Medicinal Chemistry



Lee, Seongmin, Ph.D.
Associate Professor of Med. Chem.
PHR 3.206A

Selected Publications
  1. The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β. Koag, M.; Nam, K.*; Lee, S.* Nucleic Acids Res. 2014, published online (DOI: 10.1093/nar/gku789)

  2. Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine. Koag, M.; Kou, Y.; Ouzon, H.; Lee, S.* Nucleic Acids Res. 2014, 42, 8755-8766.

  3. Streamlining bottom-up protein identification based on selective UVPD of chromophore-tagged histidine- and tyrosine-containing peptides. Aponte, J.; Vasicek, L.; Waminathan, J.; Xu, H.; Koag, M.; Lee, S.; Brodbelt, J. S.* Anal. Chem. 2014, 86, 6237-6244.

  4. Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β. Koag, M.; Lee, S.* J. Am. Chem. Soc. 2014136, 5707-5721.
  1. Structural basis for the promutagenicity of 8-bromoguanine. Koag, M.; Min, K.§; Lee, S.* J. Biol. Chem. 2014289, 6289-6298.

  2. Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4. Koag, M.; Cheun, Y.; Kou, Y.; Ouzon-Shubeita, H.; Min, K.§; Monzingo, A. F.; Lee, S.* 2013Steroids 79, 938-944.
  1. Unexpected opening of steroidal E-ring during hypoiodite-mediated oxidation. Kou, Y.; Lee, S.* 2013Tetrahedron Lett. 54, 4106-4109.

  2. Synthesis of C17-OH-north unit of ritterazine G via "Red-Ox" modifications of hecogenin acetate. Cheun, Y.; Kou, Y.; Stevenson, B.; Kim, H.; Koag, M.; Lee, S.* 2013Steroids 78, 639-643.
  1. Synthesis of 14',15'-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate. Kou, Y.; Cheun, Y.; Koag, M.;Lee, S.* 2013Steroids 78, 304-311.

  2. Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate.  Kou, Y.; Cheun, Y.; Koag, M.; Shin, A§.; Lee, S.* 2012Steroids 77, 1069-1074.
  1. Transetherification-mediated E-ring opening and stereoselective "Red-Ox" modification of furostan. Cheun, Y.; Koag, M.; Kou, Y.; Lee, S.*2012Steroids 77, 276-281.

  2. Discovery of hypoiodite-mediated aminyl radical cyclization lacking a nitrogen radical-stabilizing group: Application to synthesis of an oxazaspiroketal-containing cephalostatin analog. Koag, M.; Lee, S.* 2011 Org. Lett., 13, 4766–4769.
  1. Structure of Escherichia coli 3-Methyladenine DNA Glycosylase AlkA Bound to Undamaged DNA. Bowman, B. R.; Lee, S.; Wang, S.; Verdine, G. L. 2010J. Biol. Chem. 285, 35783-791.

  2. Atomic Substitution Reveals the Structural Basis for Substrate Adenine Recognition and Removal by Adenine DNA Glycosylase. Lee, S.; Verdine, G. L. 2009, Proc. Natl. Acad. Sci. USA 106, 18497.
  1. Synthesis of C14,15-Dihydro-25-epi North Unit of Cephalostatin 1 via Redox Modifications of Hecogenin Acetate. Lee, S.; Jamieson, D.; Fuchs, P. L. Org. Lett. 2009, 11, 5.

  2. Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines. Lee, S.; LaCour, T. G.; Fuchs, P. L.Chem. Rev. 2009, 109, 2275.
  1. Synthesis and Structure of Duplex DNA Containing the Genotoxic Nucleobase Lesion N7-Methylguanine. Lee, S.; Bowman, R. B.; Ueno, Y.; Verdine, G. L. J. Am. Chem. Soc.2008, 130, 11570.

  2. Trapping and Structural Elucidation of a Very Advanced Intermediate in the Lesion-extrusion Pathway of hOGG1. Lee, S.; Radom, C. T. Verdine, G. L. J. Am. Chem. Soc. 2008130, 7784.
  1. Structure of the Escherichia coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Facile Structure Determination of Lesion-Containing DNA. Bowman, B. R*.; Lee, S.* Wang, S.; Verdine, G. L. Structure 200816, 1166.

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Last Reviewed: October 6, 2014

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA

Email Address: pharmacy

Phone: 512-471-5263
Fax: 512-232-2606

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