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Pharmacology & Toxicology

Research and Graduate Training Faculty

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Bratton, Shawn B., Ph.D.
Adjoint Associate Professor of Pharm./Tox.
BME 3.510E
512-471-1735
sbbratton@austin.utexas.edu


Recent Publications

Bratton, S. B. and Salvesen, G. S. (2010) Regulation of the Apaf-1 · caspase-9 apoptosome. J. Cell Sci. 123, 3209-3214.

Son, J. K., Varadarajan, S., and Bratton, S. B. (2010) TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 17, 1288-1301.

Lau, S. S., Kuhlman, C. L., Bratton, S. B., and Monks, T. J. (2010) Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chem. Biol. Interact. 184, 212-217.

Malladi, S., Challa-Malladi, M., Fearnhead, H. O., and Bratton, S. B. (2009) The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 28, 1916-1925. [Reviewed in Science Signaling; Adrain, C. and Martin, S. J. (2009) Apoptosis: calling time on apoptosome activity. Sci. Signal. Oct. 6; 2(91):pe62].

Choi, Y. E., Butterworth, M., Malladi, S., Duckett, C. S., Cohen, G. M., and Bratton, S. B. (2009) The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing.  J. Biol. Chem. 284, 12772-12782.

Fisher, A. A., Labenski, M. T., Malladi, S., Gokhale, V., Bowen, M. E., Milleron, R. S., Bratton, S. B., Monks, T. J., and Lau, S. S. (2007) Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c. Biochemistry 46, 11090-11100.

Challa, M., Malladi, S., Varadarajan, S., Yin, Y. W., White, K., Bratton, S. B. (2007) Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 26, 3144-3156.

Milleron, R. S. and Bratton, S. B. (2007) Visions and Reflections: 'Heated' debates in apoptosis. Cell. Mol. Life Sci., 64, 2329-2333.

Yin, W., Mendenhall, J., Bratton, S. B., Oung, T., Janssen, W. G. M., Morrison, J. H. and Gore, A. C. (2007) Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals. Exp. Biol. Med. 232, 662-673.

Milleron, R. S. and Bratton, S. B. (2006) Heat shock induces apoptosis independently of any known caspase-activating complex. J. Biol. Chem. 281, 16991-17000.

Chandra, D., Bratton, S. B., Person, M.D., Tian, Y., Martin, A. G., Ayers, M., Fearnhead, H. O., Gandhi, V., Tang, D. G. (2006) Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome c and inhibiting apoptosome. Cell 125, 1333-1346.

Mufti, A. R., Burstein, E., Csomos, R. A., Graf, P. C. F., Wilkinson, J. C., Dick, R. D., Challa, M., Son, J.-K., Bratton, S. B., Su, G. L., Brewer, G. J., Jakob, U. and Duckett, C. S. (2006) XIAP is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Mol. Cell 21, 775-785.

Lewis, J., Burstein, E., Birkey-Reffey, S., Bratton, S. B., Roberts, A. B. and Duckett, C. S.  (2004)  Uncoupling of the signaling and caspase-inhibitory properties of XIAP.  J. Biol. Chem. 279, 9023-9029

Bratton, S. B. and Cohen, G. M. (2003) Death receptors leave a caspase footprint that 'Smacs' of XIAP.  Cell Death Differ. 10, 4-6.

Bratton, S. B., Lewis, J., Butterworth, M., Duckett, C. S., and Cohen, G. M. (2002) XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.  Cell Death Differ. 9, 881-892.

MacFarlane, M., Merrison, W., Bratton, S. B., and Cohen, G. M. (2002) Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.  J. Biol. Chem. 277, 36611-36616.

Bratton, S. B., Sun, X-M., Butterworth, M., MacFarlane, M., and Cohen, G. M. (2002) Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of XIAP.  J. Biol. Chem. 277, 11345-11351.

Bratton, S. B. and Cohen, G. M. (2002) Caspase cascades in chemically-induced apoptosis.  In:  Biological Reactive Intermediates VI (Dansette, et al., eds.), Klewer Academic/Plenum Press, pgs. 407-420.

Cain, K., Bratton, S. B. and Cohen, G. M. (2002) The Apaf-1 apoptosome: a large caspase-activating complex.  Biochimie 84, 203-214.

Bratton, S. B., Walker, G., Srinivasula, S. M., Sun, X-M., Butterworth, M., Alnemri, E. S. and Cohen, G.M. (2001) Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.  EMBO J. 20, 998-1009.

Bratton, S. B., Walker, G., Cain, K., and Cohen, G. M. (2001) Caspase-3 cleaves Apaf-1 into an ~30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive ~1.4 MDa apoptosome complex.  Cell Death Differ. 8, 425-433.

Bratton, S. B. and Cohen, G. M. (2001) Apoptotic death sensor:  an organelle1s alter ego.  Trends Pharmacol. Sci. 22, 306-315.

Cain, K., Bratton, S. B., Langlais, C., Walker, G., Brown, D. G., Sun, X-M. and Cohen, G. M. (2000) Apaf-1 oligomerizes into biologically active ~700-kDa and inactive ~1.4- MDa apoptosome complexes.  J. Biol. Chem. 275, 6067-6070.

Bratton, S. B., MacFarlane, M., Cain, K. and Cohen, G. M. (2000) Protein complexes activate distinct caspase cascades in death receptor and stress induced apoptosis.  Exp. Cell Res., 256, 27-33.

Bratton, S. B., Lau, S. S., and Monks, T. J. (2000) The putative benzene metabolite 2,3,5-tris-(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells.  Chem. Res. Toxicol. 13, 550-556.

Bratton, S. B., Lau, S. S., and Monks, T. J. (1997) Identification of quinol-thioethers in bone marrow of hydroquinone/phenol-treated rats and mice, and their potential role in benzene-mediated hematotoxicity.  Chem. Res. Toxicol. 10, 859-865.

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Last Reviewed: December 13, 2010

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


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> Read more about Dr. Erickson's new book.


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