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Recent Publications
Thibodeaux, C. J.; Melançon, C. E.; Liu, H.-w. "Unusual Sugar Biosynthesis and Natural Product Glycodiversification." Nature 2007, 446, 1008-1016. Melançon, C. E., III; Liu, H.-w. "Engineered Biosynthesis of Macrolide Antibiotics Bearing the Non-Natural Deoxysugars 4-epi-D-mycaminose and 3-N-Monomethylamino-3-deoxy-D-fucose." J. Am. Chem. Soc. 2007, 129, 4896-4897. Mansoorabadi, S. O.; Thibodeaux, C. J.; Liu, H.-w. "The Diverse Roles of Flavin Coenzymes - Nature's Most Versatile Thespians." J. Org. Chem. 2007, 72, 6329-6342. Kim, H. J.; Pongdee, R.; Wu, Q.; Hong, L.; Liu, H.-w. "The Biosynthesis of Spinosyn in Saccharopolyspora spinosa: Synthesis of the Cross-Bridging Precursor and Identification of the Function of SpnJ." J. Am. Chem. Soc. 2007, 129, 14582-14584. Zhang, H.; White-Phillip, J. A.; Melançon, C. E. III; Yu, W.-l.; Kwon, H.-j.; Liu, H.-w. "Elucidation of the Kijanimicin Gene Cluster: Insights into the Biosynthesis of Spirotetronate Antibiotics and Nitrosugars." J. Am. Chem. Soc. 2007, 129, 14670-14683. Thibodeaux, C. J.; Mansoorabadi, S. O.; Kittleman, W.; Chang, W.-c.; Liu, H.-w. "Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase (IDI-2) from Staphylococcus aureus." Biochemistry, 2008, 47, 2547-2558. Hong, L.; Zhao, Z.; Melançon, C. E., III; Zhang, H.; Liu, H.-w. "In Vivo Characterization of the Enzymes Involved in TDP-D-Forosamine Biosynthesis in the Spinosyn Pathway of Saccharopolyspora spinosa." J. Am. Chem. Soc. 2008, 130, 4954-4967. Tao, Z.; Gao, P.; Hofmann, D. W.; Liu, H.-w. "Domain C of Human Poly(ADP-ribose) Polymerase-1 is Important for Enzyme Activity and Contains a Novel Zinc-Ribbon Motif." Biochemistry 2008, 47, 5804-5813. Mirica, L. M.; McCusker, K. P.; Munos, J. W.; Liu, H.-w.; Klinman, J. P. "18O Kinetic Isotope Effects in Non-Heme Iron Enzymes: Probing the Nature of Fe/O2 Intermediates." J. Am. Chem. Soc. 2008, 130, 8122-8123. Thibodeaux, C. J.; Melancon, C. E., III.; Liu, H.-w. "Natural Product Sugar Biosynthesis and Enzymatic Glycodiversification." Angew. Chem. Int. Ed. 2008, 47, 9814-9859. Munos, J. W.; Pu, X.; Mansoorabadi, S. O.; Kim, H. J.; Liu, H.-w. "A Secondary Kinetic Isotope Effect Study of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase-catalyzed Reaction: Evidence for a Retroaldol-Aldol Rearrangement." J. Am. Chem. Soc. 2009, 131, 2048-2049. Thibodeaux, C. J.; Liu, H.-w. "Unraveling the Mechanisms of Isoprenoid Biosynthetic Tao, Z.; Gao, P.; Liu, H.-w. "Identification of ADP-Ribosylation Sites in the PARP-1 Tao, Z.; Gao, P.; Liu, H.-w. "Studies of the Expression of Human Poly(ADP-ribose) Ogasawara, Y.; Liu, H.-w. "Biosynthetic Studies of Aziridine Formation in the Azicemicins." J. Am. Chem. Soc. 2009, 131, 18066-18068. Ruszczycky, M. W.; Choi, S. H.; Liu, H.-w. "Stoichiometry of the Redox Neutral Kim, H. J.; White-Phillip, J. A.; Ogasawara, Y.; Shin, N.; Isiorho, E. A.; Liu, H.-w. "The
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Division Information
Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113
Email Address: pharmacy
@www.utexas.edu
Phone:

Dr. Patrick Davis, senior associate dean and professor of medicinal chemistry, is one of five University of Texas at Austin faculty members cited to receive a President's Associates Teaching Excellence Award.
>Read more about this award.