involved in valuation and

learning have been described that generate the subjective values that

guide choice. These valuations then pass to frontal and parietal circuits

for actual decision-making. In this presentation I will review the basic

structure of this two part mechanism for decision-making. I will then

present a recent example study of the human valuation circuit that

participates in inter-temporal choice followed by a related study of the

choice mechanism in non-human primates.