Medicinal Chemistry

Faculty

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Kerwin, Sean M., Ph.D.
Professor of Med. Chem.
G.D. Searle & Co.
Endowed Fellowship in Pharmacy
BME 6.202C
512-471-5074
skerwin@austin.utexas.edu


Recent Publications

McKee, M. L., Kerwin, S. M. “Synthesis, Metal Ion Binding, and Biological Evaluation of New Anticancer 2-(2’-Hydroxyphenyl)benzoxazole Analogs of UK-1” Bioorg. Med. Chem. 2008, 16, 1775-1783.

Tuesuwan, B.; Kern, J. T.; Thomas, P. W.; Rodriguez, M. L.; Li, J.; David, W. M.; Kerwin, S. M “Simian Virus 40 Large T-antigen G-Quadruplex DNA Helicase Inhibition by G-Quadruplex DNA-Interactive Agents” Biochemistry 2008, 47, 1896-1909.

Laroche, C.; Li, J.; Freyer, M. S.; Kerwin, S. M. “Coupling Reactions of Bromoalkynes with Imidazoles Mediated by Copper Salts:  Synthesis of Novel N-Alkynylimidazoles” J. Org. Chem., 2008, 73, 6462-6465.

Mandal, S.; Li, W.-T.; Bai, Y.; Robertus, J. D.; Kerwin, S. M. “Synthesis of 2-Substituted 9-Oxa-guanines [5-Amino-oxazolo[5,4-d]pyrimidin-7(6H)-ones] and 9-Oxa-2-thio-xanthines [5-Mercapto-oxazolo[5,4-d]pyrimidin-7(6H)-ones]” Beilstein J. Org. Chem. 2008, 4(26), 1-5.

Marriner, W. A.; Kerwin, S. M. “An Improved Synthesis of N’-Nitroso-Nornicotine-5’-Acetate” J. Org. Chem. 200974,  2891-2892.

Laroche, C.; Li, J.; Kerwin, S. M. “Lithiation and Functionalization of N-Alkynylimidazoles at the 2-Position” Tetrahedron Lett. 2009, 50, 5194-5197.

Laroche, C.; Kerwin, S. M. “Efficient, Regioselective Access to Bicyclic Imidazo[1,2-x]- Heterocycles via Gold and Base Promoted Cyclization of 1-Alkynylimidazoles” J. Org. Chem. 2009, 74, 9229-9232.

Li, J.; Kaoud, T. S.; Laroche, C.; Dalby, K. N.; Kerwin, S. M. “Synthesis and Biological Evaluation of p53a Kinase-Targeting Dialkynylimidazoles.” Bioorg. Med. Chem. Lett.  2009, 19, 6293-6297.

Wang, X.; Stavchansky, S.; Kerwin, S. M.; Bowman, P. D. “Structure-activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities. Eur. J. Pharmacol. 2010, 635, 16-22.

Laroche, C.; Li, J.; Golzales, C.; David, W. M.; Kerwin, S. M. “Cyclization Kinetics and Biological Evaluation of an Anticancer 1,2-Dialkynylimidazole” Org. Biomol. Chem. 2010, 8, 1535 – 1539.

Yang, J.; Marriner, G. A.; Wang, X.; Bowman, P. D.; Kerwin, S. M.; Stavchansky, S. “Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPE) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE)” Bioorg. Med. Chem. 2010, 18, 5032-5038.

Laroche, C.; Li, J.; Kerwin, S. M. “Cytotoxic 1,2-Dialkynylimidazole-Based Aza-Enediynes:  Aza-Bergman Rearrangement Rates do not Predict Cytotoxicity” J. Med. Chem. 2011, 54, 5059-5069.

Schoonover, M.; Kerwin, S. M. “G-Quadruplex DNA Cleavage Preference and Identification of a Perylene Diimide G-Quadruplex Photocleavage Agent Using a Rapid Fluorescent Assay” Bioorg. Med. Chem. 2012, 20, 6904–6918.

Li, J.; Kaoud, T. S.; LeVieux, J.; Gilbreath, B.; Moharana, S.; Dalby, K, N.; Kerwin, S. M. “A fluorescence-based assay for p38a docking site binders: Identification of the Hypoxis natural product rooperol as a novel p38a kinase inhibitor” ChemBioChem, 2012, in press.

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Last Reviewed: December 11, 2012

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

Phone: 512-471-5263
Fax: 512-232-2606


Davis Among Provost's Teaching Fellows

Davis
Dr. Patrick Davis is among 20 leading faculty innovators who have been appointed as inaugural Provost's Teaching Fellows.
>Read more about this award.

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