Pharmaceutics

Faculty

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Williams III, Robert O. (Bill), Ph.D.
Division Head of Pharmaceutics
Johnson & Johnson
Centennial Chair in Pharmacy
Editor-in-chief, Drug Development &
Industrial Pharmacy
PHR 4.214B
512-471-4681
bill.williams@austin.utexas.edu


Research Interests

The research in my laboratory focuses on the formulation development, optimization, and delivery of small organic compounds, peptides, and proteins by a variety of technologies, including depot drug delivery, oral drug delivery and pulmonary/nasal drug delivery. In addition, other current research has focused on aerosol device technology, and novel analytical methods to quantitate and characterize these technologies. Analytical techniques including cascade impaction, HPLC, GC, X-ray diffraction, scanning electron microscopy, atomic force microscopy, Karl Fisher, laser light diffraction and TLC are routinely used to investigate raw materials and formulations. Significant effort is devoted to research to enhance drug solubility and dissolution through novel particle engineering technologies, including thin film freezing and precipitation processes.  

Below is a listing of some recently published papers from my laboratory that highlights my research interests.

  1.  W. Yang, K. P. Johnston and R. O. Williams III, Comparison of Bioavailability of Amorphous versus Crystalline Itraconazole Nanoparticles via Pulmonary Administration in Rats, European Journal of Pharmaceutics and Biopharmaceutics, 75(2010)33-41.

  2. W. Yang, K. T. Chow, B. Lang, N. P. Wiederhold, K. P. Johnston and R. O. Williams III, In Vitro Characterization and Pharmacokinetics in Mice Following Pulmonary Delivery of Itraconazole as Cyclodextrin Solubilized Solution, European Journal of Pharmaceutical Sciences, 39(2010)336-347.

  3. A. B. Watts, A. M. Cline, A. R. Saad, G. Hsiung, S. B. Johnson, J. I. Peters and R. O. Williams III, Characterization and Pharmacokinetic Analysis of Tacrolimus Dispersion for Nebulization in a Lung Transplanted Rodent Model, International Journal of Pharmaceutics 385(2010)46-52.

  4. J. M. Tam, J. D. Engstrom, D. Ferrer, R. O. Williams III and K. P. Johnston, Templated Open Flocs of Anisotropic Particles for Pulmonary Delivery with Pressurized Metered Dose Inhalers, Journal of Pharmaceutical Sciences, 99(2010)3150-3165.

  5. J. R. Hughey, J. C. DiNunzio, R. C. Bennett, C. Brough, D. A. Miller, H. Ma, R. O. Williams III and J. W. McGinity, Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing:  A Comparative Study of Hot Melt Extrusion and KinetiSol® Dispersing, AAPS PharmSciTech, 11(2010)760-774.

  6. K. P. O’Donnell and R. O. Williams III, Nanoparticle Systems for Oral Drug Delivery to the Colon, International Journal of Nanotechnology, 8(2011)4-20.  (invited)

  7. S. Bosselmann, D. E. Owens III, R. L. Kennedy, M. J. Herpin and R. O. Williams III, Novel Plasma Deposited Stability Enhancement Coating for Amorphous Ketoprofen, European Journal of Pharmaceutics and Biopharmaceutics, 78(2011)67-74.

  8. W. Yang, Donald E. Owens, Jay I. Peters and R. O. Williams III, Improved Bioavailability of Engineered Amorphous Nanostructured Compositions of Poorly Water-Soluble Drugs by Rapid Freezing Particle Engineering Technology, Drug Delivery Technologies, 11(2011)22-31.

  9. T. C. Carvalho, J. I. Peters and R. O. Williams III, Influence of Particle Size on Regional Lung Deposition – What Evidence is There? International Journal of Pharmaceutics, 406(2011)1-10. (invited)

  10. S. Bosselmann and R. O. Williams III, Has Nanotechnology Led to Improved Therapeutic Outcomes? Drug Development and Industrial Pharmacy, 38(2012)158-170.

  11. J. O. Morales, J. I. Peters and R. O. Williams III, Surfactants-Their Critical Role in Enhancing Drug Delivery to the Lungs, Therapeutic Delivery, 5(2011)623-641. (invited)

  12. K. P. O’Donnell and R. O. Williams III, Pulmonary Dispersion Formulations:  The Impact of Dispersed Powder Properties on Pressurized Metered Dose Inhaler Stability, Drug Development and Industrial Pharmacy, 39(2013)413-424.

  13. M. A. Miller, J. DiNunzio, M. E. Matteucci, B. S. Ludher, R. O. Williams III and K. P. Johnston, Flocculated Amorphous Itraconazole Nanoparticles for Enhanced in vitro Supersaturation and in vivo Bioavailability, Drug Development and Industrial Pharmacy, 38(2012)557-570.

  14. K. P. O’Donnell, Z. Cai, P. Schmerler and R. O. Williams III, Atmospheric Freeze Drying for the Reduction of Powder Electrostatics of Amorphous, Low Density, High Surface Area Pharmaceutical Powders, Drug Development and Industrial Pharmacy, 39(2013)205-217.

  15. M. Zhang, H. Li, B. Lang, K. P. O’Donnell, H. Zhang, Z. Wang, Y. Dong, C. Wu and R. O. Williams III, Formulation and Delivery of Improved Amorphous Fenofibrate Solid Dispersions Prepared by Thin Film Freezing, European Journal of Pharmaceutics and Biopharmaceutics, 82(2012)534-544.

  16.  S. Bosselmann, M. Nagao, K. T. Chow and R. O. Williams III, Influence of Formulation and Processing Variables on Properties of Itraconazole Nanoparticles Made by Advanced Evaporative Precipitation into Aqueous Solution, AAPS PharmSciTech, 13(2012)949-960.

  17. N. A. Beinborn, H. L. Lirola, R. O. Williams III, Effect of Process Variables on Morphology and Aerodynamic Properties of Voriconazole Formulations Produced by Thin Film Freezing, International Journal of Pharmaceutics, 429(2012):46-57.

  18. N. A. Beinborn, J. Du, N. P. Widerhold, H. D. C. Smyth and R. O. Williams III, Dry Powder Insufflation of Crystalline and Amorphous Voriconazole Formulations Produced by Thin Film Freezing to Mice, European Journal of Pharmaceutics and Biopharmaceutics, 81(2012)600-608.

  19. A. B. Watts, Y. Wang K. P. Johnston and R. O. Williams III, Respirable Low-Density Microparticles Formed In Situ from Aerosolized Brittle Matrices, Pharmaceutical Research, 30(2012)813-825.

  20. H. L. Dugas, J. I. Peters and R. O. Williams III, Nebulization of Mycophenolate Mofetil Inhalation Suspension:  Comparison with Oral and Pulmonary Administration of Cellcept®, International Journal of Pharmaceutics, 441(2013)19-29.

  21. D. A. Miller, J. C. DiNunzio, J. Hughey, R. O. Williams III and J. W. McGinity, KinetiSol:  A New Processing Paradigm for Amorphous Solid Dispersion Systems, Drug Delivery Technologies, 12(2012)1-10. (Invited)

  22. J. W. McGinity, R. O. Williams III, J. R. Hughey, J. C. DiNunzio and D. A. Miller, Kinetisol: A Novel Process for the Production of Pharmaceutical Solid Dispersion Systems, Bulletin Technique Gattefosse, No. 106(2012)68-78. (Invited)

  23. J. Leleux and R. O. Williams III, Recent Advances in Mechanical Reduction Methods:  Particulate Systems, Drug Development and Industrial Pharmacy, 2013 (in press).

  24. J. M. Keen, J. W. McGinity and R. O. Williams III, Enhancing Bioavailability Through Thermal Processing, International Journal of Pharmaceutics, 450(2013)185-196 (invited paper).

  25. C. Brough and R. O. Williams III, Amorphous Solid Dispersions and Nano-crystal Technologies for Poorly Water-soluble Drug Delivery, International Journal of Pharmaceutics, 2013 (in press) invited paper.

  26. J. Bayer, N. A. Das, C. E. Baisden, M. Rani, M. G. Schwacha, R. O. Williams III, J. I. Peters and S. B. Johnson, Effect of Inhaled Tacrolimus on Ischemia Reperfusion Injury in Rat Lung Transplant Model, The Journal of Thoracic and Cardiovascular Surgery, 2013 (in press).

  27. B. Lang, J. W. McGinity and R. O. Williams III, Hot-Melt Extrusion – Basic Principles and Pharmaceutical Applications, Drug Development and Industrial Pharmacy, June 2013 (in press).





More information about Dr. Williams
> Lab Group

Last Reviewed: June 20, 2013

Division Information

Mailing Address:
Pharmaceutics Division
College of Pharmacy
The University of Texas
at Austin
2409 University Ave.
Stop A1900
Austin, TX, USA
78712-1113

Email Address: pharmacy
@austin.utexas.edu

Phone:
1-512-471-7182


Researchers Offer Promise Through Enhanced Drug Delivery

Enhancing drug-delivery technologies can help in curing and treating diseases such as cancer, cardiovascular diseases, diabetes, fungal, respiratory and infectious diseases and treatment after organ transplants to prevent rejection.

> Read more about this story.


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