Fast, Walter L., Ph.D.
Associate Professor
BME 6.202D
512-232-4000
waltfast@mail.utexas.edu

Search Medline database at PubMed for articles by W Fast

27. Momb, J.; Wang, C.; Liu, D.; Thomas, P.W.; Pestko, G.A.; Guo, H.*; Ringe, D.*, Fast, W.* Mechanism of the quorum-queching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active-site mutations. Biochemisty, 2008, 47, 7715-7725.

26. Liu, D.; Momb, J.; Thomas, P.W.; Moulin, A.; Petsko, G.A.; Fast, W.*; Ringe, D.* Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry, 2008, 47, 7706-7714.

25. Linsky, T.; Mondragon, A.; Stone, E.; Robertus, J.D.*; Fast, W.* Promiscuous partitioning of a covalent intermediate common in the pentein superfamily. Chemistry and Biology 2008, 15, 467-75.

24. Hong, L.; Fast, W. Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide: Analysis, quantification and implications for hyperhomocysteinemia. J. Biol. Chem., 2007, 282, 34684-34692.

23. Liu, D.; Thomas, P.W.; Momb, J.; Hoang, Q.Q.; Petsko, D.; Ringe, D.*; Fast, W.* Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens. Biochemistry, 2007, 46, 11789-11799.

22. Momb, J.; Thomas, P.W.; Breece, R.M.; Tierney, D.L.*; Fast, W.* The Quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis exhibits a leaving group thio effect. Biochemistry, 2006, 45, 13385-13393.

21.Thompson, P.R.* and Fast, W.* (Review) Histone citrullination by protein arginine deiminase: Is arginine methylation a green light or a roadblock? ACS Chemical Biology, 2006, 1, 433-441.

20. Stone, E.M.; Costello, A.L.; Tierney, D.L.*; Fast, W.* Substrate-Assisted Cysteine Deprotonation in the Mechanism of Dimethylargininase (DDAH) from Pseudomonas aeruginosa. Biochemistry, 2006, 45, 5618-5630.

19. Stone, E.M.; Schaller, T.H.; Bianchi, H.; Person, M.D.; Fast, W. Inactivation of Two Diverse Enzymes in the Amidinotransferase Superfamily: Dimethylargininase and Peptidylarginine Deiminase. Biochemistry, 2005, 44, 13744 - 13752.

18. Liu, D.; Lepore, B.; Petsko, G.A.; Thomas, P.W.; Stone, E.M.; Fast, W.*; Ringe, D.* (*Co-corresponding authors) Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. Proc. Natl. Acad. Sci. USA, 2005, 102, 11882-11887.

17. Fast, W. (Invited book review): P.G. Wang, T.B. Cai, and N. Taniguchi Eds. “Nitric Oxide Donors; for pharmaceutical and biological applications”, Weinheim, Germany: Wiley-VCH, 2005. J. Med. Chem., 2005, 48, 5056.

16. Stone, E.M.; Fast, W. A Continuous Spectrophotometric Assay for Dimethylarginine Dimethylaminohydrolase, Analytical Biochemistry, 2005, 343, 335-337.

15. Thomas, P.W.; Stone, E.M.; Costello, A.L.; Tierney, D.L.; Fast, W. The Quorum-quenching Lactonase from Bacillus thuringiensis is a Metalloprotein, Biochemistry 2005, 44, 7559-7569.

14. Stone, E.M.; Person, M.D.; Costello, N.J.; Fast, W.   Characterization of a Transient Covalent Adduct Formed During Dimethylarginine Dimethylaminohydrolase Catalysis, Biochemistry 2005, 44, 7069-7078.

13. Fast, W. (Invited Preview) Molecular Radio Jamming: Autoinducer Analogs.   Chem. Biol . 2003, 10, 1-2.

12. Huntley, J.J.; Fast, W. ; Benkovic, S.J.; Wright, P.E.; Dyson, H.J. Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase. Protein Sci . 2003, 12, 1368-1375.

11. Lutz, S.; Fast. W. ; Benkovic, S.J. A Universal, Vector-based System for Nucleic Acid Reading-frame Selection. Protein Engineering 2002, 15 , 1025-1030.

10. Fast, W. ; Wang, Z.; Benkovic, S.J. Familial Mutations and Zinc Stoichiometry Determine the Rate-limiting Step in Nitrocefin Hydrolysis by Metallo- beta -lactamase from Bacteroides fragilis . Biochemistry 2001, 40 , 1640-1650.

9. Wang, Z.; Fast, W. ; Valentine, A.M.; Benkovic, S.J. Metallo- b -lactamase: Structure and Function. Curr. Opin. Chem. Biol . 1999, 3, 614-622.

8. Wang, Z.; Fast, W. ; Benkovic, S.J. On the Mechanism of the Bacteroides fragilis Metallo- beta -Lactamase. Biochemistry 1999, 38 , 10013-10023.

7. Huang, H.; Lee, Y.; Zhang, H.Q.; Fast, W. ; Riley, B.; Silverman R.B. Selective Inhibition of Nitric Oxide Synthases. In Medicinal chemistry into the Millennium ; M.M. Campbell, I.S. Blagbrough, Eds.; Royal Society of Chemistry: Edinburgh, Scotland, 2001; Vol. 15, 303-328.

6. Fast, W. ; Nikolic, D.; VanBreemen, R.B.; Silverman, R.B. Mechanistic Studies of the Inactivation of Inducible Nitric Oxide Synthase by N 5 -(1-Iminoethyl)- L - ornithine ( L -NIO). J. Am. Chem. Soc. 1999, 121 , 903-916.          

5. Wang, Z.; Fast, W. ; Benkovic, S.J. Direct Observation of an Enzyme-Bound Intermediate in the Catalytic Cycle of the Metallo- beta -lactamase from Bacteroides fragilis . J. Am. Chem. Soc. 1998 , 120, 10788-10789.

4. Fast, W. ; Levsky, M.; Marletta, M.A.; Silverman, R. B. N w -Propargyl- L -arginine and N w -Hydroxy- N w -propargyl- L -arginine are Inhibitors, but not Inactivators of Neuronal and Macrophage Nitric Oxide Synthases. Bioorg. Med. Chem. 1997 , 5,1601-1608.

3. Fast, W. ; Huff, M. E.; Silverman, R. B. Time-Dependent Inhibition of Neuronal Nitric Oxide Synthase by N-Propargylguanidine Bioorg. Med. Chem. Lett. 1997, 7 , 1449-1454.

2. Zhang, H. Q.; Fast, W. ; Marletta, M. A.; Martasek, P.; Silverman, R. B. Potent and Selective Inhibition of Neuronal Nitric Oxide Synthase by N w -Propyl- L - arginine. J. Med. Chem. 1997, 40 , 3869-3870.

1. Hedstrom, L.; Lin, T.Y.; Fast, W. Hydrophobic Interactions Control Zymogen Activation in the Trypsin Family of Serine Proteases. Biochemistry 1996, 35, 4515- 4523.

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