Pharmaceutics

Faculty

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Croyle, Maria A., Ph.D.
Alan W. Hamm Centennial
Fellowship in Pharmacy
Professor of Pharmaceutics
PHR 4.214D
512-471-1972

macroyle@austin.utexas.edu


News


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April 12, 2011 Jin Huk Choi Receives Award for Best Abstract in the Graduate Student Category during the College of Pharmacy's Celebration of Research Excellence Day.

Jin Huk Choi, a fourth year graduate student in Pharmaceutics, received recognition for his work titled " A Novel, Non-Invasive Method for Protective Vaccination Against Dangerous Pathogens ". He gave a 15 minute presentation of the work and received a certificate honoring his work.

January 20-21 and February 24, 2011 Dr. Croyle visits Vista Ridge High School in Cedar Park, Texas as a judge for their Science Fair.

Dr. Croyle spent 2 days talking to aspiring scientists about their research projects in chemistry, microbiology and health.  She then served as a lead judge in the Health/Medicine Section of the Austin Energy Regional Science Festival the following month.

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January 17, 2011 Ross Phan joins the Croyle lab as part of the Pharm.D., Ph.D. program!

Prior to her acceptance into the UT College of Pharmacy Pharm.D. program, Ms. Phan received a bachelor's degree in biology from Texas Christian University. She is currently working on developing novel formulations to improve the shelf life and potency of bacteria-based vaccines.

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December 2010 Dr. Croyle is nominated to the Pharmaceutical Sciences Electoral Committee in the American Association for the Advancement of Science.

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November 19, 2010 The Longhorn School Bus makes a stop at the Croyle lab!

Dr. Croyle and her group welcomed the sixth grade class of Zavala Elementary School in Austin to the College of Pharmacy by giving them and their teachers a tour of her laboratory. Students looked at cells in the microscope and learned about viruses and vaccines. The Longhorn bus program was sponsored by Pharmacy Council in collaboration with UT Senate to provide students with an idea of what it is like to be a pharmacy student.

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November 11, 2010 Wenwen Shen joins the Croyle lab.

Wenwen received a bachelor's degree in microbiology from Huazhong Agricultural University (HZAU) in Wuhan, China and was a high school biology teacher before coming to the United States where she received a Master's degree in Veterinary and Biomedical Science from the University of Nebraska.

November, 1, 2010 Dr. Croyle Discusses what it Takes to Make a Vaccine with Beta Beta Beta Biology Honors Society at UT.

Dr. Croyle spent the evening sharing her experiences while developing a vaccine for Ebola with students in the College of Natural Sciences considering a career in academic research.

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October 2010 Jin Huk Choi passes qualifying exam and presents work at National Keystone Research Conference in Seattle, Washington.

Jin Huk Choi, Pharmaceutics graduate student, presented preliminary data and a plan for completing his research project titled "Evaluation of the Oral Mucosa as a Site for Protective Immunization Against Ebola Zaire with an Adenovirus Serotype 5-Based Vaccine" to his committee members which they agreed was quite novel and would provide significant insight into vaccine development for Ebola and other pathogens. That same day, he left for the Immunological Mechanisms of Vaccination meeting and presented his work on a sublingual vaccine for Ebola to international experts in the field the following day.

October 2010 Dr. Croyle Travels to the National Institutes of Health to Serve on Several Study Sections.

Dr. Croyle provided expertise in the area of drug and vaccine development and the design of in vivo studies to a scientific panel at the NIH in an effort to evaluate research proposals for funding.

September 20, 2010 Dr. Croyle Travels to the Public Health Agency of Canada to Celebrate Completion of Collaborative Nasal Vaccine Project with Drs. Gary Kobinger and Amine Kamen.

Dr. Croyle presented her work on the formulation and characterization of a nasal vaccine for Ebola to officials from the Canadian Chemical, Biological, Radiological-Nuclear and Explosives (CBRNE) Research and Technology Initiative (CRTI). Dr. Kobinger discussed work from his group in characterizing the immune response and potency of the formulated vaccine. Dr. Kamen then discussed the efforts of his group to develop an efficient large-scale production method for the vaccine. Overall, the project was considered to be a success and a proposal for clinical testing of the vaccine in Canada will be submitted in early 2011.

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July 23, 2010 The Croyle Lab Participates in the University of Texas Honors Colloquium.

Dr. Croyle met with approximately 40 honors students from high schools throughout the state of Texas to discuss her work on an Ebola vaccine. Stephen Schafer, and Jin Huk Choi then conducted a lab tour. Students were shown first hand how the vaccine was made in cell culture and the various assays that must be performed on the preparation before it can be used in scientific studies.

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July 23, 2010 Piyanuch Wonganan defends her thesis!

After 5 years of hard work, Piyanuch Wonganan defended her Ph.D thesis titled "A Mechanistic Study of How Adenovirus Infection Alters the Expression and Function of Cytochrome P450 3A". After graduation, Piyanuch plans to return to her home in Thailand and assume a faculty position after completing a postdoctoral research fellowship in the United States.

June 22-23, 2010 Dr. Croyle attends International Filovirus Medical Countermeasures Workshop.

Dr. Croyle participated in a joint meeting of the scientific community involved with the development of therapeutics for filovirus infection, the department of defense and other funding agencies that support their work. The purpose of the meeting was to identify current hurdles that prevent research in this area from progressing.

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June, 2010 Stephen Schafer wins UT College of Pharmacy Staff Merit Award.

Mr. Schafer was recognized for his dedication, service, and outstanding job performance at the annual College of Pharmacy Staff luncheon held at the Broken Spoke Saloon where attendees were treated to a traditional Texas meal, took part in country-western dance lessons, and enjoyed the music of Gary P. Nunn. Later that month, Stephen was promoted from Laboratory Technical Services Supervisor to Program Coordinator for the Croyle lab for all his hard work.

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April 27, 2010 Dr. Croyle travels to the Massachusetts Institute of Technology to Review Grant Proposals for the National Academy of Finalnd.

Dr. Croyle provided expert advice in the areas of gene and cell therapy to the scientific counsel of Finland and assisted with evaluation of grant proposals submitted to this agency for funding research projects in Finland.

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Front row (L to R) Deepak Jain, Ph.D. (Tengion, Inc.), Fouad Atouf, Ph.D. (USP Scientific Liaison), William Tente (Chair of Committee), Anthony A. G. Ridgway, Ph.D. (Health Canada) Middle Row: Darin J. Weber, Ph.D. (The Biologics Consulting Group), Maria Croyle (The University of Texas at Austin), Joseph Gallelli, Ph.D. (Biotechnology Development at the National Institutes of Health), Beth M. Hutchins, Ph.D. (Schering Plough Biopharma), Nicole Provost, Ph.D. (Dendreon Corporation) Back Row: Nancy H. Collins, Ph.D. (University of Toledo), Scott R. Burger, M.D. (Advanced Cell & Gene Therapy, LLC), Elizabeth J. Read, M.D. (Cell and Tissue Therapies, Blood Systems Research Institute), Ann A. Jakubowski, M.D., Ph.D. (Memorial Sloan Kettering Cancer Center), Gary C. duMoulin, Ph.D. (Genzyme Biosurgery)

March 9, 2010 Dr. Croyle travels to the United States Pharmacopeia and ends 5 year term serving on the Biologics and Biotherapeutics Cell, Gene and Tissue Therapies Council of Experts.

During her time on this committee Dr. Croyle worked with national and international scientists from academic, government and industrial settings to evaluate and establish standards for several therapeutic products. During her tenure on this committee, she also made significant contributions to two general chapters of the current USP/NF: <1047> Gene Therapy Products and <1098> Validation of Research Test Kits.

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March 1, 2010 Albert Pai and Samaneh Poureli receive University of Texas Undergraduate Research Fellowships to support their work in the Croyle lab!

Albert Pai (College of Natural Sciences) received an award for his work on developing novel methods to modify virus capsids to shield them from the immune system. Albert will graduate Spring 2011 with a BS degree in biochemistry and plans to attend medical school. Samaneh (College of Pharmacy) received an award for her work on developing novel formulations for a buccal vaccine. Samaneh will graduate in the Spring of 2012 with a Doctor of Pharmacy degree.

February 22, 2010 Dr. Croyle presents Research on an Oral form of an Ebola Vaccine at the National Biodefense and Emerging Diseases Research Meeting in Baltimore, M.D.

Dr. Croyle discussed data generated by her research group to develop an oral vaccine for Ebola. At this meeting Dr. Croyle presented data to national and international scientists and government officials that demonstrated for the first time that administration of the vaccine to the sublingual mucosa could be an easy and effective way to vaccinate against Ebola. The meeting was sponsored by the American Society for Microbiology.

January 12, 2010 Dr. Croyle travels to Washington D.C. to discuss progress of Ebola Vaccine at the National Institutes of Health.

Dr. Croyle met with scientists and clinicians in the Vaccine Research Center of the National Institute for Allergy and Infectious Disease to discuss results generated by her laboratory in their quest for a vaccine against Ebola that is easy to administer. Her talk was well received and there was much interest from the clinical staff about the timeline that the project would follow.

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December 11, 2009 Dr. Croyle takes part in a local panel on H1N1 policies sponsored by the Lyndon B. Johnson School of Public Affairs Center for Health and Social Policy titled "Managing the H1N1 Virus:Immunization Development and Distribution Policy" at Brackenridge Hospital.

This event consisted of a panel of state and local health officials (Adolfo Valadez, Assistant Commissioner for Prevention and Preparedness Services at the Texas Department of State Health Services; Dr. Thomas Erlinger, Director of Research Administration, Infection Prevention and Epidemiology, Seton Hospital Network) and those in the scientific community with expertise in the science and management of infectious disease (Dr. Maria Croyle, UT Pharmacy and Dr. Lauren Meyers, UT Integrative Biology) moderated by Dr. Benedicte Callan, CHASP Professor and formerly of the OECD. The audience was local health care providers, and those involved in public health legislation. Dr. Croyle discussed issues associated with production and testing of H1N1 vaccines that have serious effect on public health with local health care providers, and those involved in public health legislation that attended the discussion.

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November 1, 2009 Dr. Croyle takes a short break from the lab and runs the New York City Marathon!

On a cold and rainy Sunday morning, Dr. Croyle started her 26 mile race with 50,000 other international runners throughout the streets of New York's five boroughs: Staten Island, Brooklyn, Queens, the Bronx, and Manhattan. This was the 16th marathon race that she has completed.

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October 4-6, 2009 Dr. Croyle Discusses Progress of Ebola Vaccine at Third Annual Global Vaccine Conference Held in Singapore.

Dr. Croyle met with internationally recognized leaders in vaccine development, design and distribution for four days at the Ritz-Carlton, Millenia hotel Singapore to discuss issues associated with implementing novel vaccine delivery methods in the clinic. Dr. Croyle's talk, titled "Development of A Mucosal Vaccination Platform for Ebola" was also featured as part of the "Virtual Congress" that was videostreamed to subscribers in real time across the internet.

Ebola Cards
Ebola Cards

July 24, 2009 Croyle Welcomes 40 Outstanding High School Seniors to Visit Virus Laboratory

Twenty students fill a small lecture room chatting about what they have discovered while visiting the UT Austin campus. In rushes Dr. Maria Croyle, unbeknownst to them, with the announcement that something serious has happened in their small village here within this room and one person has fallen ill. While doing this she hands a somewhat shocked student a small card with a picture of the Ebola virus on it. She goes on to say that this individual rushes to her friends for help and in turn infects one of them (another student is given an Ebola card). Before they know it, 90% of the students in the room are holding Ebola cards. The exercise ends with approximately 75% of those infected holding "death" cards. This was one of several exercises used to illustrate how lethal pathogens spread and affect small isolated populations. Croyle then talked to the students about how these infections impact the state of Texas and the United States with respect to public health and economic policies. The class then toured her laboratory and got to witness how her group produces a recombinant vaccine against the Ebola virus from infecting cells used to grow the virus to final purification steps.

The Honors Colloquium is an annual event during which The University of Texas at Austin opens it's doors to high school seniors primarily from Texas high schools that will eventually be named National Merit, National Achievement, or National Hispanic Finalists and Scholars, and compete for the university's honor programs. For more information about this program see http://www.utexas.edu/ugs/hc

Sandra Rrenteria & Maria Croyle
Maria Croyle & Sandra Renteria


Joe Dekker
Joe Dekker


Jin Huk Choi
Jin Huk Choi

 

May 27-30, 2009 The Croyle Lab Presents Three Papers on Vaccine Research at National American Society of Gene Therapy Meeting in San Diego

Three students from Dr. Croyle's lab had abstracts selected for presentation in the Infectious Diseases and Vaccines Section of the National ASGT meeting. 

Sandra Renteria, a P3 student who started in the lab prior to studying in the College as part of the Hispanic Center of Excellence program, presented her work titled "Effects of Concentration and Formulation on Adenovirus Stability and Infectious Titer during Actuation from Two Intranasal Delivery Devices".  Sandra received a travel scholarship from the College to support her trip and plans to submit this work to a peer-reviewed scientific journal by the end of the fall semester. 

Joe Dekker, a graduate student in the ICMB program, presented his work titled "An In Vitro and In Vivo Strategy for Optimization of a Recombinant Adenovirus-Based Ebola Vaccine for Nasal Administration".  Joe also plans to submit this work for publication soon. 

Jin Huk Choi, a Pharmaceutics graduate student, also received a travel award from the College to present his work titled "Development of a Recombinant Adenovirus-Based Ebola Vaccine for Oral Administration". 

Katie Lee, P1 student who also works in the lab, attended the meeting as part of her participation in the UT Intellectual Entrepreneurship Program for undergraduates in the College of Natural Sciences. To read more about Katie's experience in the IE program and her work in the Croyle lab, please visit her page.

Croyle and Curiel

Dr. David Curiel, Director of the UAB Gene Therapy Center (left) and Dr. Maria Croyle.

December 11, 2008 Dr. Croyle speaks at the UAB Gene Therapy Center
Dr. Croyle spent the day meeting with director Dr. David Curiel and other faculty, post-docs and graduate students actively working on clinical trials for genetic and vaccine-based therapies. The day ended with her seminar entitled, "Pharmacology, Toxicology and Delivery Issues Associated with Recombinant Adenovirus-based Vaccines". The presentation was co-sponsored by the UAB Department of Pharmacology and Toxicology.
Watch UT campaign video featuring Dr. Croyle

May 1, 2008     Croyle Receives Over $2.6 From National and International Granting Agencies to Develop a Vaccine Against Ebola

Piyanuch Wonganan

Piyanuch Wonganan

April 17, 2008     Wonganan Receives Award for Outstanding Research Achievement at College of Pharmacy Celebration of Research Excellence Day.

Piyanuch Wonganan, a third year graduate student in Pharmaceutics, received recognition for her work titled "Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus in Non-Human Primates".  She presented a 15 minute  presentation of the work and received a certificate stating the honor.  Piyauch was also recognized for this work at the national scientific meeting of the American Society of Gene Therapy.
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Evening banquet reception for participants in the biotechnology conference.
On the left (back to front): Hyo-Kyung Han (Chosun University), Maria Croyle (University of Texas at Austin), Svetlana Ermankova (Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia), Masahiro Murakami (Osaka Ohtani University, Japan). On the right (back to front): Tetsuya Ozeki (Tokyo University of Pharmacy and Life Sciences, Japan), Xiliang Zha (Fudan University, China), Hoo-Kyun Choi (Chosun University, Korea), Cheol-Hee Choi (Chosun University), Woon-Keun Oh (Chosun University), Hye-Gwang Jeong (Chosun University)

September 10-11, 2007     Dr. Croyle Discusses Virus Infection and Drug Metabolism with International Group of Researchers at Chosun University in South Korea.

Dr. Maria Croyle was invited to participate in an international conference titled "Recent Advances and Prospects in the Development of Combined Biotechnology Drugs" held at Chosun University in Gwangju, South Korea.  The symposium was sponsored by the College of Pharmacy and the Korean government to foster international collaboration in the area of biotechnology.  Dr. Croyle's talk was titled "Impact of Recombinant Viruses on Drug Metabolism".


BioKorea

Dr. Croyle, Dr. Tetsuya Ozeki and his graduate students from the Tokyo University of Pharmacy and Life Sciences as they leave Chosun University and head to Seoul Korea for the national scientific conference BioKorea 2007.

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September 12-14, 2007 Dr. Croyle Presents Work on PEGylated Adenoviruses to International Audience at BioKorea 2007 Conference.

Dr. Croyle was invited to participate in the international conference by Dr. Hyo-Kyung Han of Chosun University.  Croyle and Han met while working as graduate students in the laboratory of Dr. Gordon Amidon at the University of Michigan. Dr. Croyle's talk was titled "Pharmacology and Toxicology of Modified Recombinant Virus for Vaccine and Gene Transfer".  Dr. Croyle enjoyed exchanging ideas with conference participants and visiting the many sights in and near Seoul.

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Beautiful flowers and tulip fields of Amsterdam

 

April 22-25, 2007  Croyle Attends Pharmaceutical Sciences World Congress Conference"Optimizing Drug Therapy" An Imperative for World Health- in Amsterdam, The Netherlands.

Dr. Croyle discussed with the international audience her work in the area of virus infection and renal and hepatic drug metabolism.  Her  presentation was titled "A Single Dose of Recombinant Adenovirus Significantly Alters Hepatic and Renal Cytochrome P450 Expression and Function for 14 Days".  Dr. Croyle also enjoyed visiting the many sights in and near Amsterdam while attending the conference.


More information about Dr. Croyle
> Background & Training
> Dr. Croyle's CV (pdf)
> Teaching Interests
> Affiliations & Related Links
> Recent Publications
> Lab Group
> Return to Dr. Croyle's Home Page


Last Reviewed: March 31, 2014

Division Information

Mailing Address:
Pharmaceutics Division
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

Phone:
1-512-471-7182


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