Pharmaceutics

Faculty

Photo

Croyle, Maria A., Ph.D.
Alan W. Hamm Centennial
Fellowship in Pharmacy
Professor of Pharmaceutics
PHR 4.214D
512-471-1972

macroyle@austin.utexas.edu


Publications

Croyle, M.A. 2009 Long-Term Virus-Induced Alterations of CYP3A-Mediated Drug Metabolism: A Look at the Virology, Immunology and Molecular Biology of a Multi-Faceted Problem Expert Opin Drug Metab Toxicol. (in press).

Renteria, S. S., Clemens, C.C., Wonganan, P.W., and Croyle, M. A. Effects of Concentration and Formulation on Adenovirus Stability and Infectious Titer During Actuation from Two Intranasal Delivery Devices 2009 (in review)

Wonganan, P., Clemmens, C., Leggiero, E., Brasky, K., Dekker, J., Astone, D., Pastore, L. and Croyle, M.A. Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus in Non-Human Primates. 2009 (in review).

Wonganan, P., Zamboni, W.C., Strychor, S., Dekker, J.D. and Croyle, M.A.  Drug-Virus Interaction: Effect of Administration of Recombinant Adenoviruses on the Pharmacokinetics of Docetaxel in a Rat Model.  2009 Cancer Gene Therapy 16(5):405-14.

Richardson, J.S., Yao, M.K., Tran, K.N., Croyle, M.A., Strong, J.E., Feldmann, H., and Kobinger, G.P. Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine. 2009 PLoS ONE. 4(4):e5308.

Croyle, M., Patel, A., Tran, K., Gray, M., Zhang, Y., Strong, J., Feldmann, H., and Kobinger, G.P. Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves The Immune Response In Mice. 2008 PLoS One. 3(10):e3548.

Callahan, S. M., Wonganan, P., and Croyle, M. A. Molecular and Macromolecular Alterations of Recombinant Adenoviral Vectors Do Not Resolve Changes in Hepatic Drug Metabolism During Infection. Viorlogy Journal  2008 Sept. 30 5:111   doi: 10.1186/1743-422X-5-111.

Boquet, M.P., Wonganan, P., Dekker, J.D., and Croyle, M.A. Impact of Route of Systemic Administration of Adenovirus on Virus-Mediated Toxicity: Focus on Mortality, Virus Distribution, and Drug Metabolism. J. Pharmacol. Toxicol. Methods . 2008 58(3):222-32.

Le, H. T., Boquet, M. P., Clark, E. A., Callahan, S. M., and Croyle, M. A. Renal Pathophysiology after Systemic Administration of Recombinant Adenovirus: Changes in Renal Cytochromes P450 Based upon Vector DoseHum. Gene Ther. 2006 17(11):1095-1111.

Callahan, S. M., Boquet, M. P., Ming, X., Brunner, L. J. and Croyle, M. A. Impact of Transgene Expression on Drug Metabolism Following Systemic Adenoviral Vector Administration. J. Gene Med. 2006 8(5):566-576.

Callahan, S. M., Ming, X., Lu, S. K., Brunner, L. J. and Croyle, M. A.  Considerations for Use of Recombinant Adenoviral Vectors: Dose Effect on Hepatic Cytochromes P450.  J. Pharmacol.  Exp. Ther. 2005 312(2):492-501.

Callahan, S. M., Wonganan, P., Obenauer-Kutner,  L. J., Sutjipto, S., Dekker, J.D., and Croyle, M. A. Controlled Inactivation of Recombinant Viruses with Vitamin B2  J. Virol. Meth. 2008 148(1-2):132-145.

Patel, A., Zhang, Y., Croyle, M., Gray, M., Strong, J., Feldmann, H., Wilson, J.M. and Kobinger, G.P. Mucosal Delivery of Adenovirus-Based Vaccine Protects Against Ebola Virus Infection. 2007 J. Infect. Dis. 196(Suppl. 2):S413-S420. 

Le, H. T., Yu, Q. C., Wilson, J. M. and Croyle, M. A. Utility of PEGylated Recombinant Adeno-Associated Viruses for Gene Transfer.  J. Control. Rel. 2005 108(1):161-177.

Croyle, M. A., Le, H., Linse, K., Ming, X., Toietta, G., Beaudet, A. and Pastore, L. PEGylated Helper-Dependent Adenoviral Vectors: Highly Efficient Vectors with an Enhanced Safety Profile. Gene Ther. 2005 12(7):579-588.

Croyle, M. A. Callahan, S. M., Auricchio, A., Schumer, G., Wilson, J. M., Linse, K., Brunner, L. J. and Kobinger, G. P. PEGylation of a Vesicular Stomatitis Virus G Pseudotyped Lentiviral Vector Prevents Inactivation in Serum. J. Virol.  2004 78(2):912-921.

Croyle, M. A. Callahan, S. M., Auricchio, A., Schumer, G., Wilson, J. M., Linse, K., Brunner, L. J. and Kobinger, G. P. PEGylation of a Vesicular Stomatitis Virus G Pseudotyped Lentiviral Vector Prevents Inactivation in Serum. J. Virol. 2003 78(2):912-921.

Quick, K. S. Gerding, K. and Croyle, M. A. Role of Container/Closure System and Formulation on Agitation-Induced Aggregation Phenomena in Recombinant Adenoviral Products BioProcessing 2003 2(5):35-41.

Cheng, X., Ming, X. and Croyle, M. A. PEGylated Adenoviruses Enhance Gene Delivery to the Intestinal Epithelium by the Oral Route. Pharm. Res. 2003 20(9):1444-1451.

Lehmberg, E., Shabram, P., Schluep, T., Wen, S.-F., Sugarman, B., Croyle, M., Koehl, M., Bonfils, E., Malarme, D., Sharpe, G., Nesbit, H., Borellini, F., Kamen, A., Hutchins, B. and Vellekamp, G. Adenovirus Reference Material - Determination of Particle Concentrations obtained by orthogonal, physical - chemical methods. BioProcessing 2003 2(3):50-56.

Adadevoh, K. Croyle, M. A., Malarme, D. Bonfils, E. and Bowe, M. A. A Short Term Field Use and Shipping Stability Study of a Wild Type Ad5 Adenoviral Reference Material. BioProcessing 2002 1(3):62-69.

Croyle, M. A.
, Chirmule, N., Zhang, Y. and James M. Wilson. PEGylation of E-1 Deleted Adenovirus Vectors Allows Significant Gene Expression upon Re-administration to Liver. Human Gene Therapy 2002 13(15):1887-1900.

Croyle, M.A., Cheng, X. and Wilson, J.M. Development of Formulations that Enhance the Physical Stability of Viral Vectors for Human Gene Therapy Gene Therapy 2001 8(17):1281-1291.

Croyle, M.A., Cheng, X., Sandhu, A. and Wilson, J.M. Development of Novel Formulations that Enhance Adenoviral-Mediated Gene Expression to the Lung In Vitro and In Vivo Molecular Therapy 2001 4(1):22-28.

Zhang, Y., Chirmule, N., Gao, G.P., Qian, R., Croyle, M., Joshi, B., Tazelaar, J., and Wilson, J.M. Acute Cytokine Response to Systemic Adenoviral Vectors is Mediated by Dendritic Cells and Macrophages Molecular Therapy (2001) 3(5):697-707.

Croyle, M. A., Chirmule, N., Zhang, Y. and James M. Wilson. "Stealth" Adenoviruses Blunt Cell Mediated and Humoral Immune Responses Against the Virus and Allow for Significant Gene Expression upon Re-administration for Gene Therapy to the Lung. J. Virol. (2001) 75(10):4792-4801.

Croyle, M. A., Yu, Q. C. and Wilson, J. M. Development of a Rapid Method for the PEGylation of Adenoviruses with Enhanced Transduction and Improved Stability Under Harsh Storage Conditions. Human Gene Therapy. (2000) 11:1721-1730.

Yu QC, Ma X, Croyle M, Qu G, Huang J, Gao GP, Hughes J, Wilson JM.  Electron microscopic evaluation of vector quality for gene therapy.  Microsc Microanal  (2000)  6:858-859

Croyle, M. A., Anderson, D. J., Roessler, B. J., and Amidon, G. L. Development of a Highly Efficient Purification Process for Recombinant Adenoviral Vectors for Oral Gene Delivery. Pharm. Dev. Technol. 3(3) (1998) 365-372.

Croyle, M. A., Roessler, B. J., Davidson, B. L., Hilfinger, J. M., and Amidon, G. L. Factors that Influence Stability of Recombinant Adenoviral Preparations for Human Gene Therapy Pharm. Dev. Technol. 3(3) (1998) 373-383.

Croyle, M.A., Roessler, B. J., Hsu, C-P., Sun, R. and Amidon, G. L. Beta Cyclodextrins Enhance Adenoviral-Mediated Gene Delivery to the Intestine. Pharm. Res. 15(9) (1998) 1348-1355.

Croyle, M.A., Stone, M., Amidon, G. L., and Roessler, B. J. In vitro and In vivo Assessment of Adenovirus 41 as a Vector for Gene Delivery to the Intestine Gene Therapy, 5 (1998) 645-654.

Croyle, M.A., Walter, E., Janich, S., Roessler, B. J., and Amidon, G. L.. Role of Integrin Expression in Adenovirus-Mediated Gene Delivery to the Intestinal Epithelium. Human Gene Therapy 9(4) (1998) 561-573.

Walter, E., Croyle, M. A., Davidson, B. L., Roessler, B. J., Hilfinger, J. M., Amidon, G. L. Adenovirus-mediated Gene Transfer to Intestinal Epithelial Cells as a Potential Approach for Oral Delivery of Peptides and Proteins. J. Control. Rel. 46 (1997) 75-87.

Walter, E., Croyle, M. A., Roessler, B. J., and Amidon, G. L. The Absence of Accessible Vitronectin Receptors in Differentiated Tissue Hinders Adenoviral-Mediated Gene Transfer to the Intestinal Epithelium In Vitro. Pharm. Res. 14(9) (1997) 1216-1222.

Invited Book Chapters

Kobinger, G.P., Croyle, M.A., and Feldmann, H.. Filoviruses.  In: Vaccines for Biodefense and Emerging and Neglected Diseases, Eds.  Barrett, A. D. T. and Stanberry, L. R. New York: Elsevier 2008  pp.323-336.

Croyle, M.A.  Gene Therapy.  In: Crommelin, D. Sindelar, E. and Meibohm B., Eds. Pharmaceutical Biotechnology: Fundamentals and Applications. 3rd Ed.  New York: Informa healthcare. 2008 pp:175-210.





More information about Dr. Croyle
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> Dr. Croyle's CV (pdf)
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Last Reviewed:March 31, 2014

Division Information

Mailing Address:
Pharmaceutics Division
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

Phone:
1-512-471-7182


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