Phone: (512) 471-1407
Office: PHR 4.214C
stavchansky@mail.utexas.edu
Generic and chemical class therapeutic substitution are changing the delivery
of medicines. If different products are therapeutically equivalent it makes sense
to allow the use of the cheaper alternative. Thus, the Food and Drug Administration
as wel l as the Pharmaceutical Industry are extremely interested in answering
the question of whether switching a patient from one drug product to another will
result in the same therapeutic efficacy and safety profile. The primary mission
of our laboratories i s to apply the principles of biopharmaceutics, pharmacokinetics,
and drug metabolism to evaluate and design drug delivery systems to ensure the
safety and efficacy of drug products. This involves the development of sensitive
and selective analytical meth odology to quantitatively measure the concentration
of drugs in biological systems and to better understand the relationship between
drug solubility and drug permeability through biological membranes. We have initiated
research in the pharmacokinetic eva luation and delivery of oligonucleotides.
Graduate students and research assistants acquire knowledge in the areas of physical
and analytical chemistry, statistics, data processing, computer assisted pharmacokinetics
and in the experimental design of clin ical protocols. Grants and contracts from
the government and the pharmaceutical industry provide our state-of-the-art laboratory
equipment.
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