Croyle, Maria A., Ph.D.
Alan W. Hamm Centennial Fellowship in Pharmacy
Associate Professor of Pharmaceutics
PHR 4.214D
512-471-1972
macroyle@mail.utexas.edu

*** Ross recently joined the lab as a Pharm.D/Ph.D. candidate.  Her project focuses on the development stable of bacterial vaccines that can be administered by the buccal route.

*** Emily is a student considering a graduate career in immunology.  She is working on a plasmid system to determine the molecular mechanism of virus suppression to cytochrome P450 enzymes in the liver.

Michael spent a 6 week rotation validating the TR146 cell line as a viable in vitro model of the buccal mucosa.  

*** Albert is seeking BS Option III dual degrees in biochemistry and math.  He is working on a senior thesis titled "Development of an In Vitro Cell Culture system for rapidly characterizing the types of Immune Responses Induced by Novel Vaccine Candidates Delivered by the Buccal Route."

Project Title : Effect of Novel β-D-maltopyranosides to Preserve Adenovirus Structure and Infectivity during Actuation from Two Nasal Spray Delivery Devices and During Long-Term Storage at Several Temperatures.  

*** Nadia is a pre-med student working on a project that evaluates the effect that changes in Toll-like receptors play in the expression and function of hepatic CYP3A during virus infection. She spent summer 2010 in a gene therapy lab at Stanford as an Amgen Scholar.

Project Title : Amplification of Genes that Regulate Expression of Hepatic CYP3A.

Project Title : Assessment of the Toxicity Associated with Novel Adenovirus-Based Vaccine Conjugates.

Undergraduate Research Scholar (Duke University)
**Gavin is a biology major at Duke who chose to work in the lab during the summer to explore a career in translational research. 

Project Title : Assessment of the Biodistribution of Biochemically Modified Adenovirus-Based Vaccine Candidates for Ebola.  

Project Title : Effect of Novel β-D-maltopyranosides to Preserve Adenovirus Structure and Infectivity during Actuation from Two Nasal Spray Delivery Devices and During Long-Term Storage at Several Temperatures.  

Project Title : Development of Novel Adenovirus Conjugates to Improve Oral Vaccine Potency.

Project Title : Assessment of the Long-Term Stability of Adenovirus-Based Vaccines at Ambient Temperatures.

Her project involves looking at phosphorylation patterns of the retinoid X receptor during viral infection in the liver.

MD/PhD Student

Project Title :In vitro and in vivo mechanistic assessment of Changes in CYP3A in the Intestine following Viral Infection.

Graduate Student (Molecular and Cellular Biology Program)
Co-advised with Adron Harris

Project Title :Systematic Knockdown of Genes Associated with Biochemical and Behavioral Aspects of Alcoholism using Novel Lentiviral Vectors.

Undergraduate Research Fellow, UT College of Natural Sciences

Project Title : Characterization of novel methods for the production of AAV.

Undergraduate Problems Course in Biochemistry

Project Title : Validation of a Bioassay to Assess the Potency of Adenovirus Vaccines.

Undergraduate Research Intern

**Elyor was accepted into the UT McNair Scholars Program which is geared to provide students with the resources and skills to successfully obtain admission to a graduate school of their choosing.  He was awarded a competitive fellowship to support his summer research.

Project Title :"Assessment of the HB227 Cell Line as a Suitable In Vitro Model for Mechanistic Study of Changes in Intestinal Cytochrome P450 expression and function During Viral Infection" based upon a proposal he constructed.

Pharmaceutics Graduate Student

Project Title :Characterization of the Immune Response after Oral Delivery of Novel Formulations of Recombinant Viruses.

Undergraduate Research Fellow, UT Clinical Laboratory Medicine Program

Project Title : Assessment of the Suitability of Nasal Delivery Devises for an Ebola Virus Vaccine.  

Project Title : Characterization of Formulations for Nasal Delivery of Vaccines.     

Project Title : Pharmacologic and Pharmacokinetic Studies of Docetaxel Alone and in Combination with Recombinant Adenovirus in Sprague Dawley Rats.     

Project Title : Development of Novel  Materials for Masking the Immune Response Against Therapeutic Proteins.    

Project Title : Assessment of residual poly(ethylene) glycol in PEGylated Adenovirus Preparations and Identification of Modified Viral Proteins using a Colorimetric Assay and Polyacrylamide gel Electrophoresis.  

Project Title : Characterization of Methods for Rapid Induction of Immunity to Biological Pathogens.  

Undergraduate Research Intern

**Erin was a biochemistry major at the California Institute of Technology.  She was awarded a competitive fellowship (SURF - Summer Undergraduate Research Fellowship) based upon a proposal she wrote to work in the lab and explore a career in translational research. 

Project Title : Assessment of Cytochrome P450 Gene Expression During Adenovirus Infection in Kidney Cell Lines.  

Pharmaceutics Graduate Student Degree awarded 8/10

Project Title : Pharmacokinetic Characterization of the Immune Response and Biodistribution of PEGylated Adenovirus in Non-Human Primates.

Undergraduate Research Fellow, UT College of Natural Sciences

Honors Thesis:  Characterization of T Cell Immunity Following Intranasal Immunization Against Ebola Virus.  

***Erin was accepted in the Cell Biology Graduate Program at Harvard University, Fall 2006.

Undergraduate Research Fellow, UT College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program

Undergraduate Research Fellow, UT College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program

Thesis Title:Mechanistic Studies of Adenovirus-Mediated Changes in Renal Cytochromes P450.

Thesis Title: Development and Validation of a Semi-Quantitative Reverse Transcription Polymerase Chain Reaction Assay to Detect Changes in Hepatic Cytochrome P450 Expression During Adenovirus Infection in the Rat.

**Kayla received the UT College of Pharmacy Basic Science Award in recognition of her research on adenovirus aggregation characteristics.

*** Shellie's dissertation was nominated by the College of Pharmacy for the UT Outstanding Dissertation Award.  Shellie currently holds a position in the Business Development group at CEDRA, Austin, TX and an adjunct faculty appointment in the Department of Biology at the University of Southern Indiana.

2000-01

Thesis Title: Overcoming extracellular barriers to drug delivery: molecular and nanoparticle interactions in mucus.