MARIA A. CROYLE, Ph.D.

University of Texas at Austin
College of Pharmacy
Division of Pharmaceutics
PHR 4.214D
Austin, TX 78712
Phone: 512-471-1972
e-mail: macroyle@mail.utexas.edu


EDUCATION
1997-2000 University of Pennsylvania Institute for Human Gene Therapy, Philadelphia, PA.
Postdoctoral Research Fellow. Recipient of National Research Service Award
Research advisor: James M. Wilson
1997 University of Michigan, Ann Arbor, MI. PhD., Pharmaceutics
Thesis Advisor: Gordon L. Amidon
1994 University of Michigan, Ann Arbor, MI. M.S. Pharmaceutics.
1992 University of Pittsburgh, Pittsburgh, Pa. B.S. Pharmacy
Licensed Pharmacist in Pennsylvania and Michigan



PUBLICATIONS
Croyle, M. A., Chirmule, N., Zhang, Y. and James M. Wilson. "Stealth" Adenoviruses Blunt Cell Mediated and Humoral Immune Responses Against the Virus and Allow for Significant Gene Expression upon Readministration for Gene Therapy to the Lung. J. Virol. 2001 (in press)

Croyle, M. A., Yu, Q. C. and Wilson, J. M. Development of a Rapid Method for the PEGylation of Adenoviruses with Enhanced Transduction and Improved Stability Under Harsh Storage Conditions. Human Gene Therapy. 11(12) (2000) 1721-1730.

Yu QC, Ma X, Croyle M, Qu G, Huang J, Gao GP, Hughes J, Wilson JM. Electron microscopic evaluation of vector quality for gene therapy. Microsc Microanal (2000) 6:858-859

Croyle, M. A., Anderson, D. J., Roessler, B. J., and Amidon, G. L. Development of a Highly Efficient Purification Process for Recombinant Adenoviral Vectors for Oral Gene Delivery. Pharm. Dev. Technol. 3(3) (1998) 365-372.

Croyle, M. A., Roessler, B. J., Davidson, B. L., Hilfinger, J. M., and Amidon, G. L. Factors that Influence Stability of Recombinant Adenoviral Preparations for Human Gene Therapy Pharm. Dev. Technol. 3(3) (1998) 373-383.

Croyle, M.A., Roessler, B. J., Hsu, C-P., Sun, R. and Amidon, G. L. Beta Cyclodextrins Enhance Adenoviral-Mediated Gene Delivery to the Intestine. Pharm. Res. 15(9) (1998) 1348-1355.

Croyle, M.A., Stone, M., Amidon, G. L., and Roessler, B. J. In vitro and In vivo Assessment of Adenovirus 41 as a Vector for Gene Delivery to the Intestine. Gene Therapy, 5 (1998) 645-654.

Croyle, M.A., Walter, E., Janich, S., Roessler, B. J., and Amidon, G. L.. Role of Integrin Expression in Adenovirus-Mediated Gene Delivery to the Intestinal Epithelium. Human Gene Therapy. 9(4) (1998) 561-573.

Walter, E., Croyle, M. A., Davidson, B. L., Roessler, B. J., Hilfinger, J. M., Amidon, G. L. Adenovirus-mediated Gene Transfer to Intestinal Epithelial Cells as a Potential Approach for Oral Delivery of Peptides and Proteins. J. Control. Rel. 46 (1997) 75-87.

Walter, E., Croyle, M. A., Roessler, B. J., and Amidon, G. L. The Absence of Accessible Vitronectin Receptors in Differentiated Tissue Hinders Adenoviral-Mediated Gene Transfer to the Intestinal Epithelium In Vitro. Pharm. Res. 14(9) (1997) 1216-1222.




PROFESSIONAL ASSOCIATIONS
2001American Society for Microbiology
2000-Pr.Juvenile Diabetes Association
2000-Pr.American Association of Colleges of Pharmacy
1998-Pr. American Society of Gene Therapy
1994-Pr.Controlled Release Society
1993-Pr. American Association of Pharmaceutical Scientists
1990-Pr.Rho Chi Pharmaceutical Honor Society
1988-93 American Pharmaceutical Association, Academy of Students of Pharmacy, and PA Pharmaceutical Association