Gore, Andrea C., Ph.D.
Gustavus and Louise Pfeiffer Professor
PHR 5.218D
512-471-3669
andrea.gore@mail.utexas.edu

Sarah Dickerson

Background:
I graduated from Sam Houston State University in 2001 with a B.S. in Biology. Following graduation, I worked as an analytical chemist until I began my graduate career at the University of Texas at Austin in June 2004. My research was funded by a one-year appointment to the Toxicology Training Grant, and I currently am supported by a three-year National Science Foundation Graduate Research Fellowship. 

Research:
My research focuses on the impact of a class of environmental toxicants known as endocrine disrupting chemicals (EDCs) on the development of brain regions that control reproduction. There are distinct morphological and functional differences between male and female central nervous systems, a phenomenon known as sexual dimorphism. These differences are predominantly regulated by steroid hormones, and are permanent, taking shape during perinatal development. The early organizational effects of hormones on the developing nervous system are critical. If they are disrupted, adult reproductive sexual behaviors and reproductive physiology are permanently compromised. The goal of my dissertation research is to elucidate the cellular and molecular mechanisms by which normal developmental brain sexual differentiation is disrupted by polychlorinated biphenyls (PCBs), a class of persistent EDCs. In my experimental model, developing fetal rats are exposed to PCBs during brain sexual differentiation. My hypothesis is that PCBs perturb normal developmental apoptosis (programmed cell death) in brain regions that contribute to sexual differentiation of the brain in infancy, and lead to latent abnormalities in adult reproductive behavior and function. To this end, I have focused on a group of cells in the neuroendocrine hypothalamus that control reproductive function. This population of neurons synthesizes and releases a peptide called gonadotropin-releasing hormone (GnRH). In order for GnRH neurons to function properly, they require regulatory inputs from other hypothalamic brain regions, and I will study one of the most sexually dimorphic regions in this regard: the anteroventral periventricular nucleus (AVPV). In a series of studies, I will evaluate the impact of PCB exposure on expression of cell survival and apoptotic factors during postnatal development, gene and protein expression of GnRH and nuclear hormone receptors, and morphology of the AVPV. In addition to cellular and molecular effects, PCBs may cause permanent changes that are manifested during the pubertal process, during which endogenous steroid hormone production increases and activates the sex-specific brain morphology and neurochemistry organized during early postnatal life. Therefore, I will also ascertain the repercussions of prenatal PCB treatment on the attainment and manifestation of adult reproductive functions. These studies will ultimately provide insight into the actions of PCBs on the reproductive axis of developing mammals at a fundamental level, and will provide important new information regarding the mechanisms by which PCBs disrupt the endocrine system.

Publications:
Dickerson SM, Walker DM, Reveron ME, Duvauchelle CL and Gore AC (2007). The Recreational Drug Ecstasy Disrupts the Hypothalamic-Pituitary-Gonadal Reproductive Axis in Adult Male Rats. Neuroendocrinology (accepted; in press).

Dickerson SM and Gore AC (2007). Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle. Reviews in Endocrine and Metabolic Disorders. 8(2):143-59.

Sailer BL, Liles N, Dickerson S, Sumners S and Chasteen TG (2004). Organotellurium Compound Toxicity in a Promyelocytic Cell Line Compared to a Non-Tellurium Containing Organic Analog. Toxicology in Vitro. 18:475-482.

Sailer BL, Liles N, Dickerson S and Chasteen TG (2003). Cytometric Determination of Novel Organotellurium Compound Toxicity in a Promyelocytic (HL-60) Cell Line Archives of Toxicology. 77:30-36.

Sailer BL, Prow T, Dickerson S, Watson J, Liles N, Patel SJ, Van Fleet-Stalder V and Chasteen TG (1999). Bacterial Cytotoxicity and Induction of Apoptosis in Promyelocytic (Line HL-60) Cells by Novel Organotellurium Compounds.  Environmental Toxicology and Chemistry. 18(12):2926-2933.

Ross Gillette

Background:
I am a 3rd year neurobiology and psychology major at the University of Texas at Austin. I am a Resident Advisor at Jester East, a peer advisor with the Biological Sciences advising office, and I am passionately involved with Best Buddies International.

I first heard about the Gore lab from a previous professor who suggested it based on my interest in neuroscience, and I have loved being a part of the group ever since joining it over a year ago.  After graduation, I hope to attend medical school.

I am currently working with a Neuroscience graduate student Jackie Maffucci on a project concerning the prevalence of the expression of the NR2b subunit of the NMDA receptor in the anteroventral paraventricular nucleus (AVPV) of the hypothalamus. The NMDA receptor is a part of the neuronal circuitry that controls reproductive functions, and the NR2b subunit of this receptor appears to be particularly important in this role. We are quantifying the expression of the NR2b subunit protein and determining its regulation by both the age of the animals as well as hormone replacement therapies. This research will provide insight into both the role of the brain in reproductive aging, as well as how the brain is able to respond to hormones, such as estrogens, during this aging process. My contribution to the project lies in the labeling of the NR2b protein in the hypothalamic AVPV tissue (immunohistochemistry) and in the quantification of individual neurons in the hypothalamus that are expressing this particular protein (stereology).

Justin Jefferson

I am a third year human biology/ pre-medical student at the University of Texas at Austin. The Intellectual Entrepreneurship program and my passion for scientific research led me to Dr. Gore's laboratory. I began working in Dr. Gore's laboratory in fall 2007 as a volunteer and became an official member in the spring of 2008. I am a member of the Kinesiology Club, a volunteer at Dell's Children's Hospital, a member of the Intellectual Entrepreneurship program, and a U.T. Presidential Scholarship recipient. After graduation, I plan to attend medical school or graduate school.

The Gore lab is a great community of scientists.  I am currently working with a Neuroscience graduate student, Deena Walker on her research project, which is focused on the mechanisms for the control of the onset of puberty. We use quantitative real-time PCR (polymerase chain reaction) to measure mRNA levels of GnRH and steroid hormone receptors. I contribute to this research by carrying out the PCR reactions for the puberty project Deena is working on. I have also learned how to do the ovariectomy surgery for Dr. Gore's work on reproductive aging, and I will be doing real-time PCR measurements of gene expression in the brains of these animals.

Publications:

• Jefferson JR (2008). Jefferson: Creating a phalanx of citizen-scholars. Star-Telegram (Fort Worth, TX).
• Jefferson JR (2008). Finding a niche at UT. Daily Texan (Austin, TX).
• Jefferson JR (2008). Path to the future is no longer lonely. Austin American-Statesman (Austin, TX).
• Jefferson JR (2008). A Head Start. The Scientist. Vol. 22: page 25
• Jefferson JR (2008). Housing Projects to Research Projects. The Alcalde (Austin, TX).

Honors:

• University of Texas at Austin, Featured story, Exploring All the Options, 2008
• University of Texas at Austin, Guest Speaker at Gone to Texas, 2008

Tyler Merceron

I am currently in my 3rd year at The University of Texas at Austin, majoring in both Plan II Honors (B.A.) and Cell & Molecular Biology (B.S.).  I am currently involved in various organizations on campus and hold leadership roles in Beta Beta Beta (a national Biological Honor Society) and the Longhorn Premedical Student Association.  While I am dedicated primarily to my studies, I am also a saxophone player, play soccer and am a 2nd-degree black belt in TaeKwonDo and I weekly mentor a middle-school student at a local junior high school.   Following graduation, I plan to pursue a career in medicine.

I joined the Gore Lab in Spring 2008 as a volunteer after hearing about the lab's dedication to training undergraduates from my Genetics TA.  I am currently working with graduate student Michelle Naugle on a project involving hormone receptor expression (both the Estrogen Receptor-alpha (ERa) and the Progesterone Receptor (PR)) in the hypothalami of aged versus young monkey specimens.  We are using immunohistochemistry to label these receptors and stereology as a means to quantify the number of neurons labeled.  Insight into the change in number of sex hormone receptors in the aged monkey brain will provide information important to the study of female reproductive senescence (menopause) and possible human therapies.

Monique "Mo" Monita

Background
A senior at the University of Texas at Austin, I've been a member of the Gore Lab since the summer of 2005. I've been affiliated with the American Medical Student Association, Science Undergraduate Research Group, and the Texas Interdiscplinary Plan. From August 2007 to May 2008, I studied abroad in Copenhagen, Denmark to fulfill my minor requirements and give the Gore lab a break from my shenanigans. After graduation I plan to attend medical school in hopes of becoming a physician scientist.

Research
In the Gore Lab, the bulk of my research has been in collaboration with Weiling Yin, the now resident postdoctoral researcher. During this time, I studied the expression of estrogen receptor-alpha on glia and neurons in the median eminence of the hypothalamus. Furthemore, I assisted in creating three-dimensional reconstructions of GnRH neuroterminals. After coming back from abroad, I'm now working with another graduate student in the lab, Sarah Dickerson. Together, we are studying the effects of endocrine disrupting chemicals (EDCs) on the developing brain, specifically the sexually dimorphic nuclei. Polychlorinated biphenyls (PCBs) are a particular class of EDCs that are prominent within the environment. If alterations in sexually dimorphic nuclei arise within the brain due to PCBs, such regions may become feminized, de-feminized, masculinized, or de-masculinized. These structural changes may be manifested in reproductive function and behavior. I've hypothesized that perinatal exposure to PCBs causes a change in the adult AVPV volume and the number of neurons exhibiting ER-alpha immunopositive nuclei and I'm currently in the stages of testing this hypothesis.

Research Interships
Neuroendocrine Clinical Research, Laurence Katznelson, M.D., Department of Neurosurgery, The Pituitary Center, Stanford University School of Medicine, Summer 2008 
                                               
Neuroendocrine Laboratory Research, Michael Woller, Ph.D., College of Letters & Sciences, University of Wisconsin- Whitewater, Summer 2006

Abstracts
Sarah M. Dickerson, Stephanie Cunningham, Monique Monita, Andrea C. Gore (2009) Perinatal exposure to PCBs disrupts sexual differentiation of the reproductive neuroendocrine axis. The Endocrine Society's 2009 International Meeting, Washington, D.C.

Weiling Yin, Monique M. Monita, Sharon Kin, Di Wu, Andrea C. Gore (2008) GnRH Neuroterminal Changes and Interaction with Glia in Reproductive Aging. The Endocrine Society's 2008 International Meeting, San Fransisco, California.

Weiling Yin, Monique M. Monita, Kristen K. Reynolds, Di Wu, Jacqueline A. Maffucci, Andrea C. Gore (2007) GnRH Neuroterminal Properties in Reproductive Aging. The Endocrine Society's 2007 International Meeting, Toronto, Canada.
                       
Honors          
Texas IP Research Scholarship, Spring 2008
Danish Institue for Study Abroad Scholarship, Fall 2007 & Spring 2008
Howard Hughes Medical Institute International Undergraduate Research Fellowship, Fall 2007
Cleo Seelinger Scholarship, Spring 2007
Texas IP Study Abroad Scholarship, Spring 2007
Texas IP Research Scholarship, Spring 2007
International Education Fee Scholarship, Spring 2007
University of Texas Co-operative Society Undergraduate Research Fellowship, Fall 2006
Louis Stokes Alliance for Minority Participation Program Research Fellowship, 2005-2006

Michelle Naugle

I graduated Magna cum laude from Georgia State University with a B.S. in Neuoscience in December of 2006. While earning my degree I worked in Dr. Paul Katz's lab studying serotonergic modulation of the central pattern generator that controls the escape swim behavior of the mollusk Tritonia diomedea.

I joined Dr. Gore's lab in the spring of 2008. I am interested in how the brain compensates for the changes in hormone levels that accompany menopause. I will be investigating how the hypothalamus responds to hormone treatment at different ages. I am currently looking at changes in hormone receptor expression using immunohistochemistry, and will soon be looking at ultra-structural changes with electron microscopy.

Published Abstracts:

• Sakurai A, Calin-Jageman RJ, Naugle M, & Katz PS. (2005). Serotonergic enhancement of transmitter release mediates the synaptic potentiation phase of spike timing-dependent neuromodulation. Society for Neuroscience Abstracts, 31, 177.13.
• Sakurai A, Calin-Jageman RJ, Naugle M, & Katz PS. (2006). Serotonergic enhancement of transmitter release mediates the synaptic potentiation phase of spike timing-dependent neuromodulation. Southeast Nerve Net.

Honors:

• Georgia State University, Howard Hughes Biotechnology Fellowship, 2006

Selena Ng

I am a third year Human Biology major, concentrating on social aspects of health and disease. I'm interested in pursuing medicine after my undergraduate studies are completed, so I've been working as a volunteer around hospitals in Austin and Houston, my hometown, and I have also completed an internship at Baylor College of Medicine. I hope to get an MD/MPH and utilize that degree to do both research in infectious disease, like malaria, in addition to practicing medicine. My interest in research brought me to Dr. Gore's lab in Fall 2007, and starting in Summer 2008 I have been working on a research project alongside Karla Resendiz, a PharmD student.

My research project investigates the expression of a newly discovered estrogen receptor, GPR30, on GnRH neuroterminals in the median eminence of the aging rat brain. GPR30 is unique from the classical estrogen receptors ER alpha and ER beta in that it is situated at the membrane surface of cells, rather than in the nucleus. Thus, it can induce affects quickly through a system of second messengers, whereas the classical steroid receptors take a relatively longer time to act, as they generally act as transcription factors and cause changes in DNA expression. The mechanism of action of estrogen on GnRH neurons is still a mystery; the major classical estrogen receptor, ER alpha, has not been found on GnRH neurons, and ER beta, while present on these neurons, does not seem to elicit this switch in feedback responses. However, preliminary results on my project show that the new membrane estrogen receptor, GPR30, could in fact be expressed on GnRH terminal in the median eminence. The presence of GPR30 on GnRH neurons could be the missing link in this story. I am investigating how this expression pattern changes with aging and hormone treatment in the rat using double-labeling for GPR30 and GnRH in median eminence tissues of aging rats.

Megan Noel

Background:
As a comparative endocrinologist, I have worked in several interesting models systems. As an undergraduate at the University of Texas at Austin I worked with Dr. Creagh Breuner (now at the University of Montana) to look at physiological stress in mountain white-crown sparrows (Zonatrichia leucophrys) induced by environmental stimuli, and how corticosteroid binding proteins affect the stress response in these birds. It was in this lab that I began cloning genes in nontraditional system; with the help of Mary Ramsey from the lab of Dr. David Crews, I cloned a fragment of the avian corticosteroid binding protein from the house sparrow (Passer domesticus). From here I went on to get a Masters degree in Marine Science through the UT- Marine Science Institute. While working with Dr. B. Scott Nunez, I cloned the first elasmobranch form of 11beta hydroxylase, and examined how stress affects the level of transcript of steroidogenic enzymes in several regions of the Atlantic stingray (Dasyatis sabina) brain. Now, as a technician in the Gore lab I facilitate and assist with research being done by the students working on their various projects in the lab, which includes projects dealing with reproductive behavior, immunohistochemistry, and molecular work in rats, rabbits and monkeys. One project that I am focusing on involves investigating the ultrastructural changes in GnRH neurons in the hypothalamus of rabbits that have been treated with the fungicide vinclozolin, a project done in collaboration with the labs of Drs. Stuart Tobet and Rao Veeramachaneni of Colorado State University. I am also beginning to investigate the ultrastructure of GnRH neurons and how these change in the hypothalamus of aging rats and monkeys treated with different reproductive steroid hormones.

Publications

• Noel, M., Ramsey, M, Crews, D. and Breuner, C. 2004. Cloning and characterization of Corticosteroid Binding Globulin (CBG) in an avian species, Passer domesticus. Annual Meeting of the Society-for-Integrative-and-Comparative-Biology, January 04 -08, 2005, San Diego, CA, USA
• Noel, Megan L. 2006. The effect of stress on steroidogenic gene transcription in the Atlantic stingray brain. Thesis, The University of Texas at Austin. Supervisor: B. Scott Nunez
• Noel, M.L., and Nunez, B.S. 2006. Steroidogenic capacity of the Atlantic stingray (Dasyatis sabina) brain. Annual Meeting of the Society-for-Integrative-and-Comparative-Biology, January 03 -07, 2007, Phoeniz AZ, USA

Karla Resendiz

Background:
I am currently working on my PharmD degree at the University of Texas at Austin College of Pharmacy. I am originally from Rockwall, Texas. In my spare time I like to read, relax and enjoy life. I am looking forward to doing rotations in a clinical pharmacy setting, where I hope to learn more about oncology, neonatology, and how pharmacists affect clinical outcomes.

Research:
My Honors Project consists of documenting the expression of membrane ER-alpha receptors on the median eminence of the rat brain. Currently I am working with enzymatic DAB immunochemistry in order to test and optimize 3 different antibodies specific to this receptor. In the future, I hope to determine if membrane ER-alpha receptors are co-localized with GnRH receptors on the median eminence of the rat brain.

Deena Walker

Background:
I graduated from UT in 2002 with a B.S. in biology. As an undergraduate, I worked under Dr. Tom Mabry studying the estrogenic nature of compounds extracted from several plant species native to central Texas. Following this, I began research in the lab of Dr. Su Dharmawardhane and was given an independent project determining the role of TGF-Beta in breast cancer metastasis. In addition to my work in research laboratories, I worked with Dr. Delia Brownson, supervising the preparations for the upper and lower-division molecular biology lab courses at UT-Austin.
After graduation, I was hired as a technician in Dr. Cheryl Walker's laboratory at the MD Anderson Cancer Center, Research Division in Smithville, TX. While there, I studied the effects of diethylstilbesterol (DES) on the development of uterine leiomyomas in rats. The research I conducted in Dr. Walker's lab was instrumental in establishing an interest in endocrine disrupting chemicals (EDCs) and their effects on the developing fetus.
I worked for two years as a technician in Dr. Gore's laboratory prior to graduate school. While there, I served as the molecular biology specialist for the lab. I established a real-time PCR protocol and developed assays to substitute for our RNase Protection Assay (RPA) protocols, such as assays measuring the primary transcript for GnRH. I was involved in a number of molecular based projects, but was interested in those projects concerning EDCs and development in rats. I completed my own project which sought to elucidate the role of GnRH gene expression in pubertal development in male rats using real-time PCR.

Research:
I started graduate school in 2006. Since being in graduate school, I have expanded my interest in the molecular mechanisms underlying the onset of puberty in rats by studying gene expression changes in sex steroid hormone receptors in the developing preoptic area. Along with Lorenzo Perez, an undergraduate in our lab, I have also begun work identifying sex differences in gene expression in both the preoptic area and the medial basal hypothalamus. We are also interested to determine if the changes in gene expression that we have observed are associated with changes in serum hormone concentrations. Finally, I would like to determine if developmental exposure to EDCs can alter the gene expression profiles in both male and female rats. Together, I hope these studies will help to identify basic molecular mechanisms required for the onset of puberty in mammals.

Published Papers:

1. Walker DM, Gore AC (2007) Endocrine-disrupting chemicals and the brain. In: Gore AC (ed), Handbook of Endocrine-disrupting Chemicals, Humana Press, pp 63 - 109.


2. Dickerson SM, Walker DM, Reveron ME, Duvauchelle CL, Gore AC (2008) The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats. Neuroendocrinology 88(2):95-102.


3. Maffucci JA, Walker DM, Ikegami A, Woller MJ, Gore AC (2008) The NMDA receptor subunit NR2b: Effects on LH release and GnRH gene expression in young and middle-aged rats, with modulation by estradiol. Neuroendocrinology 87(3):129-41.


4. Steinberg RM, Walker DM, Juenger TE, Woller MJ, Gore AC (2008) The effects of perinatal PCBs on adult female reproduction: Development, reproductive physiology, and second generational effects. Biology of Reproduction 78(6):1091-101.


5. Walker DM, Juenger TE, Gore AC (2009) Developmental profiles of neuroendocrine gene expression in the preoptic area in the male rat. Endocrinology (in press).

Abstracts:

1. Walker DM, Dubash A, Dharmawardhane SF, (2001) TGFB Signaling in Breast Cancer Progression, Undergraduate Research Poster Session, March 23, 2001 and UT-Austin Molecular Cell and Developmental Biology Departmental Retreat, March 31, 2001.
   


2. Gore AC, Steinberg RM, Walker DM (2005) Endocrine disrupting effects of PCBs on reproductive neuroendocrine function. Gulf Coast Society of Toxicology, Austin, TX.
   


3. Steinberg RM, Walker DM, Gore AC (2005) Altered adult gene expression following prenatal PCB exposure - a microarray study. Gulf Coast Society of Toxicology, Austin, TX.
   


4. Gore AC, Steinberg RM, Walker DM (2005) Fetal PCB exposure disrupts reproductive physiology and behavior in adulthood. NIEHS Grantee Meeting, Durham, NC.
   


5. Walker DM, LaPlant Q, Maffucci JA, Gore AC (2005) Hypothalamic GnRH gene expression profile in developing male rats, assayed by two quantitative methods. Endocrine Society, San Diego, CA.
   


6. Walker DM, LaPlant Q, Maffucci JA, Gore AC (2005) Hypothalamic GnRH gene expression profile in developing male rats, assayed by two quantitative methods. Endocrine Society Forum on Endocrine-Disrupting Chemicals, San Diego, CA.
   


7. Steinberg RM, Walker DM, Gore AC (2005) Prenatal PCB exposure results in altered development and sexual behaviors in female rats. Endocrine Society Forum on Endocrine-Disrupting Chemicals, San Diego, CA.
   


8. Dickerson SM, Walker DM, Steinberg RM, Dangleben NL, Gore AC (2005) Mechanisms for polychlorinated biphenyl actions on GnRH development. Endocrine Society Forum on Endocrine-Disrupting Chemicals, San Diego, CA.
   


9. Dickerson SM, Walker DM, Steinberg RM, Dangleben NL, Gore AC (2005) Mechanisms for Aroclor 1221 actions on GnRH development. SETAC South Central Regional Meeting, Marble Falls, TX.
   


10. Dickerson SM, Reveron ME, Walker DM, Duvauchelle CL, Gore AC (2006) MDMA disrupts the reproductive axis in male rats. Endocrine Society, Boston, MA.
    


11. Maffucci JA, Walker DM, Makos B, Woller MJ, Gore AC (2006) The NMDA receptor subunit NR2b affects GnRH gene expression and LH release in female rats, with modulation by estrogen but not aging. Endocrine Society, Boston, MA.
    


12. Steinberg RM, Walker DM, Juenger T, Gore AC (2006) Prenatal PCBs induce altered gene expression in the preoptic area of the female rat. Endocrine Society, Boston, MA.
    


13. Walker DM, Gore AC (2007) Neuroendocrine gene expression In the preoptic area in male rats: Effects of development and castration. Endocrine Society, Toronto ON.
    


14. Walker DM, Perez LF, Gore AC (2008) Sex differences in neuroendocrine gene expression in the preoptic area (POA) throughout development. Endocrine Society, San Francisco, CA.
    


15. Perez LF, Walker DM, Gore AC (2008) Neuroendocrine gene expression in the medial basal hypothalamus (MBH) throughout postnatal development, Endocrine Society, San Francisco, CA.

Di Wu

Background:
I received my Bachelor of Science in Environmental Biology in 2000 and Master of Science in the same major in 2003, both from Nanjing University in China. I came to the United States in 2003 to begin my Ph.D. work in Dr. Andrea Gore's laboratory.

Research:
My current research investigates the effects of aging on reproductive function in male rats to see whether testosterone and estradiol still play important roles in shaping masculine behavior and physiology in older adulthood. In general, I am looking at altered sex steroid hormone levels with aging along with alterations in the numbers and distribution of steroid hormone receptors. Specifically, I am looking at a negative regulation of the density of androgen receptors in response to declining testosterone and a compensatory up-regulation of the density of estrogen receptors, in the hypothalamus and POA. In addition, I am also seeking to determine whether exogenous testosterone treatment can change the alternation of hormone receptor expression in old male rats. My dissertation research will also include the effects of experience on hormones and hormone receptor expression in the brain.

Publications:

1. Wang G, Milner TA, Speth RC, Gore AC, Wu D, Iadecola C, Pierce JP (2008) Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla. American Journal of Physiology, Regul Integr Comp Physiol, 295: R1149-R1157.


2. Wu D, Lin G, Gore AC (2009) Age-related changes in hypothalamic androgen receptor and estrogen receptor a in male rats. Journal of Comparative Neurology 512 (5): 688-701.

Abstracts:

1. Gore AC, Maffucci JA, Reynolds K, Wu D, Yin W (2005) Rat models of reproductive aging (and what does the NMDA receptor have to do with menopause?). Cold Spring Harbor Laboratories Symposium on Rat Models & Genomics, Cold Spring Harbor, NY.


2. Wu D, Kristobak EE, Gore AC (2006) Do estrogen receptor numbers decrease in the aging male hypothalamus? Endocrine Society Abst, Boston, MA.


3. Wagner T, Wu D, Garcia Y, Chin L, Walker DM, Steinberg RM, Gore AC (2007) The effects of gestational ethinyl estradiol exposure on reproductive development and function in adulthood. Endocrine Society Abst., Toronto, Canada.


4. Wu D, Lin G, Gore AC (2007) Androgen receptor and estrogen receptor a cell numbers in the medial preoptic nucleus (MPN) of aging male rats. Endocrine Society Abst., Toronto, Canada.


5. Yin W, Monita MM, Reynolds KK, Wu D, Maffucci JA, Gore AC (2007) GnRH neuroterminal properties in reproductive aging. Endocrine Society Abst., Toronto, Canada.


6. Gore AC, Wu D, Yin W, Chakraborty TR (2008) Hormone receptors in the brain and relevance to reproductive aging. Experimental Biology Abst, San Diego, CA.


7. Wu D, Gore AC (2008) Differential effects of castration and testosterone replacement on sexual behavior in young and middle-aged male rats. Endocrine Society Abst., San Francisco, CA.


8. Yin W, Monita MM, Kim S, Wu D, Gore AC (2008) GnRH neuroterminal changes and interaction with glia in reproductive aging. Endocrine Society Abst., San Francisco, CA.