Medicinal Chemistry

Faculty

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Whitman, Christian P., Ph.D.
Division Head of Med. Chem.
Romeo T. Bachand, Jr. Regents Professor
BME 6.202A
512-471-6198
whitman@austin.utexas.edu


Publications

Burks, E.A., Yan, W., Johnson, Jr., W.H., Li, W., Schroeder, G.K., Min, C., Gerratana, B., Zhang, Y., and Whitman, C.P., "Kinetic, Crystallographic, and Mechanistic Characterization of TomN:  Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway" Biochemistry (in press). 

Guo, Y., Serrano, H., Johnson, Jr., W.H., Ernst, S., Hackert, M.L., and Whitman, C.P., "Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase:  Implications for the Catalytic and Inactivation Mechanisms" Bioorg Chem. 39, 1-9 (2011).

Almrud, J.J., Dasgupta, R., Czerwinski, R.M., Kern, A.D., Hackert, M.L., and Whitman, C.P., "Kinetic and structural characterization of DmpI from Helicobacter pylori and Archaeoglobus fulgidus, two 4-oxalocrotonate tautomerase family members", Bioorg Chem. 38, 252-259 (2010). 

Burks, E.A., Fleming, C.D., Mesecar, A.D., Whitman, C.P., and Pegan, S.D., "Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily" Biochemistry 49, 5016-5027 (2010).

Poelarends, G.J. and Whitman, C.P. "Mechanistic and Structural Studies of Microbial Dehalogenases:  How Nature Cleaves a Carbon-Halogen Bond".  In Comprehensive Natural Products Chemistry II Chemistry and Biology; Mander, L., Liu, H.-w. Eds.; Elsevier: Oxford, 2010; volume 8, pp. 89-123.

Whitman, C.P. "Overview and Introduction" In Comprehensive Natural Products Chemistry II Chemistry and Biology; Mander, L., Liu, H.-w. Eds.; Elsevier: Oxford, 2010; volume 8, pp. 1-7.

Srivastava, D., Zhu, W., Johnson, Jr., W.H., Whitman, C.P., Becker, D.F., and Tanner, J.J., "Structure of the Proline Utilization A Proline Dehydrogenase Domain Inactivated by N-Propargylglycine Provides Insight into Conformational Changes Induced by Substrate Binding and Flavin Reduction", Biochemistry 49, 560-569 (2010).

Robertson, B.A., Schroeder, G.K., Jin, Z., Johnson, K.A., and Whitman, C.P. "Pre-Steady State Kinetic Analysis of cis-3-Chloroacrylic Acid Dehalogenase:  Analysis and Implications", Biochemistry 48, 11737-11744 (2009).

Sevastik, R., Whitman, C.P. and Himo, F. "Reaction Mechanism of cis-3-Chloroacrylic Acid Dehalogenase - A Theoretical Study", Biochemistry 48, 9641-9649 (2009)

de Jong, R.M., Bazzacco, P., Poelarends, G.J., Johnson, Jr., W.H., Kim, Y.-J., Burks, E.A., Serrano, H., Thunnissen, A.-M.W.H., Whitman, C.P., Dijkstra, B.W. "Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase: Structural Basis for Substrate Specificity and Inactivation by (R)-Oxriane-2-carboxylate", J. Biol. Chem. 282, 2440-2449 (2007).
 
Gunsch, C.K., Kinney, K.A., Szaniszlo, P.J., Whitman, C.P. "Relative Gene Expression Quantification in a Fungal Gas-Phase Biofilter", Biotechnol. Bioeng. 98, 101-111 (2007).

Poelarends, G.J., Serrano, H., Johnson, Jr., W.H., and Whitman, C.P "The Phenylpyruvate Tautomerase Activity of trans-3-Chloroacrylic Acid Dehalogenase: Evidence for an Enol Intermediate in the Dehalogenase Reaction?",  Biochemistry 46, 9596-9604 (2007).

Wang, S.C, Johnson, Jr., W.H., Czerwinski, R.M., Stamps, S.L., and Whitman, C.P. "Kinetic and Stereochemical Analysis of YwhB, a 4-Oxalocrotonate Tautomerase Homologue in Bacillus subtilis:  Mechanistic Implications for the YwhB- and 4-Oxalocrotonate Tautomerase-catalyzed Reactions", Biochemistry, 46, 11919-11929 (2007).

White, T.A, Johnson, Jr., W.H., Whitman, C.P., and Tanner, J.J. "Structural Basis for the Inactivation of Thermus thermophilus Proline Dehydrogenase by N-Propargylglycine", Biochemistry, 47, 5573-5580 (2008)

Poelarends, G.J., Serrano, H., Person, M.D., Johnson, Jr., W.H., and Whitman, C.P. "Characterization of Cg10062 from Corynebacterium glutamicum:  Implications for the Evolution of cis-3-Chloroacrylic Acid Dehalogenase Activity in the Tautomerase Superfamily", Biochemistry 47, 8139-8147 (2008).

Robertson, B.A., Johnson, Jr., W.H., Lo, S. H.-H., and Whitman, C.P. "Inactivation of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue in Corynebacterium glutamicum,by (R)- and (S)-Oxirane-2-carboxylate:  Analysis and Implications", Biochemistry 47, 8796-8803 (2008)

Poelarends, G.J. and Whitman, C.P. "The Chemical Versatility of the b-a-b Fold:  Catalytic Promiscuity and Divergent Evolution in the Tautomerase Superfamily", Cell. Mol. Life Sci. 65, 3606-3618 (2008).

Pegan, S.D., Serrano, H., Whitman, C.P., and Mesecar, A.D., "Structural and Mechanistic Analysis of trans-3-Chloroacrylic Acid Dehalogenase Activity", Acta Crystallogr. D Biol. Crystallogr. 64, 1277-1282 (2008). 


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Last Reviewed: July 11, 2011

Division Information

Mailing Address:
The University of Texas
at Austin
Medicinal Chemistry
BME 6.202
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

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