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Pharmacology & Toxicology

Research and Graduate Training Faculty

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Marinelli, Michela, Ph.D.
Associate Professor of Pharm./Tox.
BME 6.114A
512-471-0080
micky.marinelli@austin.utexas.edu


Publications Peer-reviewed journals 
  1. Catalani A, Marinelli M, Scaccianoce S, Nicolai R, Muscolo LAA, Korànyi L, Piazza PV, Angelucci L. Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance. Brain Res (1993) 624:209-215.

  2. Marinelli M, Piazza PV, Deroche V, Maccari S, Le Moal M, Simon H. Corticosterone circadian secretion differentially facilitates dopamine-mediated psychomotor effect of cocaine and morphine. J Neurosci (1994) 14:2724-2731.

  3. Jodogne C, Marinelli M, Le Moal M, Piazza PV. Animals predisposed to develop amphetamine self-administration show higher susceptibility to develop contextual conditioning of both amphetamine-induced hyperlocomotion and sensitization. Brain Res (1994) 657:236-244.

  4. Piazza PV, Marinelli M, Jodogne C, Deroche V, Rougé-Pont F, Maccari S, Le Moal M, Simon H. Inhibition of corticosterone synthesis by metyrapone decreases cocaine-induced locomotion and relapse of cocaine self-administration. Brain Res (1994) 658:259-264.

  5. Deroche V, Marinelli M, Maccari S, Le Moal M, Simon H, Piazza PV. Stress-induced sensitization and glucocorticoids. I Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion. J Neurosci (1995) 15:7181-7188.

  6. Rougé-Pont F, Marinelli M, Le Moal M, Simon H, Piazza PV. Stress-induced sensitization and glucocorticoids. II Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. J Neurosci (1995) 15:7189-7195.

  7. Marinelli M, Le Moal M, Piazza PV. Acute pharmacological blockade of corticosterone secretion reverses food restriction-induced sensitization of the locomotor response to cocaine. Brain Res (1996) 724:251-255.

  8. Piazza PV, Barrot M, Rougé-Pont F, Marinelli M, Maccari S, Abrous N, Simon H, Le Moal M. Suppression of glucocorticoid secretion and antipsychotic drugs have similar effects on the mesolimbic dopaminergic transmission. Proc Natl Acad Sci USA (1996) 93:15445-15450.

  9. Marinelli M, Rougé-Pont F, De Jésus Oliveira C, Le Moal M, Piazza PV. Acute blockade of corticosterone secretion decreases the psychomotor stimulant effects of cocaine. Neuropsychopharmacology (1997) 16:156-161.

  10. Marinelli M, Rougé-Pont F, Deroche V, Barrot M, De Jésus Oliveira C, Le Moal M, Piazza PV. Glucocorticoids & behavioral effects of psychostimulants I: Locomotor response to cocaine depends on basal levels of glucocorticoids. J Pharm Exp Ther (1997) 281:1392-1400.

  11. Deroche V, Marinelli M, Le Moal M, Piazza PV. Glucocorticoids & behavioral effects of psychostimulants II: Cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels. J Pharm Exp Ther (1997) 281:1401-1407.

  12. Marinelli M, Aouizerate B, Barrot M, Le Moal M, Piazza PV. Dopamine-dependent responses to morphine depend on glucocorticoid receptors. Proc Natl Acad Sci USA (1998) 95: 7742-7747.

  13. Marinelli M, Le Moal M, Piazza PV. Sensitization to the motor effects of contingent infusions of heroin but not of k agonist RU 51599. Psychopharmacology (1998) 139:281-285.

  14. Marinelli M, Barrot M, Simon H, Oberlander C, Dekeyne A, Le Moal M, Piazza PV. Pharmacological stimuli decreasing nucleus accumbens dopamine can act as positive reinforcers but have a low addictive potential. Eur J Neurosci (1998) 10:3269-3275.

  15. Rodriguez JJ, Montaron MF, Petry KG, Arrousseau C, Marinelli M, Premier S, Rougon G, Le Moal M, Abrous DN. Complex regulation of the expression of the polysialylated form of the neuronal cell adhesion molecule by glucocorticoids in the rat hippocampus. Eur J Neurosci (1998) 10:2994-3006.

  16. Montaron MF, Petry KG, Rodriguez JJ, Marinelli M, Aurousseau C, Rougon G, Le Moal M, Abrous DN. Adrenalectomy increases neurogenesis but not PSA-NCAM expression in aged dentate gyrus. Eur J Neurosci (1999) 11:1479-1485.

  17. Barrot M, Marinelli M, Abrous DN, Rougé-Pont F, Le Moal M, Piazza PV. Functional heterogeneity in dopamine release and in the expression of Fos-like proteins within the rat striatal complex. Eur J Neurosci (1999) 11:1155-1166.

  18. Barrot M, Marinelli M, Abrous DN, Rougé-Pont F, Le Moal M, Piazza PV. The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent. Eur J Neurosci (2000) 12: 973-979.

  19. Marinelli M, White FJ. Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J Neurosci (2000) 20:8876-8885.

  20. Barrot M, Abrous DN, Marinelli M, Rougé-Pont F, Le Moal M, Piazza PV. Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum. Eur J Neurosci (2001) 13:812-818.

  21. Brandon CL, Marinelli M, Baker LK, White FJ. Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats. Neuropsychopharmacology (2001) 25:651-661.

  22. Lu W, Marinelli M, Xu D, Worley PR, Wolf ME. Amphetamine and cocaine do not increase Narp expression in rat ventral tegmental area, nucleus accumbens or prefrontal cortex, but Narp may contribute to individual differences in responding to a novel environment. Eur J Neurosci (2002) 15:2027-2036.

  23. Rougé-Pont F, Mayo W, Marinelli M, Gingras M, Le Moal M, Piazza PV. The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens. Eur J Neurosci (2002) 16:169-173.

  24. Marinelli M, Piazza PV. Interaction between glucocorticoid hormones stress and psychostimulant drugs. Eur J Neurosci (2002) 16:387-394.

  25. Shalev U, Marinelli M, Baumann MN, Piazza PV, Shaham Y. The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking. Psychopharmacology (2003) 168:170-176.

  26. Marinelli M, Cooper DC, Baker L, White FJ. Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior. Psychopharmacology (2003) 168:84-98.

  27. Brandon CL, Marinelli M, White FJ. Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons. Biol Psych (2003) 54:1338-1344.

  28. Mathon DS, Ramakers GM, Pintar JE, Marinelli M. Decreased firing frequency of midbrain dopamine neurons in mice lacking mu opioid receptors. Eur J Neurosci (2005) 21:2883-2886.

  29. Marinelli M, The many facets of the locomotor response to a novel environment test: Theoretical comment on Mitchell et al. (2005). Behav Neurosci (2005) 119:1144-1151. (Commentary)

  30. Marinelli M, Rudick CN, Hu X-T, White FJ. Excitability of dopamine neurons: modulation and physiological consequences. CNS Neuro Disord Drug Targets (2006) 5:79-97.

  31. Cagniard B, Beeler JA, Britt JP, McGehee DS, Marinelli M, Zhuang X. Dopamine scales performance in the absence of new learning. Neuron (2006) 51:541-547.

  32. Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron (2006) 51:801-810.

  33. Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng L-J, Shaham Y, Marinelli M, Wolf ME. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature (2008) 454:118-121.

  34. Geisler S, Marinelli M, DeGarmo B, Becker ML, Freiman AJ, Beales M,. Meredith GE, Zahm DS. Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine.  Neuropsychopharmacology (2008) 33:2688-2670.

  35. Jhou TC, Geisler S, Marinelli M, DeGarmo BA, Zahm DS. The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of tsai and substantia nigra compacta. J Comp Neurol (2009) 513:566–596.

  36. Ambroggi F, Turiault M, Milet A, Deroche-Gamonet V, Parnaudeau S, Balado E, Barik J, van der Veen R, Maroteaux G, Lemberger T, Schütz G, Lazar M, Marinelli M, Piazza PV, Tronche F. Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci (2009) 12:247-249.

  37. McCutcheon JE, Marinelli M. Age matters. Eur J Neurosci (2009) 29:997-1014.

  38. McCutcheon JE, White FJ,  Marinelli M. Individual differences in dopamine cell neuroadaptations following cocaine self-administration. Biol Psych (2009) 66:801-803.

  39. Melis M, Diana M, Enrico P, Marinelli M, Brodie MS. Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress. Alcohol (2009) 43:531-539.

  40. Zahm DS, Becker ML, Freiman AJ, Strauch S, Geisler S, Meredith GE, Marinelli M. Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the basal forebrain and recalibration of expression. Neuropsychopharmacology (2010) 35:445-463.

  41. Steiner H, Van Waes V, Marinelli M. Fluoxetine potentiates methylphenidate-induced gene regulation in addiction-related brain regions: Concerns for use of cognitive enhancers? Biol Psych (2010) 67:592-594.

  42. Conrad KL, Ford KE, Marinelli M, Wolf ME. Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration. Neuroscience (2010) 169:182-194.

  43. Conrad KL, McCutcheon JE, Cotterly LM, Ford KA, Beales M, Marinelli M. Persistent increases in cocaine-seeking behavior after acute exposure to cold swim stress. Biol Psych (2010) 68:303-305.

  44. Van Waes V, Beverley J, Marinelli M, Steiner H. Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum. Eur J Neurosci (2010) 32:435-447.

  45. McCutcheon JE, Wang X, Tseng KY, Wolf ME, Marinelli M. Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. J Neurosci (2011) 31:5737-5743.

  46. McCutcheon JE, Loweth JA, Ford KA, Marinelli M, Wolf ME, Tseng KY. Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism. J Neurosci (2011) 31:14536-14541.

  47. McCutcheon JE, Conrad KL, Carr SB, Ford KA, McGehee DS, Marinelli M. Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults. J Neurophysiol (2012) 108:1620-1630.

  48. Wong WC, Ford KA, Pagels NE, McCutcheon JE, Marinelli M. Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence. J Neurosci (2013) 33:4913-4922.

  49. Wang X, Cahill ME, Werner C, Christoffel D, Golden S, Xie Z, Loweth J, Marinelli M, Russo S, Penzes P, Wolf ME. Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity,enabling incentive sensitization. J Neurosci (2013) 33:11012-11022.

Book Chapters & Research Monographs
  1. Piazza PV, Marinelli M, Rougé-Pont F, Deroche V, Maccari S, Simon H, Le Moal M. Stress, glucocorticoids and mesencephalic dopaminergic neurons: a pathophysiological chain determining vulnerability to psychostimulant abuse. NIDA Monogr Rev (1996) 163: 277-299.

  2. Marinelli M, Cooper DC, White FJ. Electrophysiological correlates of enhanced vulnerability to cocaine self-administration. In: Phenotypic differences in drug effects related to behavioral traits versus states. NIDA Monogr Rev (2001) 181:46-48.

  3. Marinelli M, Piazza PV. Influence of hormonal and environmental factors in the sensitivity to psychostimulants. In: Molecular basis of drug addiction. R. Maldonado (Ed). Humana Press Inc., Totowa, NJ (2003) pp. 133-159.

  4. Marinelli M, Piazza PV. Glucocorticoid hormones, individual differences, and behavioral and dopaminergic responses to psychostimulant drugs. In: Handbook on stress and the Brain. T Steckler, NH Kalin, JMHM Reul (Eds). Elsevier Science, Amsterdam, The Netherlands (2005) Vol 15, pp. 89-111.

  5. Marinelli M. Dopaminergic reward pathways and effects of stress. In: Stress and Addiction: Biological and Psychological Mechanisms. M al’Absi (Ed). Elsevier Science, Amsterdam, The Netherlands (2007) pp. 41-83.

 

 

 

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Last Reviewed: January 29, 2014

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Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


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