Pharmaceutics

Faculty

Photo

Croyle, Maria A., Ph.D.
Glaxo Wellcome Professor
Professor of Pharmaceutics
PHR 4.214D
512-471-1972

macroyle@austin.utexas.edu


Lab Group Photo of Croyle Lab Group

Back Row (L to R)  Stephen Schafer, Program Coordinator, Wenwen Shen, Research Fellow, Jin Huk Choi, Pharmaceutics Graduate Student.
Front Row (L to R)  Piynauch Wonganan, Postdoctoral Fellow, Dr. Maria Croyle, Ross Phan, Pharm.D./Ph.D. candidate

Students Supervised:
2010-Pr. Ross Phan PharmD/PhD Candidate, College of Pharmacy
 

*** Ross recently joined the lab as a Pharm.D/Ph.D. candidate.  Her project focuses on the development stable of bacterial vaccines that can be administered by the buccal route.

2010 Emily Rosenfeld Research Intern, UT College of Natural Sciences
 

*** Emily is a student considering a graduate career in immunology.  She is working on a plasmid system to determine the molecular mechanism of virus suppression to cytochrome P450 enzymes in the liver.

2010 Michael Scott Research Rotation, College of Pharmacy
 

Michael spent a 6 week rotation validating the TR146 cell line as a viable in vitro model of the buccal mucosa.  

2009-10 Albert Pai Research Intern, UT College of Natural Sciences Honors Program
 

*** Albert is seeking BS Option III dual degrees in biochemistry and math.  He is working on a senior thesis titled "Development of an In Vitro Cell Culture system for rapidly characterizing the types of Immune Responses Induced by Novel Vaccine Candidates Delivered by the Buccal Route."

2009-10 Samaneh Pourali Research Intern, UT College of Pharmacy Honors Program
 

Project Title : Effect of Novel β-D-maltopyranosides to Preserve Adenovirus Structure and Infectivity during Actuation from Two Nasal Spray Delivery Devices and During Long-Term Storage at Several Temperatures.  

2009-10 Nadia Khan Research Intern, UT College of Natural Sciences
 

*** Nadia is a pre-med student working on a project that evaluates the effect that changes in Toll-like receptors play in the expression and function of hepatic CYP3A during virus infection. She spent summer 2010 in a gene therapy lab at Stanford as an Amgen Scholar.

2009 Trenicia  Olotu  Undergraduate Research Fellow, UT College of Natural Sciences
 

Project Title : Amplification of Genes that Regulate Expression of Hepatic CYP3A.

2009 Jobby John Undergraduate Research Fellow, UT College of Natural Sciences
 

Project Title : Assessment of the Toxicity Associated with Novel Adenovirus-Based Vaccine Conjugates.

2009 Gavin Best

Undergraduate Research Scholar (Duke University)
**Gavin is a biology major at Duke who chose to work in the lab during the summer to explore a career in translational research. 

 

Project Title : Assessment of the Biodistribution of Biochemically Modified Adenovirus-Based Vaccine Candidates for Ebola.  

2009 Tiffany Putsche Undergraduate Honors Program Fellow, UT College of Pharmacy
 

Project Title : Effect of Novel β-D-maltopyranosides to Preserve Adenovirus Structure and Infectivity during Actuation from Two Nasal Spray Delivery Devices and During Long-Term Storage at Several Temperatures.  

2008-09 Katie Lee Research Intern, UT Intellectual Internship Program
 

Project Title : Development of Novel Adenovirus Conjugates to Improve Oral Vaccine Potency.

2008-09 Evelyn Nash Undergraduate Problems Course in Biology
 

Project Title : Assessment of the Long-Term Stability of Adenovirus-Based Vaccines at Ambient Temperatures.

2008 Mariko Takakura Master's Student, Hoshi University, Tokyo, Japan
**Mariko's work is part of a collaboration between The University of Texas at Austin College of Pharmacy and Hoshi University.  Part of her research training occurs in Japan and part in Austin. 
 

Her project involves looking at phosphorylation patterns of the retinoid X receptor during viral infection in the liver.

2008 Jay Truitt

MD/PhD Student

 

Project Title :In vitro and in vivo mechanistic assessment of Changes in CYP3A in the Intestine following Viral Infection.

2008 Shelia Bal

Graduate Student (Molecular and Cellular Biology Program)
Co-advised with Adron Harris

 

Project Title :Systematic Knockdown of Genes Associated with Biochemical and Behavioral Aspects of Alcoholism using Novel Lentiviral Vectors.

2007-08 Ian McCoy

Undergraduate Research Fellow, UT College of Natural Sciences

 

Project Title : Characterization of novel methods for the production of AAV.

2008 Dennis Hu

Undergraduate Problems Course in Biochemistry

 

Project Title : Validation of a Bioassay to Assess the Potency of Adenovirus Vaccines.

2007-08 Elyor Sebbane

Undergraduate Research Intern

**Elyor was accepted into the UT McNair Scholars Program which is geared to provide students with the resources and skills to successfully obtain admission to a graduate school of their choosing.  He was awarded a competitive fellowship to support his summer research.

 

Project Title :"Assessment of the HB227 Cell Line as a Suitable In Vitro Model for Mechanistic Study of Changes in Intestinal Cytochrome P450 expression and function During Viral Infection" based upon a proposal he constructed.

2007-Pr. Jin Huk Choi

Pharmaceutics Graduate Student

 

Project Title :Characterization of the Immune Response after Oral Delivery of Novel Formulations of Recombinant Viruses.

2007-08 Courtney Clemens 

Undergraduate Research Fellow, UT Clinical Laboratory Medicine Program

 

Project Title : Assessment of the Suitability of Nasal Delivery Devises for an Ebola Virus Vaccine.  

2007-09 Sandra Renteria   Undergraduate Research Fellow, UT College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program
 

Project Title : Characterization of Formulations for Nasal Delivery of Vaccines.     

2006 John Andrade  Undergraduate Research Fellow, UT College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program
 

Project Title : Pharmacologic and Pharmacokinetic Studies of Docetaxel Alone and in Combination with Recombinant Adenovirus in Sprague Dawley Rats.     

2005 Lucia Imbrici   Postdoctoral Fellow (University of Napoli, Napels, Italy)
 

Project Title : Development of Novel  Materials for Masking the Immune Response Against Therapeutic Proteins.    

2005-08 Andrew Faso   Undergraduate Honors Program Fellow, UT College of Pharmacy
 

Project Title : Assessment of residual poly(ethylene) glycol in PEGylated Adenovirus Preparations and Identification of Modified Viral Proteins using a Colorimetric Assay and Polyacrylamide gel Electrophoresis.  

2005-10 Joseph Dekker   Graduate Student (Molecular and Cellular Biology Program)
 

Project Title : Characterization of Methods for Rapid Induction of Immunity to Biological Pathogens.  

2005 Erin Hartman

Undergraduate Research Intern

**Erin was a biochemistry major at the California Institute of Technology.  She was awarded a competitive fellowship (SURF - Summer Undergraduate Research Fellowship) based upon a proposal she wrote to work in the lab and explore a career in translational research. 

 

Project Title : Assessment of Cytochrome P450 Gene Expression During Adenovirus Infection in Kidney Cell Lines.  

2005-10 Piynauch Wonganan

Pharmaceutics Graduate Student Degree awarded 8/10

 

Project Title : Pharmacokinetic Characterization of the Immune Response and Biodistribution of PEGylated Adenovirus in Non-Human Primates.

2004-06 Erin Clark

Undergraduate Research Fellow, UT College of Natural Sciences

 

Honors Thesis:  Characterization of T Cell Immunity Following Intranasal Immunization Against Ebola Virus.  

***Erin was accepted in the Cell Biology Graduate Program at Harvard University, Fall 2006.

2004-5 Kristina Gonzalez

Undergraduate Research Fellow, UT College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program

  Project title: Analysis of Changes in CYP3A2 Gene Expression After Adenoviral Administration.  
2004 Selina Aguilar

Undergraduate Research Fellow, UT College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program

  Project title: Riboflavin: An Effective Agent for Controlled Inactivation of Recombinant Adenovirus for Analytical and Biological Use.  
2004 Matt Herpin Undergraduate Problems Course in Biochemistry
  Project title: Thermodynamic Properties of Adenovirus Capsid Proteins.
2003-04 Aida Alibegovic Undergraduate Research Fellow
  Project title: Characterization of Release Profiles of PEGylated Adenovirus from PLGA Microspheres.
2003-05 Hong Le Pharmaceutics Graduate Student
 

Thesis Title:Mechanistic Studies of Adenovirus-Mediated Changes in Renal Cytochromes P450.

2002-04 Xin Ming MS Pharmaceutics Degree Awarded  12/04
 

Thesis Title: Development and Validation of a Semi-Quantitative Reverse Transcription Polymerase Chain Reaction Assay to Detect Changes in Hepatic Cytochrome P450 Expression During Adenovirus Infection in the Rat.

2002-03 Harsha Mistry Undergraduate Research Fellow
  Project title: Effect of Polymer Size on the Pharmacokinetic Profiles of PEGylated Adenoviruses.
2002-03 Kelly Red Undergraduate Honors Program Fellow
  Project title: Effects of Adenoviral Infection on Renal Cytochrome P450 Protein Expression.
2001-02 Kayla Quick Undergraduate Research Problems Course
 

**Kayla received the UT College of Pharmacy Basic Science Award in recognition of her research on adenovirus aggregation characteristics.

Project title: ”Aggregation Phenomena of a First-Generation and a Helper Dependent Adenovirus for use in Gene Delivery.”
2001-05 Shellie Callahan Ph.D. Pharmaceutics Degree Awarded 12/05
  Thesis title: Recombinant Adenoviral-Mediated Alterations of Hepatic CYP3A2 and 2C11.

*** Shellie's dissertation was nominated by the College of Pharmacy for the UT Outstanding Dissertation Award.  Shellie currently holds a position in the Business Development group at CEDRA, Austin, TX and an adjunct faculty appointment in the Department of Biology at the University of Southern Indiana.

2000-01

Anne Vieira Degree awarded 12/01
  Thesis Title: The Suitability of Different Animal Models for Toxicological Assessment of Intravenously Administered Adenoviral Vectors
Ph.D. Dissertation Committees
2010 Shayna McGill candidacy 9/10
 

Thesis Title: Overcoming extracellular barriers to drug delivery: molecular and nanoparticle interactions in mucus.

2006 Haripriya Sridharan candidacy 9/06 Degree awarded 04/09
  Thesis Title: Role(s) of Non-Structural (NS) Protein 1 of Influenza B in Virus Replication (Department of Cellular and Molecular Biology)
2005 Chad McKee candidacy 2/05 Degree awarded 12/07
  Thesis Title: The Role of AKT in the Stability of XIAP and Prevention of Germ Cell Apoptosis (Department of Cellular and Molecular Biology)
2003 Raed Khashan Degree awarded 12/03
  Thesis Title: Refinement and Validation of BCUT Descriptors for Computer-Assisted Drug Delivery.
2001 Shirley Lu Degree awarded 12/04
  Thesis Title: The Role of Endocrine Factors in the Modulation of Cytochrome P450 by Cyclosporine.
2001 Bobby Troung Degree awarded 8/01
  Thesis Title: Development of an Insulin Pressurized Meter Dose Inhaler for Pulmonary Drug Delivery by Spray-Freezing into Cryogenic Vapor.
2000 Taekrho Kim candidacy 5/01 Degree awarded 12/02
  Thesis Title: The Effect of Lipoprotein Association on Cyclosporine Metabolism and Toxicity in Rats.
2000 Jinrong Liu candidacy 8/01 Degree awarded 12/02
  Thesis Title: The Roles of PXR and cAMP in Cyclosporine-Induced CYP3A Alterations.
2000 True Rogers candidacy 5/01 Degree awarded 12/02
  Thesis Title: Design, Development and Investigation of a Novel Cryogenic Spray-Freezing Process to Enhance the Dissolution of Poorly Water Soluble Drugs.


More information about Dr. Croyle
> Background & Training
> Teaching Interests
> Affiliations & Related Links
> Recent Publications
> News
> Return to Dr. Croyle's Home Page


Last Reviewed: August 27, 2014

Division Information

Mailing Address:
Pharmaceutics Division
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

Phone:
1-512-471-7182


Williams to Lead Journal

Dr. Bill Williams has been named editor-in-chief of AAPS PharmSciTech, the online research journal of the American Association of Pharmaceutical Scientists.

> Read more about this story.


index of the major headings: a b c d e f g h i j k l m n o p q r s t u v w x y z