The University of Texas Researchers Win Grant to Develop Drug to Treat Addiction

May 24, 2012

AuSTIN, Texas — Researchers at The University of Texas at Austin are teaming up to develop medication to treat alcoholism and drug addiction that could target individual genes or brain signaling systems.

They have received a $3.3 million, five-year grant from the National Institute on Alcohol Abuse and Alcoholism, a part of the National Institutes of Health (NIH), for the project.

"The goal is to take some very new directions for developing medications for alcohol dependence and drug addiction," said R. Adron Harris, the project's principal investigator and director of the university's Waggoner Center for Alcohol and Addiction Research. "Addiction is one of the most prevalent health problems in the country, and there are very few medications for treating it."

The medication could be a pill, Harris said, although it's too early in the research to be definite about what form it might take.

He said the eight researchers involved have extensive backgrounds in alcohol research and bring complementary research skills and expertise in instrumentation techniques to the project. All are affiliated with the Waggoner Center and several are on the faculties of the College of Pharmacy and the College of Natural Sciences.

"It brings together molecular approaches, genetic approaches, behavioral and electrophysiology," Harris said. "It's all directed at the same question but all being done in different labs by different people."

The researchers want to identify targets where alcohol and drugs affect the brain and then identify medications that would block alcohol and drugs from hitting those targets.

There are two tracks to the research. One will examine genes that have been identified with alcohol dependence and addiction, and the other involves peptides that affect brain-signaling systems.

"Our approach is to change gene function with an approach that is different from gene therapy," Harris said of the first track. "We're not changing the gene. We're changing which genes are turned on and turned off using 'master regulators' called microRNA."

In the second track, researchers will investigate peptides, which are involved in signaling systems in the brain.

"The peptides act on the signaling systems in the brain to counteract or correct the effects of alcohol abuse," Harris said.

Researcher John Mihic has developed a way to screen millions of peptides to find the few that would be effective.

Harris said the most promising drugs to emerge from the research would go to collaborators at other institutions for clinical testing.

"At present, we don't have a medical school at UT Austin, so we are limited in what we can do here," he said. "But we have collaborators at other sites that will be interested in testing medications."

Last month, The University of Texas Board of Regents committed up to $30 million a year to establish a medical school at The University of Texas at Austin.

The researchers are working under a project program grant from the NIH.

"This is a mechanism that simultaneously funds multiple projects," Harris said. "It will enable us to work together better and to do more things than we could on our own."

The other researchers in the project are Igor Ponomarev, research assistant professor, R. Dayne Mayfield, research scientist, and Yuri Blednov, research scientist, in the Waggoner Center; Rueben Gonzales and Richard Morrisett, professors in the College of Pharmacy; and Hitoshi Morikawa, associate professor, Section of Neurobiology in the College of Natural Sciences.

For more information, contact: Tim Green, Office of the Vice President for Research.

3 Comments to "The University of Texas Researchers Win Grant to Develop Drug to Treat Addiction"

1.  myhornsarelong said on May 30, 2012

haha this reads like an onion article. Lets just trade off one drug for another. How bout trying to prevent addiction .. rather than simply treating it? oh right because there is no profit in that..

2.  Mike Weatherl said on June 2, 2012

yup; agreed. Like methadone or suboxone. Suboxone saves lives, but docs will basically keep you on it indefinitely. EVERY single person I know who's used it to get off painkillers (and succeeded) has eventually had to bite the bullet, ween themselves off (on their own initiative, usually without direction from their doctor), and be moderately dopesick for a few weeks, with mild effects lasting for months. But again, it DOES work, if you have the money or good insurance. Its definitely trading one drug for another, but it absolutely changes the nature of the ailment from an addiction (which implies obsession) to a physical dependance (no more cravings, just guaranteed chemical depression - no dopamine, without the medication). Free-will ceases to exist for a while. I won't get too specific, but I've experienced it personally and also have been around dozens of other people going through the same thing. That being said, the only reason that doctors and patients choose opiate-maintainance is because there's really no better option (other than lockdown in a jail-cell or whatever). Its truly tragic. Even worse, addiction in the US is essentially criminalized. Suboxone (buprenorphine) is the only solution that actually reduces & eliminates cravings. Opiates in general are incredibly difficult to get off of; withdrawal symptoms last longer and are more intense than any other substance-abuse scenario. And those are not my words. I owe everything to my therapist - there aren't very many great ones out there. I hope that someday a better alternative can be developed, by any means necessary (within reason). I know more people who've died from OD than people who've recoved from full-blown opiate addiction. As for alcohol and other drugs, I wouldn't know. Anyway.... thats my 200000 cents.

3.  Helen Alexander said on June 4, 2012

I disagree completely with "myhornsarelong." As a lifelong School Psychologist, I saw miracles accomplished when school children received the appropriate medications to control brain functioning when it was (call it) "mis-wired." It may have helped Big Pharma, but it saved the sanities of hundreds of parents, and the talents and the lives of hundreds of teens. PLEASE continue the search for a way to block the genetic propensity in the brain for addictions!