Factor Affecting Drug Metabolism
Heredity/Genetics: Example CYP2C21
- C21 hydroxylase ----------> Cortisol
- Deficiency
- Decrease corisol => ACTH increases
- Adrenal hyperplasia => Androgenic steroids
- Consequences
- Virulization of females; baldness.
- Precocious sexual development in males.
- Salt/water imbalance (aldosterone)
- Premature epiphyseal closure (growth stops).