Cytochrome P-450 Multiplicity

• Superfamily: Current estimates >1000 genes.

• Some of these ìpseudogenesî.

• Humans: Current estimates ~ 50 genes (10 pseudogenes). ~35-40 distinct P-450ís in 16 ìfamiliesî.

• Initially simple P-450ís cholesterol & FAís form membranes) Millions of years; evolved Endogenous -> Endogenous + Exogenous

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