Current Lab Members
Shohei Kohno, Ph.D
My projects focus on the role of uncoupling proteins and mitochondrial metabolism in the regulation of muscle physiology and pathology.
Malignant cells display whole scale bioenergetic changes compared to normal cells that are typified by increased glycolysis and decreased mitochondrial oxidative phosphorylation / respiration. Recent evidence suggests that this phenotype promotes the use of mitochondria as biosynthetic machines for cancer cell growth. To better understand the relationships between changes in mitochondrial metabolism and carcinogenesis, our lab generated hemizygous mice expressing a skin-targeted uncoupling protein 3 construct that show increased cutaneous respiration and potent cancer resistance. My project is focused on the mechanisms by which UCP3 antagonizes skin cancer development.
Heat shock proteins (HSPs) are involved in the cellular response to noxious stimuli such as toxicity, oxidative stress, hyperthermia and inflammation. A recently characterized mitochondrial HSP named cvHSP is expressed most highly in the heart, skeletal muscle, and adipose tissues. My project focuses on exploring the physiological role of HSP with specific emphasis on protein-protein interactions with mitochondrial proteins and its effects on mitochondrial metabolism.
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Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.