Students in my laboratory are supported by a combination of teaching assistantships, training grant appointments, competitive fellowships, and graduate research assistantships.

A. Active Funding (DC = Direct Costs; TC = Total Costs)

R01-DK089224-01A1 (P.I. Mills, 25%) 02/01/2011 to 01/31/2016
"Molecular mechanisms of thermogenesis" $1,250,000 DC; 1,890,000 TC
The goal of this work is to characterize metabolic relevance of a novel thermogenic complex formed by the interaction between uncoupling protein 3 and dienoyl CoA isomerase.

B. Pending Funding

C. Completed Funding

NIHR21DA023684-01 (P.I. Mills, 20%) 05/15/2008 to 05/14/2010
"Mechanisms of MDMA-induced hyperthermia" $371,000
The goal of this research is to use a mouse genetics approach to understand how MDMA increases thermogenesis and activates UCP3 in mice. The anatomy and mechanisms of amphetamine thermogenesis is the focus.

Texas Higher Education Coordinating Board (P.I. Mills, 10%) 05/15/2008 to 05/14/2010
"Reviving respiration in malignant cells as a strategy to attack cancer" $150,000
The goal of this project is to generate mice that express a tetracycline-inducible UCP3 construct in skin (K5-TetOn-UCP3 mice) in order to conduct tumor reversion studies.

NIH R15 DA022712-01 (P.I. Sprague, Co-I Mills, 5%) 04/01/2007 to 03/31/2010
"Hyperthermia: Uncoupling the agony from Ecstasy." $67,500
The goal of this research is to use a rat and muscle cell culture model to explore how nutrients may affect the pharmacodynamic and thermoregulatory response to the sympathomimetic agent MDMA (Ecstasy) or elements involved in its signaling pathway.

NIEHS / NIH Pilot Grant (P.I. E.M. Mills, 20%) 09/01/2004 - 08/31/2005
MD Anderson Center for Research on Environmental Disease $25,000
"The effect of mitochondrial uncoupling on skin tumorigenesis: development of tissue targeted transgenic mice expressing UCP-1 and UCP-3 in skin.

Research Starter Grant: Pharmacology and Toxicology (P.I. E.M. Mills) 1/01/2007 to 12/31/2008
Pharmaceutical Research and Manufacturers of America Foundation $60,000
"Molecular Mechanisms of Hyperthermia"
The goal of this research project is to examine the mechanisms by which amphetamine-type stimulants induce hyperthermia using mouse models.