Summary & Research Interests
The research in our laboratories is concentrated on deriving information related to the clinical pharmacology of anticancer agents. To accomplish our research objectives, we establish suitable analytical (HPLC, CE, LC/MS) or molecular (PCR, Western, Elisa) methods for the measurement of the compounds in biological fluids or tissue. We explore the relationships between the pharmacokinetic parameters (clearance, AUC) of the agent and their biological targets, activity and/or toxicity. These correlations permit the development of rational dosing and scheduling regimens for the optimization of the compound's therapeutic index. We also evaluate genetic variations responsible for drug metabolism, transport or target affinity. The laboratories serve as the Pharmacology Core for the North American Brain Tumor Consortium (NABTC).
More information about Dr. Kuhn
> Selected Publications
Education & Research Ctr.
College of Pharmacy
The University of Texas
Health Science Center
7703 Floyd Curl Drive - MC 6220
San Antonio, TX
Email Address: pharmacy
Dr. Kelly Reveles, assistant professor of pharmacotherapy, is primary author of a study which found that the incidence of Clostridium difficile infection (CDI), a highly contagious gastrointestinal disease often linked to the overprescribing of antibiotics, nearly doubled between 2001 and 2010. It also determined there were no improvements in patient health outcomes, including mortality or hospital length of stay, over the study period.