Summary & Research Interests
The research in our laboratories is concentrated on deriving information related to the clinical pharmacology of anticancer agents. To accomplish our research objectives, we establish suitable analytical (HPLC, CE, LC/MS) or molecular (PCR, Western, Elisa) methods for the measurement of the compounds in biological fluids or tissue. We explore the relationships between the pharmacokinetic parameters (clearance, AUC) of the agent and their biological targets, activity and/or toxicity. These correlations permit the development of rational dosing and scheduling regimens for the optimization of the compound's therapeutic index. We also evaluate genetic variations responsible for drug metabolism, transport or target affinity. The laboratories serve as the Pharmacology Core for the North American Brain Tumor Consortium (NABTC).
More information about Dr. Kuhn
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Education & Research Ctr.
College of Pharmacy
The University of Texas
Health Science Center
7703 Floyd Curl Drive - MC 6220
San Antonio, TX
Email Address: pharmacy
Dr. Chris Frei has been appointed as division head for the college's Pharmacotherapy Division which is located on the UT Health Science Center San Antonio campus.