Student Information Training Programs Research Centers

Pharmacology & Toxicology

Research and Graduate Training Faculty


Mills, Edward M., Ph.D.
Associate Professor of Pharm./Tox.
Bergen-Brunswig Fellow
BME 3.510D

Student Support and Grants

Students in my laboratory are supported by a combination of teaching assistantships, training grant appointments, competitive fellowships, and graduate research assistantships.

A. Active Funding (DC = Direct Costs; TC = Total Costs)

R01-DK089224-01A1 (P.I. Mills, 25%) 02/01/2011 to 01/31/2016
"Molecular mechanisms of thermogenesis" $1,250,000 DC; 1,890,000 TC
The goal of this work is to characterize metabolic relevance of a novel thermogenic complex formed by the interaction between uncoupling protein 3 and dienoyl CoA isomerase.

B. Pending Funding

C. Completed Funding

NIHR21DA023684-01 (P.I. Mills, 20%) 05/15/2008 to 05/14/2010
"Mechanisms of MDMA-induced hyperthermia" $371,000
The goal of this research is to use a mouse genetics approach to understand how MDMA increases thermogenesis and activates UCP3 in mice. The anatomy and mechanisms of amphetamine thermogenesis is the focus.

Texas Higher Education Coordinating Board (P.I. Mills, 10%) 05/15/2008 to 05/14/2010
"Reviving respiration in malignant cells as a strategy to attack cancer" $150,000
The goal of this project is to generate mice that express a tetracycline-inducible UCP3 construct in skin (K5-TetOn-UCP3 mice) in order to conduct tumor reversion studies.

NIH R15 DA022712-01 (P.I. Sprague, Co-I Mills, 5%) 04/01/2007 to 03/31/2010
"Hyperthermia: Uncoupling the agony from Ecstasy." $67,500
The goal of this research is to use a rat and muscle cell culture model to explore how nutrients may affect the pharmacodynamic and thermoregulatory response to the sympathomimetic agent MDMA (Ecstasy) or elements involved in its signaling pathway.

NIEHS / NIH Pilot Grant (P.I. E.M. Mills, 20%) 09/01/2004 - 08/31/2005
MD Anderson Center for Research on Environmental Disease $25,000
"The effect of mitochondrial uncoupling on skin tumorigenesis: development of tissue targeted transgenic mice expressing UCP-1 and UCP-3 in skin.

Research Starter Grant: Pharmacology and Toxicology (P.I. E.M. Mills) 1/01/2007 to 12/31/2008
Pharmaceutical Research and Manufacturers of America Foundation $60,000
"Molecular Mechanisms of Hyperthermia"
The goal of this research project is to examine the mechanisms by which amphetamine-type stimulants induce hyperthermia using mouse models.


More information about Dr. Mills
> Publications
> Lab Members
> Lab Alumni
> Research Images
> Lab Photos
> Return to Mills' Home Page

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Last Reviewed: July 7, 2011

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA

Email Address: pharmtox

Phone: 512-471-5158

Parkinson Gene Link May Aid Battle Against Disease

Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.

> Read more about Dr. Mukhopadhyay's research.

Erickson Authors New Book

"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.

> Read more about Dr. Erickson's new book.

Gore receives SEBM award

Andrea Gore is named to the SEBM Distinguished Scientist Award.

> Read more about Dr. Gore's new award.

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