Factor Affecting Drug Metabolism

• Heredity/Genetics

  • Genetic Polymorphism = demonstrably different forms or levels of enzyme(s) in distinct population
  • Defined by >1% incidence in population.
  • e.g. lower or non-functional P450ís-> ìpoor metabolizersî -> toxicity.
  • Interindividual or interracial differences.
  • Pharmacogenetics

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