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Wiederhold, Nathan, Pharm.D.
Adjoint Associate Professorship of Pharmacotherapy
210- 567-8355
wiederholdn@uthscsa.edu


Abstracts


  1. Caudle, KE, Barker KS, Wiederhold NP, Rogers PD. Molecular Mechanisms of Increased Expression of CDR1, PDH1, and SNQ2 in Fluconazole Resistant Clinical Isolates of Candida glabrata. Platform Presentation at the American College of Clinical Pharmacy AnnualMeeting. Louisville, KY, October 18 – 22, 2008.


  2. Tolman JA, Wiederhold NP, McConville JT, Najvar LK, Graybill JR, Coalson JJ, Bocanegra R, Patterson TF, Williams RO III. Aerosolized Voriconazole as Prophylaxis Against Invasive Pulmonary Aspergillosis due to Aspergillus fumigatus. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  3. Wiederhold NP, Najvar LK, Kirkpatrick WR, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TF. Serum (1à3)-β-D-Glucan as a Measure of Disease Burden and Response to Caspofungin Therapy in Invasive Pulmonary Aspergillosis. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / InfectiousDisease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.*


  4. Wiederhold NP, Najvar LK, Bocanegra R, Molina D, Olivo M, Patterson TF, Graybill JR. In vivo Efficacy of Posaconazole Against Fusarium solani with Reduced In vitro Susceptibility. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  5. Thompson GR III, Najvar LK, Wiederhold NP, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TF. Development of a Murine Model of Cryptococcus gattii Meningitis. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  6. Thompson GR III, Vallor AC, Wiederhold NP, Fothergill AW, Wickes BL, Patterson TF. Serotype Differences in Antifungal Susceptibility Among Different Serotypes of Cryptococcus gattii and Cryptococcus neoformans. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  7. Najvar LK, Wiederhold NP, Kirkpatrick WR, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TF. Evaluation of a Non-Neutropenic Model of Invasive Pulmonary Aspergillosis Following Aerosolized Inoculation. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  8. Bosselmann S, Williams RO III, Wiederhold NP, Frei CR. Regional and Seasonal Variations in Invasive Aspergillosis in the United States Over the Last Decade. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  9. Nelson NA, Wiederhold NP, Williams RO III, Frei CR. Incidence and Clinical Relevance of Viral Co-Infection Among Patients with Invasive Aspergillosis in the United States. Poster Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy / Infectious Disease Society of America 46th Annual Meeting. Washington, DC, October 25 – 28, 2008.


  10. Tolman JA, Son Y, Wiederhold NP, McConville JT, Williams RO III. Aerosol Characterization and Single-Dose Pharmacokinetic Analysis of Nebulized Voriconazole Solution (AM-08-01684). Poster Presentation at the 2008 American Association of Pharmaceutical Scientists Annual Meeting. Atlanta, GA, November 16 0 20, 2008.


  11. Tolman JA, Nelson NA, Bosselmann S, Wiederhold NP, Williams RO III. Pharmacokinetic Profile Following Multiple Doses of Inhaled Voriconazole Solution in Mice (AM-08-01663). Poster Presentation at the 2008 American Association of Pharmaceutical Scientists Annual Meeting. Atlanta, GA, November 16 0 20, 2008.


  12. Patterson TF, Filler SG, Denning DW, Sheppard DC, Wiederhold NP, Wickes BL, Warn PA, Najvar LK, Vallor AC, Kirkpatrick WR, Graybill JR. Utility of Standardized Animal Models for the Diagnosis of Invasive Aspergillosis (Abstract 064). Accepted for presentation at the 3rd Advances Against Aspergillosis Meeting. Miami, FL, January 16 – 19, 2008.


  13. Wiederhold NP, Vallor AC, Najvar LK, Kirkpatrick WR, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TF. Serum (1à3)-β-D-Glucan as a Measure of Treatment Outcome in Invasive Pulmonary Aspergillosis (Abstract 026). Accepted for presentation at the 3rd Advances Against Aspergillosis Meeting. Miami, FL, January 16 – 19, 2008.


  14. Frei CR, B.W. Wickes BL, Burgess DS, Wiederhold NP, Lewis JS, Carden MF, Zamarripa DE, Yu Y, Jorgensen JH. Genotype-specific clinical outcomes among patients infected with extended-spectrum beta-lactamase producing bacteria. Poster Presentation at the American College of Clinical Pharmacy Annual Meeting. Denver, CO. October 14 – 17, 2007.


  15. Lewis JS, Grabinski JL, Lee SA, Patterson TF, Wiederhold NP. Echinocandin Potency in the Presence of Sera and Potential Impact in the Treatment of Candida krusei Invasive Candidiasis (IC). Poster Presentation at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (abstr. M-557). Chicago, IL. September 17 – 20, 2007.


  16. Cota J, Grabinski JL, Rogers PD, Edlind TD, Wiederhold NP. Association between the cell wall integrity (CWI) pathway and chitin content in the attenuation of caspofungin (CAS) activity in Candida glabrata. Platform Presentation at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (abstr. M-745). Chicago, IL. September 17 – 20, 2007.


  17. Wiederhold NP, Vallor AC, Najvar LK, Kirkpatrick WR, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TF. Assessment of Serum Beta-1,3-Glucan (BG) as a Measure of Disease Burden in Invasive Pulmonary Aspergillosis (IPA). Platform Presentation at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (abstr. M-746).Chicago, IL. September 17 – 20, 2007.


  18. Najvar LK, Wiederhold NP, Bocanegra R, Olivo M, Molina D, Kirkpatrick WR, Patterson TF, Graybill JR. Assessment of Survival and Treatment Response in 2 In Vivo Models of Invasive Aspergillosis (IA): Intravenous (IV) and Aerosol Challenge. Poster Presentation at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (abstr. M-). Chicago, IL.
    September 17 – 20, 2007.


  19. Lee SA, Grabinski JL, Garcia-Effron G, Perlin DS, Wiederhold NP. Utility of Pyrosequencing to Detect FKS1 Mutations that Confer Reduced Echinocandin Susceptibility (RES) in Candida albicans . Poster Presentation at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (abstr. M-531). Chicago, IL. September 17 – 20, 2007.


  20. Boyd N. Wiederhold NP, Carden MF, Burgess DS. Assessment of Meropenem and Amikacin Activity against Acinetobactere baumanni in an in vitro Pharmacodynamic Model (abstr. 142). Platform Presentation at the American College of Clinical Pharmacy Annual Meeting. St. Louis, MO. October 26 – 29th, 2006.


  21. Cota JM, Frei CR, Burgess DS, Lopez-Ribot JL, Wiederhold NP. Cell-Wall Integrity Pathway Mediated Response of Candida glabrata to Caspofungin Challenge (abstr. 414). Poster Presentation at the American College of Clinical Pharmacy Annual Meeting. St. Louis, MO. October 26 – 29th, 2006.


  22. Alvarez CA, Grabinski JL, Talbert RL, Wiederhold NP. Molecular Characterizatio of Aspergillus fumigatus Isolates with elevated Itraconazole, Voriconazole, and Posaconazole Minimum Inhibitory Concentrations (abstr. 124). Poster Presentation at the American College of Clinical Pharmacy Annual Meeting. St. Louis, MO. October 26 – 29th, 2006.


  23. Frei CR, Wiederhold NP, Burgess DS. Alternative Antimicrobials for Methicillin-resistant Staphylococcus aureus (abstr 129). Platform Presentation at the American College of Clinical Pharmacy Annual Meeting. St. Louis, MO. October 26 – 29th, 2006.


  24. Frei CR, Wiederhold NP, Burgess DS. Discrepancies in International Susceptibility Criteria for the Carbapenems vs. Gram-Negative Aerobes and the role of Pharmacokinetic-Pharmacodynamic Modeling with Monte Carlo Simulation (abstr 131E). Poster Presentation
    at the American College of Clinical Pharmacy Annual Meeting. St. Louis, MO. October 26 –29th, 2006.


  25. Alvarez CA, Wiederhold NP, McConville JT, Peters JI, Najvar LK, Graybill JR, Marks D, Talbert RL, Burgess DS, Bocanegra R, Johnston KP, Williams, RO III. Aerosolized Itraconazole as Prophylaxis against Invasive Pulmonary Aspergillosis due to Aspergillus fumigatus (abstr. M-1688). Platform Presentation at the 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27 – 30, 2006.


  26. Wiederhold NP, Wickes BL, Patterson TF. Increase Gene Expression of Mitogen-Activated Protein Kinase A is Associated with Attenuated Caspofungin Activity in Aspergillus fumigatus (abstr. M-0364). Platform Presentation at the 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27 – 30, 2006.


  27. Wiederhold NP, Talbert RL. Pharmacodynamics of Itraconazole and Voriconazole in Combination with Trichostatin A against Aspergillus fumigatus (abstr. M-1572). Poster Presentation at the 46th Interscience Conference on Antimicrobial Agents and Chemotherapy.San Francisco, CA. September 27 – 30, 2006.


  28. Carden M, Boyd N, Wiederhold NP, Burgess DS. In Vitro Synergy of 5 Beta-Lactams in Combination with Amikacin, Colistin, Levofloxacin, and Doxycycline against Acinetobacter baumannii (abstr. E-1363). Poster Presentation at the 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27 – 30, 2006.

  29. Najvar LK, Bocanegra R, Vallor A, Olivo M, Molina N, Wiederhold N, Graybill JR. Anidulafungin vs. Caspofungin: Does MIC Predict In Vivo Response (abstr. P-0110)? Poster Presentation at the 2006 International Society of Human and Animal Mycology, Paris, France, June 25th – 29th, 2006.


  30. Peters J, Vaughn J, Wiederhold N, Coalson J, McConville JT, Burgess D, Talbert RL, Johnston KP, Williams RO. Murine Airway Histology and Alveolar Macrophage Uptake of Inhaled Amorphous Itraconazole (abstr. A64). Poster Presentation at the International Conference of the American Thoracic Society. San Diego, CA. May 19 – 24, 2006.


  31. McConville JT, Vaughn JM, Burgess DS, Talbert RL, Wiederhold NP, Peters JI, Johnston KP, Williams RO. Single Dose Variability and Multi-Dose Studies of Nebulized Itraconazole in a Murine Model. Poster Presentation at the Respiratory Drug Delivery X Conference. Boca Raton, FL. April 23 – 27, 2006.


  32. Wiederhold NP, Graybill JR, Najvar LK, Burgess DS. In Vitro Pharmacodynamics of Anidulafungin and Caspofungin Against Isolates of Candida glabrata with Elevated MICs to Caspofungin (abstr. M-2160). Poster Presentation at the 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. December 16 – 19, 2005.


  33. Wiederhold NP, Frei CR, Burgess DS. Attenuated Activity of Amphotericin B, Itraconazole, and Voriconazole against Aspergillus fumigatus Hyphae (abstr. M-2161). Poster Presentation at the 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. December 16 – 19, 2005.


  34. Hoeben BJ, Burgess DS, Najvar LK, Talbert RL, McConville JT, Peters JI, Bocanegra R, Graybill JR, Jones BL, Wiederhold NP, Williams RO. In vivo Efficacy of Aerosolized Nanostructured Itraconazole Formulations for the Prevention of Invasive Pulmonary Aspergillosis (abstr. M-1005). Poster Presentation at the 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. December 16 – 19, 2005.


  35. Liu TT, Earhart KD, Homayouni R, Patterson TF, Villarreal NC, Wiederhold NP, Burgess DS, Rogers PD. Genome-wide Expression Profile Analysis Reveals Genes Differentially Expressed in Association with Azole and Echinocandin Cross Resistance in a Clinical Isolate of Candida glabrata (abstr. M-2157). Poster Presentation at the 45th Annual Interscience mConference on Antimicrobial Agents and Chemotherapy. Washington, DC. December 16 – 19, 2005.


  36. Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Eagle-like Effect of Caspofungin against Candida and Aspergillus spp.: Association with Homeostatic Mechanisms of Cell Wall Integrity (abstr M-1682). Platform presentation at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 30 – November 2, 2004.


  37. Wiederhold NP, Kontoyiannis DP, Tam VH, Chi J, Prince RA, Lewis RE. Relationship between Interferon-Gamma (IFN-γ) / Interleukin-10 (IL10) and Mycological Efficacy of Amphotericin B Deoxycholate in Invasive Pulmonary Aspergillosis (abstr. M-230). Poster Presentation at the 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 30 – November 2, 2004.


  38. Lewis RE, Wiederhold NP, Lionakis MS, Chi J, Prince RA, Kontoyiannis DP. Frequency and Distribution of Gliotoxin Producing Aspergillus Isolates Recovered from Patients at a Tertiary Care Cancer Center (abstr. M-245). Poster presentation at the 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 30 – November 2, 2004.


  39. Tam VH, Schilling AN, Kwa AL, Wiederhold NP, Lewis RE. Pharmacodynamics of Polymixin B Against Multi-drug Resistant Pseudomonas aeruginosa (abstr. A-1871). Poster presentation at the 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 30 – November 2, 2004.


  40. Lionakis MS, Halter G, Lewis RE, Wiederhold NP, Kontoyiannis DP. Efficacy of Voriconazole in Experimental Aspergillosis in Drosophila (abstr. ). Platform presentation at the 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 30 – November 2, 2004.


  41. Lionakis MS, Halder G, Lewis RE, Wiederhold NP, May GS, Kontoyiannis DP. Experimental Aspergillosis in Drosophila: Influence of Mode of Infection on Aspergillus Virulence (abstr. ).
    Poster presentation at the 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. October 30 – November 2, 2004.


  42. Wiederhold NP, Lewis RE, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA. Detection of Gliotoxin, an Immunosuppressive Metabolite Produced by Aspergillus fumigatus, In Experimental and Human Aspergillosis. Presented at the 7th Annual Conference on Infectious Diseases. Phoenix, AZ. May 2004.


  43. Wiederhold N, Chi J, Kontoyiannis D, Prince R, Lewis R. In Vitro Reduction of the Aspergillus fumigatus Metabolite Gliotoxin by Amphotericin B Deoxycholate, Caspofungin, and Voriconazole (abstr. M1243). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  44. Wiederhold N, Kontoyiannis D, Chi J, Prince R, Tam V, Lewis R. In Vivo Pharmacodynamics of Caspofungin in a Murine Model of Invasive Pulmonary Aspergillosis (abstr. M-476). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  45. Wiederhold N, Coyle E, Chi J, Raad I, Prince R, Lewis R. Antibacterial Activity of Linezolid and Vancomycin in an In Vitro Pharmacodynamic Model of Gram-Positive Catheter-Related Bloodstream Infections (abstr. A-1163). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  46. Lewis R, Chi J, Wiederhold N, Kontoyiannis D, Han X, Prince R. Detection of Gliotoxin, an Immunologically-Active Metabolite Secreted by Aspergillus fumigatus, in Animals and Humans with Invasive Aspergillosis (abstr. M-1015). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  47. Wiederhold N, Kontoyiannis D, Lewis R. In Vitro Pharmacodynamics of Rapid vs. Continuous Infusion Amphotericin B Deoxycholate in the Presence of Human Serum Albumin (abstr. M-1259). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  48. Lewis R, Wiederhold N, Klepser M. In Vitro Pharmacodynamics of Amphotericin B, Itraconazole, and Voriconazole Against Aspergillus, Fusarium, and Scedosporium spp (abstr. M1255). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  49. Wiederhold N, Chi J, Prince R, Kontoyiannis D, Lewis R. Immunopharmacology of Amphotericin B Deoxycholate in Acute Invasive Pulmonary Aspergillosis. Presented at the Society of Infectious Diseases Pharmacists Annual Meeting. Chicago, IL. September 13, 2003.


  50. Rogers P, Crisp S, Barker K, Wiederhold N, Lewis R. Genome-Wide Expression of Experimentally Induced Amphotericin B Resistance in Candida albicans (abstr. M-400). Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 14-17, 2003.


  51. Chi J, Lewis R, Wiederhold N, Prince R. Simple Determination of Caspofungin in Mouse Plasma by High-Performance Liquid Chromatography with Fluorescence Detection. Presented at the 14th International Symposium on Pharmaceutical and Biomedical Analysis. Kissimmee, FL. September 14-17, 2003.


  52. Chi J, Lewis R, Wiederhold N, Prince R. Simple Determination of Gliotoxin in Mouse Lung Tissue by High-Performance Liquid Chromatography with UV Detection. Presented at the 14th International Symposium on Pharmaceutical and Biomedical Analysis. Kissimmee, FL. September 14-17, 2003.


  53. Chi J, Lewis R, Wiederhold N, Prince R. Simple Determination of Voriconazole in Mouse Lung Tissue by High-Performance Liquid Chromatography with UV Detection. Presented at the 14th International Symposium on Pharmaceutical and Biomedical Analysis. Kissimmee, FL. September 14-17, 2003.


  54. Lubelchek R, Gabler C, Wiederhold N, Cacciabando J, Highstein G, Mundy L. Mock Antiretroviral Therapy Trials as an Assessment Tool for Adherence: Correlates with subsequent HIV Suppression (abstr. 542-T). Presented at the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, WA. February 24 – 28, 2002.


  55. Wiederhold NP, Ritchie DJ. Review of Oral Ciprofloxacin Use Before And After Removal from Antibiotic Restriction. Abstracts of the American Society of Health System Pharmacists – Midyear Clinical Meeting, Las Vegas, Nevada. December 2000.

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Last Reviewed: October 18, 2010

Division Information

Mailing Address:
Pharmacotherapy
Education & Research Ctr.
College of Pharmacy
The University of Texas
Health Science Center
7703 Floyd Curl Drive - MC 6220
San Antonio, TX
78229-3900
USA

Email Address: pharmacy
@austin.utexas.edu

Phone:
1-210-567-8355


Frei to Lead Division

Dr. Chris Frei has been appointed as division head for the college's Pharmacotherapy Division which is located on the UT Health Science Center San Antonio campus.

Read more about Frei's appointment

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