Youngeun Choi, Ph.D.
As a grad student in the Bratton Lab, my project focused primarily on understanding how two related inhibitor of apoptosis proteins, cIAP1 and cIAP2, suppressed apoptosis through their distinct interactions with the effector caspases- 3 and -7.
Madhavi Malladi, Ph.D.
Caspases are activated in response to various cell death stimuli and inhibitor of apoptosis (IAP) proteins can bind and inhibit caspases. My research was primarily focused on understanding the mechanisms by which IAPs and their antagonists regulate caspase activation using Drosophila a model system.
Srinivas Malladi, Ph.D.
During stress-induced apoptosis, mitochondrial outer membrane permeabilization results in the release of cytochrome-c into the cytosol, leading to the formation of a large caspaseactivating complex, termed the "apoptosome". My project was focused on understanding the mechanisms of caspase-9 processing and activation within the apoptosome.
Jaekyoung Son, Ph.D.
My project focused on TRAIL, a member of the TNF receptor superfamily. I invested the intracellular mechanisms responsible for TRAIL resistance in human prostate cancer cells, with a particular focus on the role of p38 MAPKs in this process.
Shankar Varadarajan, Ph.D.
As a grad student in the Bratton Lab, I worked on two different research projects; one project dealt with the role of p38 MAPKs in regulating autophagy and lysosomal biogenesis, while the other project involved TNFR1 signaling and receptor trafficking mechanisms.
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Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.