Medicinal Chemistry



Kerwin, Sean M., Ph.D.
Professor of Med. Chem.
G.D. Searle & Co.
Endowed Fellowship in Pharmacy
BME 6.202C

Selected Publications

  • Plyler, J.; Jasheway, K.; Karr, J.; Brennan, J. S.; Kerwin, S. M.; David, W. M. “Real-time Investigation of SV40 Large T-antigen Helicase Activity Using Surface Plasmon Resonance” Cell Biochem. Biophys. 2009, 53, 43-52.
  • Galal, S. A.; Hagab, K. H.; Kassab, A. S.; Rodriguez, M.; Kerwin, S. M.; El-Khamry, A-M. A.; El Diwani, H. I. “New Transition Metal Ion Complexes with Benzimidazole-5-Carboxylic Acid Hydrazides with Antitumor Activity” Eur. J. Med. Chem., 2009, 44, 1500-1508.
  • Marriner, W. A.; Kerwin, S. M. “An Improved Synthesis of N’-Nitroso-Nornicotine-5’-Acetate” J. Org. Chem. 200974,  2891-2892.
  • Laroche, C.; Li, J.; Kerwin, S. M. “Lithiation and Functionalization of N-Alkynylimidazoles at the 2-Position” Tetrahedron Lett. 2009, 50, 5194-5197.
  • Wang, X.; Pang, J.; Maffucci, J. A.; Newman, R. A.; Kerwin, S. M.; Bowman, P. D.; Stavchansky, S.  “Pharmacokinetics of Caffeic Acid Phenethyl Ester and its Catechol-Ring Fluorinated Derivative Following Intravenous Administration to Rats”  Biopharm. Drug Disp. 2009, 30, 221-228.
  • Laroche, C.; Kerwin, S. M. “Efficient, Regioselective Access to Bicyclic Imidazo[1,2-x]- Heterocycles via Gold and Base Promoted Cyclization of 1-Alkynylimidazoles” J. Org. Chem. 2009, 74, 9229-9232.
  • Li, J.; Kaoud, T. S.; Laroche, C.; Dalby, K. N.; Kerwin, S. M. “Synthesis and Biological Evaluation of p53a Kinase-Targeting Dialkynylimidazoles.” Bioorg. Med. Chem. Lett.  2009, 19, 6293-6297.
  • Wang, X.; Stavchansky, S.; Kerwin, S. M.; Bowman, P. D. “Structure-activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities. Eur. J. Pharmacol. 2010, 635, 16-22.
  • Laroche, C.; Li, J.; Golzales, C.; David, W. M.; Kerwin, S. M. “Cyclization Kinetics and Biological Evaluation of an Anticancer 1,2-Dialkynylimidazole” Org. Biomol. Chem. 2010, 8, 1535 – 1539.
  • Yang, J.; Marriner, G. A.; Wang, X.; Bowman, P. D.; Kerwin, S. M.; Stavchansky, S. “Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPE) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE)” Bioorg. Med. Chem. 2010, 18, 5032-5038.
  • Laroche, C.; Li, J.; Kerwin, S. M. “Cytotoxic 1,2-Dialkynylimidazole-Based Aza-Enediynes:  Aza-Bergman Rearrangement Rates do not Predict Cytotoxicity” J. Med. Chem. 2011, 54, 5059-5069.
  • Yang, J.; Kerwin, S. M.; Bowman, P. P., Stavchansky, S. “Stability of Caffeic Acid Phenethyl Amide (CAPA) in Rat Plasma" Biomed. Chromatogr. 2012, 26, 594-598.
  • Schoonover, M.; Kerwin, S. M.“G-Quadruplex DNA Cleavage Preference and Identification of a Perylene Diimide G-Quadruplex Photocleavage Agent Using a Rapid Fluorescent Assay”  Bioorg. Med. Chem. 2012, 20, 6904–6918.
  • Omar, M. A.; Shaker, Y. M.; Galal, S. A.; Ali, M. M. Kerwin, S. M.; Li, J.; Tokuda, H.; Ramadan, R. A. El Diwani, H. I. “Synthesis and docking studies of novel antitumor benzimidazoles” Bioorg. Med. Chem. 2012, 20, 6989–7001.
  • Li, J.; Kaoud, T. S.; LeVieux, J.; Gilbreath, B.; Moharana, S.; Dalby, K, N.; Kerwin, S. M. “A fluorescence-based assay for p38a docking site binders: Identification of the Hypoxis natural product rooperol as a novel p38a kinase inhibitor” ChemBioChem, 2013, 14, 66–71.
  • Kerwin, S. M.; Cha, J. “A concise synthesis of rooperol and related 1,5-diarylpent-1-en-4-ynes” Tetrahedron Lett. 2014, 55, 137-141.
  • Yang, J.; Bowman, P. D.; Kerwin, S. M.; Stavchansky, S. “Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in Sprague-Dawley rats” Biomed. Chromatogr. 2014, 28, 241-246.
  • Laroche, C.; Gilbreath, B.; Kerwin, S. M. “Exploring the synthetic utility of 1-alkynylimidazoles:  Regiocontrolled cyclization to diverse imidazoazines and imidazoazoles” Tetrahedron 2014 70, 4534-4539.
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Last Reviewed: January 28, 2015

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA

Email Address: pharmacy

Phone: 512-471-5263
Fax: 512-232-2606

College Mourns Creed Abell

Creed Wills Abell III, Ph.D., of Austin, died Tuesday, September 9, 2014.

Dr. Abell was internationally recognized for his contribution to neurochemistry and neurobiology. His work contributed to the scientific information and understanding regarding diseases such as Parkinson's and Alzheimer's and to the understanding of how aging affects neurological function.

>Read more.

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