The goal of work in the Gore Laboratory is to understand the neuroendocrine control of reproduction and sex differences in the brain during development and aging. We are interested in hormone actions (especially estrogens) in the brain, and perturbation of these processes by environmental hormone disruptors. One line of research focuses on molecular and cellular changes to the aging female hypothalamus, and estrogen effects on the aging brain as a model for menopause. A second line of research seeks to understand how prenatal exposure to environmental endocrine disruptors (EDCs) causes molecular epigenetic modifications and cellular changes to the developing hypothalamus and the manifestations of these effects later in life, and transgenerationally. The outcomes of this developmental reprogramming by EDCs include perturbations in brain structure, neural phenotypic properties, and sexually dimorphic behaviors in adulthood. Our team uses comprehensive behavioral, physiological, neuroanatomical, immunohistochemical (light and electron microscopy), and molecular approaches to address these questions on the neurobiological control of reproduction across the life cycle.
Dr. Gore is also the Editor-in-Chief for Endocrinology
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Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.