Center for Molecular & Cellular Toxicology

CMCT Faculty

The distinguished group of faculty mentors participating in the CMCT have successful independent research programs with a shared focus on deciphering the underlying cellular, biochemical, and molecular responses to environmental exposures. This common vision of the training faculty and the contemporary state-of-the-art biochemical, molecular, and cellular approaches that they employ in their experimental approaches coalesce to make this a distinctive and cohesive training program.

The research interests of the training program member faculty fall into four broadly defined, but interactive, research areas : molecular and cellular responses that mediate toxicity; mechanisms of environmental carcinogenesis and its prevention; DNA repair and epigenetics; and critical developmental periods and endocrine disruption.

Binding each of these research focus areas is the unifying theme: to define host responses to environmental toxicants and to dissect the influence of genetic background, developmental age and diet on these responses. Each one of these distinct research areas consists of teams of researchers who conduct innovative complementary interdisciplinary research. There are significant collaborative interactions both within as well as between the four focus areas of this training program.

It should be noted that some training faculty may fit into more than one of these areas which also facilitates collaborative interactions and transdisciplinary research and training.

 

MOLECULAR AND CELLULAR RESPONSES THAT MEDIATE TOXICITY

Shawn B. Bratton, Ph.D., Associate Professor, UT MD Anderson Cancer Center, Science Park-Research Division; Basic mechanisms of apoptosis.

http://www.mdanderson.org/education-and-research/departments-programs-and-labs/labs/bratton-lab/index.html

Richard L. Corsi, Ph.D., Professor, Department of Civil, Architectural and Environmental Engineering;Analysis and control of fugitive contaminant emissions from industrial wastewater and process streams; cross-media contaminant transport; atmospheric transport modeling; indoor air quality.

http://www.ce.utexas.edu/faculty-directory/profiles/richard-corsi.html

Walter Fast, Ph.D., Associate Professor of Medicinal Chemistry; Enzymology of Arginine Modification and Bacterial Communication. Enzyme Mechanisms, Inhibitor Design, Protein Engineering.

http://www.utexas.edu/pharmacy/divisions/medicinalchem/faculty/fast.html

David G. Johnson, Ph.D., Professor, UT MD Anderson Cancer Center, Science Park-Research Division; E2F transcription factors, cell cycle, tumor suppressor genes, oncogenes.

http://sciencepark.mdanderson.org/Documents/DJohnson/johnson.html

Sean M. Kerwin, Ph.D., Associate Professor of Medicinal Chemistry; Covalent modification of DNA by small molecules including carcinogens, natural products, and drugs; G-quadruplex DNA structures as sites for DNA damage and drug interaction; synthesis of natural products and analogs to probe molecular mechanisms related to cancer prevention and treatment.

http://www.utexas.edu/pharmacy/divisions/medicinalchem/faculty/kerwin.html

Som Mukhopadhyay, Ph.D., The regulation of manganese (Mn) homeostasis in mammalian cells and in the pathobiology of Mn-induced neurotoxicity. Specifically, evaluating the export of Mn via the Golgi followed by secretion as the primary route of Mn efflux and detoxification in mammalian cells.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/mukhopadhyay.html

John H. Richburg, Ph.D., Professor of Pharmacology and Toxicology; Mechanisms Regulating Apoptosis/Male Reproductive Toxicology. Peripubertal sensitivity to testicular toxicants.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/richburg.html

Casey W. Wright, Ph.D., Assistant Professor of Pharmacology and Toxicology; Mechanisms of NF-kB signaling in lymphoid malignancies including how environmental sensors (AHR, ARNT) module NF-kB activity. http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/wright.html


MECHANISMS OF ENVIRONMENTAL CARCINOGENESIS AND ITS PREVENTION

Kevin Dalby, Ph.D., Professor of Medicinal Chemistry; Potential for cancer treatment through the targeting of protein kinases by utilizing novel efforts in chemical biology.

http://www.utexas.edu/pharmacy/divisions/medicinalchem/faculty/dalby.html

John DiGiovanni, Ph.D., Professor of Pharmacology & Toxicology and Coulter R. Sublett Chair, Identification of critical targets for both the initiation and promotion stages of carcinogenesis.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/digiovanni.html

Susan M. Fischer, Ph.D., Professor of Molecular Carcinogenesis, The University of Texas, M. D. Anderson Cancer Center-Science Park, Multistage chemical carcinogenesis, elucidate the function and regulation of the enzymes involved in arachidonic acid metabolism in skin, and develop dietary and other approaches to skin cancer prevention.

http://faculty.mdanderson.org/Susan_Fischer/

Stephen D. Hursting, Ph.D., Professor of Nutrition; Diet-gene interactions relevant to cancer prevention, particularly the molecular and hormonal mechanisms underlying energy balance-cancer associations.http://he.utexas.edu/directory/hursting-stephen

Kimberly Kline, Ph.D., Professor of Nutritional Sciences; Nutrition and cancer biology. http://he.utexas.edu/directory/kline-kimberly

Edward Mills, Ph.D., Associate Professor of Pharmacology and Toxicology; Understanding how mitochondria talk to other cellular components and how mitochondria participate in the pharmacologic and toxic actions of chemicals and in disease processes.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/mills.html

Bob Sanders, Ph.D., Professor of Molecular Genetics and Microbiology; Cancer biology and immunology. http://he.utexas.edu/directory/sanders-bob-g

Dean Tang, M.D., Ph.D., Professor of Carcinogenesis; Cancer stem cells, prostate cancer, and apoptosis.

http://sciencepark.mdanderson.org/labs/tang


DNA REPAIR AND EPIGENETICS

Mark T. Bedford, Ph.D., Professor, UT MD Anderson Cancer Center, Science Park-Research Division; Arginine methylation, WW domains, Protein-protein interactions, Gene targeting.

http://sciencepark.mdanderson.org/faculty/bedford_m/index.html

Sean M. Kerwin, Ph.D., Associate Professor of Medicinal Chemistry; Covalent modification of DNA by small molecules including carcinogens, natural products, and drugs; G-quadruplex DNA structures as sites for DNA damage and drug interaction; synthesis of natural products and analogs to probe molecular mechanisms related to cancer prevention and treatment.

http://www.utexas.edu/pharmacy/divisions/medicinalchem/faculty/kerwin.html

Kevin McBride, Ph.D., Assistant Professor, UT MD Anderson Cancer Center, Science Park-Research Division; DNA hypermutation and recombination, error prone DNA repair, single cell mutation analysis.

http://faculty.mdanderson.org/Kevin_McBride/Default.asp?SNID=0

Karen M. Vasquez, Ph.D., Professor of Pharmacology & Toxicology and Coulter R. Sublett Fellow; Elucidate the molecular mechanisms of DNA damage recognition by DNA repair and recombination pathways, Develop triplex technology to modify mammalian gene structure and function, Study the role of DNA structure in genomic instability and mutagenesis.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/vasquez.html


CRITICAL DEVELOPMENTAL PERIODS AND ENDOCRINE DISRUPTION

C. Marcelo Aldaz, M.D., Professor, UT MD Anderson Cancer Center, Science Park-Research Division; Breast cancer, hormonal carcinogenesis; Mammary tumor models.

http://sciencepark.mdanderson.org/Documents/CAldaz/Aldaz.html

David Crews, Ph.D., Professor of Integrative Biology; How biological and chemical factors early in development influence the development of behavior and its neural substrates of various vertebrate species, particularly the development and function of sex and individual differences. http://www.biosci.utexas.edu/directory/details.aspx?id=1506

Richard H. Finnell, Ph.D., Professor, Department of Nutritional Sciences and Director of Genomic Research at the Dell Children’s Medical Center; Study of the interaction between specific genes and nutritional factors as they influence normal embryonic development; revealing the relationships between the folic acid metabolic pathway and risk genes associated with birth defects.

http://finnelllab.com

Andrea C. Gore, Ph.D., Professor of Pharmacology and Toxicology; Neural mechanisms of reproductive development and puberty, Effects of environmental and hormonal factors that perturb reproductive function, Neural mechanisms for reproductive senescence.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/gore.html

Peter Thomas, Ph.D., Professor of Zoology and Marine Science; Reproductive endocrine toxicology, mechanisms of endocrine disruption by xenobiotic chemicals, environmental toxicology of aquatic organisms.

http://www.utmsi.utexas.edu/staff/thomas.htm

Carla Van Den Berg, PharmD., Associate Professor of Pharmacology and Toxicology; Role of growth factor-mediated treatment resistance in breast cancer.

http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/vandenberg.html

Ying Xu, Ph.D., Assistant Professor of Civil, Architectural, & Environmental Engineering; Fate and transport of semi-volatile endocrine disrupting compounds (e.g. phthalates, PBDEs, and organophosphates), human exposure to endocrine disrupting compounds, environmental modeling, indoor environment quality and healthy building.

http://www.caee.utexas.edu/faculty/directory/xu


Last Reviewed: July 10, 2014

John H. Richburg,
Ph.D., Director
CMCT
College of Pharmacy
The University of Texas
at Austin
2409 University Ave. Stop: A1900
Austin, TX
78712-01200
USA

For information, contact Anita Conley Mote:
cmct
@austin.utexas.edu

Phone:
1-512-471-2061

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