Postdoctoral Fellow, Department of Pharmacology & Toxicology
Background: Originally from Michigan, I graduated from Boston University in 2006 with a bachelors degree in Biology, specializing in Neuroscience. While in Boston, I worked with Dr. Caroly Shumway at the New England Aquarium studying differences in navigational abilities between two species of cichlid fish and how they relate to differences in habitat complexity and telencephalon volume.
Current Research: I joined the Gore Lab at the University of Texas at Austin as a Postdoctoral Fellow in June 2012. Given the known susceptibility of the perinatal brain to the effects of endocrine disruptors, and the normal organizational effects of hormones on the brain during puberty, I am determining the relative contributions and interactions of PCB exposure during these important developmental periods. As social and anxiety behaviors change dramatically during adolescence, often in a sexually-dimorphic and hormone sensitive way, I am also studying the effects of PCB exposure on play and sociosexual ultrasonic vocalizations, sociability, and anxiety-like behavior. Additionally, I am investigating associated gene expression changes in hypothalamic, amygdalar, and corticolimbic brain regions. Continued work will seek to determine the molecular mechanisms for such changes, including DNA methylation and miRNA.
For lists of honors and awards, publications, and posters, please see c.v. (pdf)
Graduate Student, Department of Psychology
Background: I graduated from Arizona State University in 2010 with a B.S. in Psychology. During my time at ASU, I worked in Dr. Heather Bimonte-Nelson’s memory and aging research laboratory studying the effects of estrogen and progesterone on cognitive and neurobiological endpoints using various rodent models of menopause. In summer 2010, I participated in the summer fellowship program at The Center for Neuroscience at the University of Pittsburgh (CNUP) and worked under the mentorship of Dr. Anthony Kline. Our research focused on optimizing rehabilitation treatment after traumatic brain injury. Specifically, we investigated the role of neurogenesis in environmental enrichment-mediated behavioral benefits in rats after experimental traumatic brain injury.
Current Research: I am currently a 3rd year graduate student in the Psychology department in the Behavioral Neuroscience area. I joined the Gore lab in the summer of 2011. Since joining the lab I have become interested in studying behavioral, molecular, and neuroanatomical components of social functioning. My main research focus is studying how timing and duration of estradiol (E2) treatment (relative to ovariectomy, as a model for hormone deprivation) affect social interaction and social memory. I look at the underlying molecular and cellular changes in the brain by using real-time PCR. Tissues from the behaviorally characterized rats are used to determine effects of aging and E2 timing/duration on some of the neural circuits that underlie social behaviors. In the future I plan on using immunohistochemistry and stereological counting to assess protein expression and neuroanatomical localization. My choices of protein targets and brain regions will be determined by the most robust qPCR results. The implications of this work are relevant to all women undergoing menopause or surgical oophorectomy and may guide novel estrogen therapeutic strategies with respect to the timing and to identify the shortest possible duration to minimize risk.
Wolf A. B., Braden B. B., Bimonte-Nelson H., Kusne Y., Young N., Engler-Chiurazzi E., Garcia A. N., Walker, D. G., Moses, G. S., Tran H., Laferla F., Lue L., Emerson Lombardo N., and Valla, J. (2012). Broad-based nurtritional supplementation in 3xTg Mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer’s disease intervention. The Journal of Alzheimer’s Disease 1;32 (1):217-232.
Garcia, A. N., Shah, M. A., Dixon, C. E., Wagner, A. K., and Kline, A. E. (2011). Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation. PMR 3:S18-S27.
Braden, B. B., Garcia, A. N., Mennenga, S. E., Prokai, L., Villa, S. R., Acosta, J. I., Lefort, N., Simard, A. R., and Bimonte-Nelson, H. A. (2011). Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time. Psychopharmacology 218 (2):405-418.
Dang, N. V., Garcia, A. N., Jones, T. A., Gore, A. C., and Yin, W. Hormone treatment and fine motor skill learning in middle-aged rats. Society for Neuroscience, 2012.
Phelps, T. I., McAloon, R. L., Yelleswarapu, N. K., Garcia, A. N., Shah, M. A., Cheng, J. P., and Kline, A. E. The therapeutic efficacy of aripiprazole after experimental traumatic brain injury. J Neurotrauma, 28:A103, 2011; and Program No 462.08, 2011 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011.
Garcia, A. N., Shah, M. A., and Kline, A. E. The role of neurogenesis in environmental enrichment-mediated behavioral benefits after experimental traumatic brain injury. Safar Center for Resuscitation Student Research Day, University of Pittsburgh, 2010.Talboom, J. S., Engler-Chiurazzi, E., Whiteaker, P., Simard, A., Scheldrup, M., Cosand, M., Garcia, A. N., Mennenga, S., Bowman, B., Lukas, R., Prokai, L., and Bimonte-Nelson, H.A. Components of the most commonly prescribed hormone therapy improve cognition, alter nicotinic binding sites in cognitive brain regions and suppress luteinizing hormone in the surgically menopausal rat. Society for Neuroscience, 2009.
Ph.D. candidate, Institute for Neuroscience
Graduate Student, Department of Pharmacology & Toxicology
I received a B.S in biology at the University of Texas-Pan American (Now UT-RGV) in 2011 where my research focused on the hormonal effects of chronic, low-dose arsenic exposure in rats. I moved to Austin and joined the Gore lab during the the summer of 2011. I'm currently a 3rd year graduate student in the Pharmacology & Toxicology division within the College of Pharmacy. My ongoing research investigates the mechanism(s) by which polychlorinated biphenyls (PCBs) may serve as an endocrine disrupting chemical (EDC). Exposure to PCBs during particularly sensitive periods of neuronal development could lead to dysfunctional physiology and behavior in adulthood. I'm especially interested in the neuroendocrine processing of social behavior and how PCBs may alter this complex system.
Laboratory and Project Manager
I graduated from the University of North Texas in 2008 with a B.S. in Biochemistry. After graduating I worked at UT Southwestern where I helped to develop transgenic rats and improved the cell culturing methods involved in maintaining rat spermatogonial stem cells.
More information about Dr. Gore
> Gore CV (PDF File)
> Publications & PDFs
> Articles/Editorials written as Editor-in-Chief of Endocrinology
> Gore Lab Members
> Gore Lab Alumni
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Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.