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Wiederhold, Nathan, Pharm.D.
Adjoint Associate Professorship of Pharmacotherapy
210- 567-8355
wiederholdn@uthscsa.edu


Publications

Original Research
  1. Wiederhold NP, Grabinski JL, Garcia-Effron G, Perlin DS, Lee SA. Pyrosequencing to Detect Mutations in FKS1 that Confer Reduced Echinocandini Susceptibility in Candida albicans. Antimicrobial Agents and Chemotherapy 2008 (In Press).

  2. Thompson GR, Wiederhold NP, Vallor AC, Villareal NC, Lewis JS II, Patterson TF. Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata. Antimicrobial Agents and Chemotherapy 2008 (In Press).

  3. Brzankalski GE, Najvar LK, Wiederhold NP, Bocanegra R, Fothergill AW, Rinaldi MG, Patterson TF, Graybill JR. Evaluation of Aminocandin and Caspofungin against Candida glabrata Including Isolates with Reduced Caspofungin Susceptibility. Journal of Antimicrobial Chemotherapy 2008 (In Press).

  4. Thompson GR III, Fothergill AW, Wiederhold NP, Vallor AC, Wickes BL, Patterson TF. Evaluation of Etest Method for Determining Isavuconazole MICs Against Cryptococcus gattii and Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy 2008 (In Press).

  5. Najvar LK, Bocanegra R, Wiederhold NP, Lambros C, Najarian N, Patterson TF, Graybill JR. Therapeutic and Prophylactic Efficacy of Aminocandin (IP960) Against Disseminated Candidiasis in Mice. Clinical Microbiology and Infection 2008 (In press).

  6. Frei CR, Wiederhold NP, Burgess DS. Antimicrobial Breakpoints for Gram-Negative Aerobic Bacteria Based on Pharmacokinetic-Pharmacodynamic Models with Monte Carlo Simulation. Journal of Antimicrobial Chemotherapy 2008 (In press).

  7. Wiederhold NP, Najvar LK, Vallor AC, Kirkpatrick WR, Bocanegra R, Molina D, Olivo M, Graybill JR, Patterson TP. Assessment of Serum (1à3)-b-D-Glucan as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis.  Antimicrobial Agents and Chemotherapy 2008; 52: 1176 - 1178.

  8. Cota JM, Grabinski JL, Talbert RL, Burgess DS, Rogers PD, Edlind TD, Wiederhold NP. Increases in SLT2 Expression and Chitin Content are Associated with Incomplete Killing of Candida glabrata by Caspofungin. Antimicrobial Agents and Chemotherapy 2008; 52: 1144 - 1146.
    .***Selected for Faculty 1000 Biology Evaluation**

  9. Wiederhold NP, Najvar LK, Bocanegra R, Molina D, Olivo M, Graybill JR. In vivo Efficacy of Anidulafungin and Caspofungin Against Candida glabrata and Association with In vitro Potency in the Presence of Sera. Antimicrobial Agents and Chemotherapy 2007; 51: 1616-20.

  10. Vaughn JM, Wiederhold NP, McConville JT, Coalson JJ, Talbert RL, Burgess DS, Johnston KP, Williams RO, Peters JI. Murine Airway Histology and Intracellular Uptake of Inhaled Amorphous Itraconazole. Accepted for publication, International Journal of Pharmaceutics, 2007.

  11. Alvarez CA, Wiederhold NP, McConville JT, Peters JI, Najvar LK, Graybill JR, Marks D, Talbert RL, Burgess DS, Bocanegra R, Johnston KP, Williams, RO III. Aerosolized Nanostructured Itraconazole as Prophylaxis against Invasive Pulmonary Aspergillosis. Accepted for publication, Journal of Infection, 2007.

  12. Cota J, Carden M, Graybill JR, Najvar LK, Burgess DS, Wiederhold NP. In vitro Pharmacodynamics of Anidulafungin and Caspofungin against Candida glabrata Including Strains with Decreased Caspofungin Activity. Antimicrobial Agents and Chemotherapy 2006; 50: 3926-28.

  13. Hoeben BJ, Burgess DS, McConville JT, Najvar LK, Talbert RL, Peters JI, Wiederhold NP, Frei BL, Graybill JR, Bocanegra R, Overhoff KA, Sinswat P, Johnston KP, Williams RO. In vivo Efficacy of Aerosolized Nanostructured Itraconazole Formulations for the Prevention of Invasive Pulmonary Aspergillosis. Antimicrobial Agents and Chemotherapy 2006; 50: 1552-54.

  14. Wiederhold NP, Tam VH, Chi J, Prince Ra, Kontoyiannis DP, Lewis RE. Pharmacodynamic Activity of Amphotericin B Deoxycholate is Associated with Peak Plasma Concentrations in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis. Antimicrobial Agents and Chemotherapy 2006; 50: 469-73.

  15. Dennis CG, Greco WR, Brun Y, Youn R, Slocum HK, Bernacki RJ, Lewis R, Wiederhold N, Holland SM, Petraitiene R, Walsh TJ, Segal BH. Effect of Amphotericin B and Micafungin Combination on Survival, Histopathology, and Fungal Burden in Experimental Aspergillosis in the p47phox-/- Mouse Model of Chronic Granulomatous Disease. Antimicrobial Agents and Chemotherapy 2006; 50: 422-27.

  16. Lewis RE, Wiederhold NP, Prince RA, Kontoyiannis DP. In vitro Pharmacodynamics of Rapid Versus Continuous Infusion of Amphotericin B Deoxycholate Against Candida species in the Presence of Human Serum Albumin. Journal of Antimicrobial Chemotherapy 2006; 57: 288-93.

  17. Lionakis MS, Chamilos G, Lewis RE, Wiederhold NP, Raad II, Samonis G, Kontoyiannis DP. Pentamidine is Active in a Neutropenic Murine Model of Acute Invasive Pulmonary Fusariosis. Antimicrobial Agents and Chemotherapy 2006; 50: 294-7.

  18. Lewis RE, Wiederhold NP, Lionakis MS, Prince RA, Kontoyiannis DP. Frequency and Species Distribution of Gliotoxin-Producing Aspergillus Isolates Recovered from Patients at a Tertiary-Care Cancer Center. Journal of Clinical Microbiology 2005; 43: 6120-22.

  19. Wiederhold NP, Kontoyiannis DK, Prince RA, Lewis RE. Attenuation of Caspofungin Activity at High Concentrations Against Candida albicans: Possible Role of Cell Wall Integrity and Calcineurin Pathways. Antimicrobial Agents and Chemotherapy 2005; 49: 5146-48.

  20. Tam VH, Schilling AN, Vo G, Kabbara S, Kwa AL, Wiederhold NP, Lewis RE. Pharmacodynamics of Polymyxin B against Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 2005; 49: 3624-30.

  21. Wiederhold NP, Coyle EA, Raad II, Prince RA, Lewis RE. Antibacterial Activity of Linezolid and Vancomycin in an In Vitro Pharmacodynamic Model of Gram-Positive Catheter-Related Bacteraemia. Journal of Antimicrobial Chemotherapy 2005; 792-5.

  22. Lewis RE, Wiederhold NP, Klepser ME. In vitro Pharmacodynamics of Amphotericin B, Itraconazole and Voriconazole Against Aspergillus, Fusarium, and Scedosporium spp. Antimicrobial Agents and Chemotherapy 2005; 49: 945-5.

  23. Lionakis MS, Lewis RE, May GS, Wiederhold NP, Albert ND, Halder G, Kontoyiannis DK. Toll-deficient Fruit Flies as a Fast, High-Throughput Model to Study the Efficacy of Antifungal Drugs and Virulence in Aspergillosis. Journal of Infectious Diseases 2005; 191: 1188-95.

  24. Lewis RE, Wiederhold NP, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA. Detection of Gliotoxin, a Mycotoxin Produced by Aspergillus fumigatus, in Experimental and Human Aspergillosis. Infection and Immunity 2005; 73: 635-37.

  25. Wiederhold NP, Kontoyiannis DP, Chi J, Prince RA, Tam VH, Lewis RE. Pharmacodynamics of Caspofungin in a Murine Model of Invasive Pulmonary Aspergillosis: Evidence of Concentration-Dependent Activity. Journal of Infectious Diseases 2004; 190: 1464-71.

  26. Barker KS, Crisp S, Wiederhold NP, Lewis RE, Rogers PD. Genome Wide Expression Profiling Reveals Genes Associated with Amphotericin B and Fluconazole Resistance in Experimentally Induced Antifungal Resistant Isolates of Candida albicans. Journal of Antimicrobial Chemotherapy 2004; 54: 376-85.

  27. Hoffman BR, Delasalas H, Blanca K, Wiederhold N, Lewis RE, Williams L. Screening of Antibacterial and Antifungal Activities of Ten Medicinal Plants from Ghana. Pharmaceutical Biology 2004; 42: 13-17.

  28. Liu W, Lionakis MS, Lewis RE, Wiederhold NP, May GS, Kontoyiannis DP. Attentuation of Itraconazole Fungicidal Activity following Preexposure of Aspergillus fumigatus to Fluconazole. Antimicrobial Agents and Chemotherapy 2003; 47: 3592-97.

Review Articles
  1. Yang W, Wiederhold NP, Williams RO III. Drug Delivery Strategies for Improved Azole Antifungal Action. Expert Opinion on Drug Delivery 2008 (In Press).

  2. Wiederhold NP. Paradoxical Echinocandin Activity: A Limited In Vitro Phenomenon? Medical Mycology 2008 (In Press).

  3. Wiederhold NP. Attenuation of Echinocandin Activity at Elevated Concentrations: A Review of the Paradoxical Effect. Current Opinion in Infectious Diseases 2007; 20: 574-578.

  4. McConville JT, Wiederhold NP. Effective Inhalation Treatment for Acute Fungal Infections. Inhalation 2007; 1: 1: 6 – 9. (www.inhalationmag.com)

  5. Wiederhold NP, Lewis JS. The Echinocandin Micafungin: A Review of the Pharmacology, Spectrum of Activity, Clinical Efficacy and Safety. Expert Opinion on Pharmacotherapy 2007; 8(8): 1155-1165.

  6. Wiederhold NP, Lewis RE, Kontoyiannis DP. Invasive Aspergillosis in Patients with Hematological Malignancies. Pharmacotherapy, 2003; 23(12): 1592-1610.

  7. Wiederhold NP, Lewis RE. The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacy. Expert Opinion on Investigational Drugs 2003; 12 (8): 1313-1333.

  8. Wiederhold NP, Ritchie DJ. Moxifloxacin: A Review of its In Vitro Activity, Clinical Efficacy, and Adverse Effects. Journal of Infectious Diseases Pharmacotherapy 2003; 6(1):1-26.

Book Chapters

  1. Wiederhold NP, Patterson TF. Antifungal therapy (Chapter 204). In: Current Therapy of Infectious Diseases. 3rd edition. Schlossberg D, ed. Cambridge University Press.

  2. J.T. McConville, N.P. Wiederhold. Invasive pulmonary aspergillosis: therapeutic and prophylactic strategies. In: Advanced formulation design to optimize therapeutic outcomes. Ed. J.T. McConville, D.R. Taft, R.O. Williams III. Informa Healthcare USA.

  3. Ritchie DJ, Wiederhold NP. Antimicrobial Agents. Washington Manual Infectious Diseases Subspecialty Consult. Lippincott Williams & Wilkins. Starlin R, Ed.

  4. Ritchie DJ, Wiederhold NP. Infectious Diseases Cases – Viral Infections. ASHP’s PharmPrep 2nd Ed. ASHP. Diane Ginsburg, Ed.

  5. Lewis RE, Wiederhold NP. Murine Model of Invasive Aspergillosis. Submitted to Antifungal Agents: Methods and Protocols. Humana Press Inc. Ernst EJ, Rogers PD, eds.

Case Reports/Letters

  1. Lewis RE, Wiederhold NP. The Solubility Ceiling: A Rationale for Continuous Infusion Amphotericin B Therapy? (Letter) Clinical Infectious Diseases 2003; 37 (6): 871-872.

  2. Barnes BJ, Wiederhold NP, Micek ST, Polish LB, Ritchie DJ. Enterobacter cloacae Ventriculitis Successfully Treated with Cefepime and Gentamicin: Case Report and Review of the Literature. Pharmacotherapy 2003; 23(3): 537-542.


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Last Reviewed: October 18, 2010

Division Information

Mailing Address:
Pharmacotherapy
Education & Research Ctr.
College of Pharmacy
The University of Texas
Health Science Center
7703 Floyd Curl Drive - MC 6220
San Antonio, TX
78229-3900
USA

Email Address: pharmacy
@austin.utexas.edu

Phone:
1-210-567-8355


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