Medicinal Chemistry



Liu, Hung-wen (Ben), Ph.D.
Professor of Med. Chem.
George H. Hitchings Regents Chair
In Drug Design
PHR 3.206B

Recent Publications

Chang, W.-c.; Dey, M.; Liu, P.; Mansoorabadi, S. O.; Moon, S.-J.; Zhao, Z. K.; Drennan, C. L.; Liu, H.-w. "Mechanistic Studies of an Enzymatic Unprecedented 1,2-Phosphono Migration Reaction." Nature 2013, 496, 114-118.

Ruszczycky, M. W.; Choi, S. H.; Liu, H.-w. "A Combined EPR-Kinetic Isotope Effect Study of Radical-Mediated Dehydrogenation of an Alcohol by the Radical SAM Enzyme DesII: Evidence for General Base Catalysis." Proc. Nat. Acad. Sci. USA 2013, 110, 2088-2093.

Sasaki, E.; Lin, C.-I.; Lin, K.-Y.; Liu, H.-w. "In vitro Characterization of LmbR and LmbN: Construction of the Octose 8-Phosphate Intermediate in Lincomycin A Biosynthesis." J. Am. Chem. Soc. 2012, 134, 17432-17435.

Huang, H.; Chang, W.-c.; Pai, P.-J.; Romo, A.; Mansoorabadi, S. O.; Russell, D. H.; Liu, H.-w. "Evidence for Radical-Mediated Catalyzed by HppE – A Study Using Cyclopropyl and Methylenecyclopropyl Substrate Analogues." J. Am. Chem. Soc. 2012, 134, 16171-16174. 

Chang, W.-c.; Xiao, Y.; Liu, H.-w.; Liu, P. "Mechanistic Studies of IspH-catalyzed Reaction: Elucidation of the Mode of Substrate Binding and Protonation." Angew Chem. Int. Ed. 2011, 50, 12304-12307.

Kim, H. J.; Ruszczycky, M. W.; Choi, S. H.; Liu, Y.-n.; Liu, H.-w. "An Enzyme-Catalyzed [4+2] Cycloaddition is a Key Step in the Biosynthesis of Spinosyn A." Nature 2011, 473, 109-112.

More information about Liu
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Last Reviewed: June 24, 2013

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA

Email Address: pharmacy

Phone: 512-471-5263
Fax: 512-232-2606

Provost's Teaching Fellows

Dr. Patrick Davis is among 20 leading faculty innovators who have been appointed as inaugural Provost's Teaching Fellows.

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