Recent Publications
Lewis, J., Burstein, E., Birkey-Reffey, S., Bratton,
S. B., Roberts, A. B. and Duckett,
C. S. (2004) Uncoupling of the signaling and
caspase-inhibitory properties of XIAP.
J.
Biol. Chem. 279, 9023-9029.
Bratton, S. B. and Cohen, G. M. (2003) Death receptors leave a
caspase footprint that 'Smacs' of XIAP.
Cell
Death Differ. 10, 4-6.
Bratton, S. B., Lewis, J., Butterworth, M., Duckett, C. S., and
Cohen, G. M. (2002) XIAP inhibition of caspase-3 preserves its association with
the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell
Death Differ. 9, 881-892.
MacFarlane, M., Merrison, W., Bratton,
S. B., and Cohen, G. M. (2002) Proteasome-mediated
degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in
vitro. J.
Biol. Chem. 277, 36611-36616.
Bratton, S. B., Sun, X-M., Butterworth, M., MacFarlane, M., and Cohen, G. M. (2002) Bcl-2 and Bcl-xL
inhibit CD95-mediated apoptosis by preventing mitochondrial release of
Smac/DIABLO and subsequent inactivation of XIAP. J.
Biol. Chem. 277, 11345-11351.
Bratton, S. B. and Cohen, G. M. (2002) Caspase cascades in
chemically-induced apoptosis.
In: Biological Reactive
Intermediates VI (Dansette, et al.,
eds.), Klewer Academic/Plenum Press, pgs. 407-420.
Cain, K., Bratton, S. B. and Cohen, G. M. (2002) The Apaf-1 apoptosome: a
large caspase-activating complex. Biochimie 84, 203-214.
Bratton, S. B., Walker, G., Srinivasula, S. M., Sun, X-M.,
Butterworth, M., Alnemri, E. S. and Cohen, G.M. (2001) Recruitment, activation
and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP
complexes. EMBO
J. 20, 998-1009.
Bratton, S. B., Walker, G., Cain, K., and Cohen, G. M. (2001)
Caspase-3 cleaves Apaf-1 into an ~30 kDa fragment that associates with an
inappropriately oligomerized and biologically inactive ~1.4 MDa apoptosome
complex. Cell
Death Differ. 8, 425-433.
Bratton, S. B. and Cohen, G. M. (2001) Apoptotic death sensor: an organelle1s alter ego. Trends
Pharmacol. Sci. 22, 306-315.
Cain, K., Bratton, S. B., Langlais, C., Walker, G., Brown, D. G., Sun, X-M.
and Cohen, G. M. (2000) Apaf-1 oligomerizes into biologically active ~700-kDa
and inactive ~1.4- MDa apoptosome complexes. J.
Biol. Chem. 275, 6067-6070.
Bratton, S. B., MacFarlane, M., Cain, K. and Cohen, G. M. (2000)
Protein complexes activate distinct caspase cascades in death receptor and
stress induced apoptosis. Exp.
Cell Res., 256, 27-33.
Bratton, S. B., Lau, S. S., and Monks, T. J. (2000) The putative
benzene metabolite 2,3,5-tris-(glutathion-S-yl)hydroquinone depletes glutathione, stimulates
sphingomyelin turnover, and induces apoptosis in HL-60 cells. Chem.
Res. Toxicol. 13, 550-556.
Bratton, S. B., Lau, S. S., and Monks, T. J. (1997) Identification of quinol-thioethers in bone marrow of hydroquinone/phenol-treated rats and mice, and their potential role in benzene-mediated hematotoxicity. Chem. Res. Toxicol. 10, 859-865.
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July 6, 2005 Faculty Directory College of Pharmacy at UT Austin Comments to: pharmacy@www.utexas.edu |
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