My laboratory studies molecular mechanisms that underlie addiction and co-morbid conditions such as anxiety and pain. We have focused on signal transduction pathways that involve the protein kinase C (PKC) family of serine-threonine kinases. In cultured neuronal cell lines, ethanol alters the localization and increases the abundance of two PKC isozymes, PKCdelta and PKCepsilon. In addition, comparative transcriptome analysis has shown that PKCepsilon and PKCzeta are highly expressed in the brains of mice that consume large amounts of ethanol. Therefore, my laboratory is examining PKCdelta, PKCepsilon, and PKCzeta to understand the role of these kinases and their signaling pathways in behavior and to identify targets for development of new therapeutic agents to treat addiction, anxiety, and pain. The techniques we use include gene targeting, RNA interference, and chemical genetics with mutant kinases that utilize ATP analogs.
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.