Kiguchi, Kaoru, M.D., Ph.D.
Long-term collaboration with Dr. John DiGiovanni (DPRI) have led to the generation of valuable transgenic animal model for the studies the role of STAT3 and Akt in the skin carcinogenesis and in keratinocyte stem cell survival and proliferation. In addition, our research is focused on the role of Stat3 in the development of psoriatic skin.
Psoriasis is the most common autoimmune disease of the human skin, affecting approximately 2% of the population worldwide. Patients with psoriasis typically have sharply demarcated chronic erythematous plaques covered by silvery white scales, which most commonly appear on the elbows, knees, scalp, umbilicus, and lumber area. Psoriasis can be a highly disabling disease that may impact a patient’s quality of life significantly. It is a chronic inflammatory disease characterized by the local activation of conventional dendritic cells (cDCs) and autoimmune T cells that trigger the abnormal proliferation and differentiation of keratinocytes in genetically susceptible individuals.
Our previous study has shown that Stat3 was activated in keratinocytes in the majority of human psoriatic lesions examined and that constitutive activation of Stat3 in keratinocytes leads to development of skin lesions that recapitulate human psoriasis both clinically and histologically in the transgenic mice, in which Stat3 is constitutively active in keratinocytes (K5.Stat3C mice). It has been suggest that activation of plasmacytoid DCs (PDCs) to produce IFN-a in the skin represents a key innate immune pathway to initiate the autoimmune T cell cascade leading to psoriasis. Currently, our research is focusing on investigating the role of PDCs during the development of psoriasis and the effect of Stat3 activation on the distribution of PDCs.
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.