The broad focus of our research group is to define the molecular pathways that regulate aging and age-related
diseases. In diverse organisms ranging from worms to mammals, the
over-consumption of food dramatically
decreases lifespan and calorie restriction markedly slows the rate of aging. Obesity is caused by a surfeit of nutrients, and is one of the most important pro-aging conditions in the developed world; it shortens lifespan by significantly increasing the risk of type II diabetes, cardiovascular disease, Alzheimer's disease, and numerous cancers. In aggregate, these diseases account for the vast majority of deaths in most nations worldwide. What are the biological mechanisms linking nutrient status and metabolism to this plethora of devastating diseases? To address this question, we largely focus our scientific efforts on mitochondria for two main reasons. First, mitochondria metabolize the vast majority of nutrients that we consume. Second, mitochondrial dysfunction is strongly implicated in virtually every age-related disease. The approaches we use include a combination of genetics, molecular biology, 'omics screens, and biochemical techniques in cells and genetically modified animals. Some examples of research projects we are currently or soon to be working on include the following:
For more information see: Mills Lab
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.