Medicinal Chemistry

Faculty

Photo

Liu, Hung-wen (Ben), Ph.D.
Professor of Med. Chem.
George H. Hitchings Regents Chair
In Drug Design
PHR 3.206B
512-232-7811
liuh31@austin.utexas.edu


Recent Publications

Thibodeaux, C. J.; Melançon, C. E.; Liu, H.-w. "Unusual Sugar Biosynthesis and Natural Product Glycodiversification." Nature 2007, 446, 1008-1016.

Melançon, C. E., III; Liu, H.-w. "Engineered Biosynthesis of Macrolide Antibiotics Bearing the Non-Natural Deoxysugars 4-epi-D-mycaminose and 3-N-Monomethylamino-3-deoxy-D-fucose." J. Am. Chem. Soc. 2007, 129, 4896-4897.

Mansoorabadi, S. O.; Thibodeaux, C. J.; Liu, H.-w. "The Diverse Roles of Flavin Coenzymes - Nature's Most Versatile Thespians." J. Org. Chem. 2007, 72, 6329-6342.

Kim, H. J.; Pongdee, R.; Wu, Q.; Hong, L.; Liu, H.-w. "The Biosynthesis of Spinosyn in Saccharopolyspora spinosa: Synthesis of the Cross-Bridging Precursor and Identification of the Function of SpnJ." J. Am. Chem. Soc. 2007, 129, 14582-14584.

Zhang, H.; White-Phillip, J. A.; Melançon, C. E. III; Yu, W.-l.; Kwon, H.-j.; Liu, H.-w. "Elucidation of the Kijanimicin Gene Cluster: Insights into the Biosynthesis of Spirotetronate Antibiotics and Nitrosugars." J. Am. Chem. Soc. 2007, 129, 14670-14683.

Thibodeaux, C. J.; Mansoorabadi, S. O.; Kittleman, W.; Chang, W.-c.; Liu, H.-w. "Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase (IDI-2) from Staphylococcus aureus." Biochemistry, 2008, 47, 2547-2558.

Hong, L.; Zhao, Z.; Melançon, C. E., III; Zhang, H.; Liu, H.-w. "In Vivo Characterization of the Enzymes Involved in TDP-D-Forosamine Biosynthesis in the Spinosyn Pathway of Saccharopolyspora spinosa." J. Am. Chem. Soc. 2008, 130, 4954-4967.

Tao, Z.; Gao, P.; Hofmann, D. W.; Liu, H.-w. "Domain C of Human Poly(ADP-ribose) Polymerase-1 is Important for Enzyme Activity and Contains a Novel Zinc-Ribbon Motif." Biochemistry 2008, 47, 5804-5813.

Mirica, L. M.; McCusker, K. P.; Munos, J. W.; Liu, H.-w.; Klinman, J. P. "18O Kinetic Isotope Effects in Non-Heme Iron Enzymes: Probing the Nature of Fe/O2 Intermediates." J. Am. Chem. Soc. 2008, 130, 8122-8123.

Thibodeaux, C. J.; Melancon, C. E., III.; Liu, H.-w. "Natural Product Sugar Biosynthesis and Enzymatic Glycodiversification." Angew. Chem. Int. Ed. 2008, 47, 9814-9859.

Munos, J. W.; Pu, X.; Mansoorabadi, S. O.; Kim, H. J.; Liu, H.-w. "A Secondary Kinetic Isotope Effect Study of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase-catalyzed Reaction: Evidence for a Retroaldol-Aldol Rearrangement." J. Am. Chem. Soc. 2009, 131, 2048-2049.

Thibodeaux, C. J.; Liu, H.-w. "Unraveling the Mechanisms of Isoprenoid Biosynthetic
Enzymes: Mechanistic Studies of the Early Stage Enzymes." Chimia 2009, 63, 334-339.

Tao, Z.; Gao, P.; Liu, H.-w. "Identification of ADP-Ribosylation Sites in the PARP-1
Automodification Domain: Analysis and Implications." J. Am. Chem. Soc. 2009, 131,
14258-14260.

Tao, Z.; Gao, P.; Liu, H.-w. "Studies of the Expression of Human Poly(ADP-ribose)
Polymerase-1 in Saccharomyces cerevisiae and Identification of PARP-1 Substrates by Yeast Proteome Microarray Screening." Biochemistry, 2009, 48, 11745-11754.

Ogasawara, Y.; Liu, H.-w. "Biosynthetic Studies of Aziridine Formation in the Azicemicins." J. Am. Chem. Soc. 2009, 131, 18066-18068.

Ruszczycky, M. W.; Choi, S. H.; Liu, H.-w. "Stoichiometry of the Redox Neutral
Deamination and Oxidative Dehydrogenation Reactions Catalyzed by the Radical SAM Enzyme DesII." J. Am. Chem. Soc. 2010, 132, 2359-2369.

Kim, H. J.; White-Phillip, J. A.; Ogasawara, Y.; Shin, N.; Isiorho, E. A.; Liu, H.-w. "The
Biosynthesis of Spinosyn in Saccharopolyspora spinosa: Synthesis of the Methylated
Rhamnose and Characterization of the Functions of SpnH, SpnI, and SpnK." J. Am. Chem. Soc. 2010, 132, 2901-2903.


More information about Liu
> Lab Group (Personal Pages)
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Last Reviewed: May 5, 2010

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@www.utexas.edu

Phone:


Davis Awarded for Teaching Excellence

Davis
Dr. Patrick Davis, senior associate dean and professor of medicinal chemistry, is one of five University of Texas at Austin faculty members cited to receive a President's Associates Teaching Excellence Award.
>Read more about this award.

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