Factor Affecting Drug Metabolism

• Heredity/Genetics: Example CYP2D6

  • Metabolizes many drugs.
  • Deficiency: 5-10% Caucasians 2% Asians 1% Arabic
  • Consequences: Poor metabolism

    • Amitryptyline
    • Dextromethorphan
    • Codeine -> morphine (analgesia)

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