Medicinal Chemistry

Faculty

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Lee, Seongmin, Ph.D.
Assistant Professor of Med. Chem.
PHR 3.206A
512-471-1785
seongminlee@austin.utexas.edu


Selected Publications
  1. The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β. Koag, M.; Nam, K.*; Lee, S.* Nucleic Acids Res. 2014, published online (DOI: 10.1093/nar/gku789)

  2. Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine. Koag, M.; Kou, Y.; Ouzon, H.; Lee, S.* Nucleic Acids Res. 2014, 42, 8755-8766.

  3. Streamlining bottom-up protein identification based on selective UVPD of chromophore-tagged histidine- and tyrosine-containing peptides. Aponte, J.; Vasicek, L.; Waminathan, J.; Xu, H.; Koag, M.; Lee, S.; Brodbelt, J. S.* Anal. Chem. 2014, 86, 6237-6244.

  4. Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β. Koag, M.; Lee, S.* J. Am. Chem. Soc. 2014136, 5707-5721.
  1. Structural basis for the promutagenicity of 8-bromoguanine. Koag, M.; Min, K.§; Lee, S.* J. Biol. Chem. 2014289, 6289-6298.

  2. Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4. Koag, M.; Cheun, Y.; Kou, Y.; Ouzon-Shubeita, H.; Min, K.§; Monzingo, A. F.; Lee, S.* 2013Steroids 79, 938-944.
  1. Unexpected opening of steroidal E-ring during hypoiodite-mediated oxidation. Kou, Y.; Lee, S.* 2013Tetrahedron Lett. 54, 4106-4109.

  2. Synthesis of C17-OH-north unit of ritterazine G via "Red-Ox" modifications of hecogenin acetate. Cheun, Y.; Kou, Y.; Stevenson, B.; Kim, H.; Koag, M.; Lee, S.* 2013Steroids 78, 639-643.
  1. Synthesis of 14',15'-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate. Kou, Y.; Cheun, Y.; Koag, M.;Lee, S.* 2013Steroids 78, 304-311.

  2. Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate.  Kou, Y.; Cheun, Y.; Koag, M.; Shin, A§.; Lee, S.* 2012Steroids 77, 1069-1074.
  1. Transetherification-mediated E-ring opening and stereoselective "Red-Ox" modification of furostan. Cheun, Y.; Koag, M.; Kou, Y.; Lee, S.*2012Steroids 77, 276-281.

  2. Discovery of hypoiodite-mediated aminyl radical cyclization lacking a nitrogen radical-stabilizing group: Application to synthesis of an oxazaspiroketal-containing cephalostatin analog. Koag, M.; Lee, S.* 2011 Org. Lett., 13, 4766–4769.
  1. Structure of Escherichia coli 3-Methyladenine DNA Glycosylase AlkA Bound to Undamaged DNA. Bowman, B. R.; Lee, S.; Wang, S.; Verdine, G. L. 2010J. Biol. Chem. 285, 35783-791.

  2. Atomic Substitution Reveals the Structural Basis for Substrate Adenine Recognition and Removal by Adenine DNA Glycosylase. Lee, S.; Verdine, G. L. 2009, Proc. Natl. Acad. Sci. USA 106, 18497.
  1. Synthesis of C14,15-Dihydro-25-epi North Unit of Cephalostatin 1 via Redox Modifications of Hecogenin Acetate. Lee, S.; Jamieson, D.; Fuchs, P. L. Org. Lett. 2009, 11, 5.

  2. Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines. Lee, S.; LaCour, T. G.; Fuchs, P. L.Chem. Rev. 2009, 109, 2275.
  1. Synthesis and Structure of Duplex DNA Containing the Genotoxic Nucleobase Lesion N7-Methylguanine. Lee, S.; Bowman, R. B.; Ueno, Y.; Verdine, G. L. J. Am. Chem. Soc.2008, 130, 11570.

  2. Trapping and Structural Elucidation of a Very Advanced Intermediate in the Lesion-extrusion Pathway of hOGG1. Lee, S.; Radom, C. T. Verdine, G. L. J. Am. Chem. Soc. 2008130, 7784.
  1. Structure of the Escherichia coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Facile Structure Determination of Lesion-Containing DNA. Bowman, B. R*.; Lee, S.* Wang, S.; Verdine, G. L. Structure 200816, 1166.


More information about Dr. Lee
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Last Reviewed: August 26, 2014

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

Phone:


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