Current Lab Members
Back row: Ellen Abramson, Alexander Kenaston Matthew Pfeiffer, Kristin Fathe
Front row: Katsuya Hirasaka, Edward (Ted) Mills, Takeshi Nikawa (Collaborator), Sara Nowinsky, Christine Dao"
Emerging evidence implicates reactive oxygen species (ROS) as important mediators of signal transduction cascades involved in determination of cell fates ranging from apoptosis to differentiation. One barrier towards understanding the functional roles of oxidants is the identification of specific protein targets of oxidation in vivo. My project deals with the orphan nuclear receptor NGFI-B, a steroid/thyroid hormone superfamily transcription factor critical for skeletal muscle development and physiology, and a regulator of apoptosis in cancer cells. I recently discovered that NGFI-B also regulates mitochondrial membrane potential in a manner apparently independent from its roles as a transcription factor.
Matthew Pfeiffer, Ernst-Bernhard Kayser, Xianmei Yang, Ellen Abramson, Monte A. Kenaston, Cory U Lago, Herng-Hsiang Lo, Margaret Sedensky, Adam Lunceford, Catherine Clark, Sarah Wu, Christopher McLeod, Toren Finkel, Philip Morgan, and Edward M Mills. Caenorhabditis elegans UCP4 controls complex II-mediated oxidative phosphorylation through succinate transport (2011) J. Biol. Chem. (Under Review, June 2011).
Mills EM, Weaver KL, Abramson E, Pfeiffer M, Sprague JE (2008) Influence of dietary fats on ecstasy-induced hyperthermia Brit J Pharmacol 151: 1103-1108
Malignant cells display whole scale bioenergetic changes compared to normal cells that are typified by increased glycolysis and decreased mitochondrial oxidative phosphorylation / respiration. Recent evidence suggests that this phenotype promotes the use of mitochondria as biosynthetic machines for cancer cell growth. To better understand the relationships between changes in mitochondrial metabolism and carcinogenesis, our lab generated hemizygous mice expressing a skin-targeted uncoupling protein 3 construct that show increased cutaneous respiration and potent cancer resistance. My project is focused on the mechanisms by which UCP3 antagonizes skin cancer development.
E Abramson; S Nowinski; K Hirasaka; Y Katagiri; G Guroff; Edward M Mills. Redox regulation of the orphan nuclear hormone receptor NGFI-B by thioredoxin 1 (2011) PLoS ONE (Under Review, June 2011).
Heat shock proteins (HSPs) are involved in the cellular response to noxious stimuli such as toxicity, oxidative stress, hyperthermia and inflammation. A recently characterized mitochondrial HSP named cvHSP is expressed most highly in the heart, skeletal muscle, and adipose tissues. My project focuses on exploring the physiological role of HSP with specific emphasis on protein-protein interactions with mitochondrial proteins and its effects on mitochondrial metabolism.
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Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.