Student Information Training Programs Research Centers

Pharmacology & Toxicology

Research and Graduate Training Faculty


Mills, Edward M., Ph.D.
Associate Professor of Pharm./Tox.
Bergen-Brunswig Fellow
BME 3.510D

  1. Matthew Pfeiffer, Ernst-Bernhard Kayser, Xianmei Yang, Ellen Abramson, Monte A. Kenaston, Cory U Lago, Herng-Hsiang Lo, Margaret Sedensky, Adam Lunceford, Catherine Clark, Sarah Wu, Christopher McLeod, Toren Finkel, Philip Morgan, and Edward M Mills. Caenorhabditis elegans UCP4 controls complex II-mediated oxidative phosphorylation through succinate transport (2011) J. Biol. Chem. (Under Review, June 2011).

  2. E Abramson; S Nowinski; K Hirasaka; Y Katagiri; G Guroff; Edward M Mills. Redox regulation of the orphan nuclear hormone receptor NGFI-B by thioredoxin 1 (2011) PLoS ONE (Under Review, June 2011).

  3. M. Alexander Kenaston, Katsuya Hirasaka, Kristin Fathe, Sara M Nowinski, Matthew E Pfeiffer, Xianmei Yang, Takeshi Nikawa, and Edward M Mills. IDENTIFICATION OF THE FATTY ACID-SENSITIVE INTERACTION OF MITOCHONDRIAL UNCOUPLING PROTEIN 3 AND Δ3,5Δ2,4 DIENOYL-COA ISOMERASE IN SKELETAL MUSCLE (2011) Diabetes (in final revision, June 2011).

  4. Cory U. Lago, Sara M. Nowinski, Joyce E. Rundhaug, Matthew E. Pfeiffer, Katsuya Hirasaka, M. Alexander Kenaston, Xianmei Yang, Ellen M. Abramson, Shawn B. Bratton, Renata Colavitti, Takeshi Nikawa, Carol Trempus, Susan M. Fischer, and Edward M. Mills. Mitochondrial respiratory uncoupling blocks skin carcinogenesis. J. Biol. Chem. (In final revision, June 2011).

  5. Hirasaka K, Lago CU, Kenaston MA, Fathe K, Nowinski SM, Nikawa T, Mills EM. Identification of a redox-modulatory interaction between uncoupling protein 3 and thioredoxin 2 in the mitochondrial intermembrane space. (2011) Antioxid Redox Signal, [Epub ahead of print]

  6. M. Alexander Kenaston, Ellen Abramson, Matthew Pfeiffer, Edward M. Mills (2009) Chapter 70: Toxicology of Skeletal Muscle General and Applied Toxicology 3rd Ed. Wiley, ISBN 978-470-72327-2

  7. Nikawa T., Hirasaka K., Ishidoh K., Ikemoto M., Kano M., Nonaka I., Ogawa T., Yasui N., Yasutomo K., Adams G. R., Baldwin K. M., Kominami H., Inazu T., Gu H., Takeda S., Mills E. M., Kishi K.  (2009) The ubiquitin ligase Cbl-b is a master regulator of skeletal muscle atrophy during muscle unloading.  Molecular and Cellular Biology 29(17): 4798-4811

  8. Matthew Banks, Candice Gehret, Sarah Buzard, Alexander Kenaston, Edward M. Mills, Jon E. Sprague. (2009) Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis. European Journal of Pharmacology 615(1-3) 257-61.

  9. Wyeth R.P., Mills E. M., Ulman A., Kenaston M.A., Burwell J., Sprague J.E. The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is gender sensitive. Toxicology and Applied Pharmacology 235(1): 33-38.

  10. Hang Wang, Yasuhiro Katagiri, Thomas McCann, Zu-Xi Yu, Fei Tan, Edward Unsworth, Paul Goldsmith, Edward M. Mills, Yu Wang, , Aviva J. Symes, and Herbert M. Geller (2007) 4-sulfation of chondroitin is essential for inhibition of axonal growth. J. Cell Biol. (In review, 3-2008).

  11. Mills E. M., Weaver K. L., Abramson E., Pfeiffer M., and Sprague J. E. (2007). Influences of dietary fats on Ecstasy-induced hyperthermia. Br. J. Pharmacol May 29 [Epub ahead of print].

  12. Sprague J. E., Yang X., and Sommers J., Gillman T.L., Mills E. M. (2007) Roles of plasma norepinephrine, free fatty acids, thyroid hormone and uncoupling protein 3 in sympathomimetic hyperthermia. J. Pharmacol. And Exper. Therapeutics 320: 274-280.

  13. Prabhakaran K., Li L., Mills E.M., Borowitz J.L., Isom G.E. (2005) Up-regulation of UCP-2 by cyanide is linked with cytotoxicity in mesencephalic cells. J. Pharmacol. Exp. Ther. 314(3): 1338-1345.

  14. Rusyniak D.E., Tandy S. L., Hekmatyar N. S., Mills E. M., Smith D. J., Bansal N., Sprague J. E. (2005) Role of mitochondrial uncoupling in MDMA-mediated skeletal muscle hyperthermia and rhabdomyolysis. J. Pharmacol. Exp. Ther. 313(2): 629-639.

  15. Sprague J. E., Moze P., Caden D., Rusyniak D. E., Mills E. M. (2005) Carvedilol rapidly reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy) Crit Care Med 33(6): 1311-1316.

  16. Li L., Prabhakaran K., Mills E. M., Borowitz J. L., Isom G. E. (2005) Uncoupling Protein-2 Switches the Mode of Cyanide-induced Death From Apoptosis to Necrosis In Cortical Cells. Toxicolog. Sci. 86(1): 116-124.

  17. Mills E. M., Rusyniak D. E., Sprague J. E. (2004) Role of uncoupling proteins in sympathomimetic-induced hyperthermia: a focus on 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). J. Mol. Medicine 82(12): 787-99.

  18. (Invited Review) Mills E. M., Rusyniak D. E., Sprague J. E. (2004) Role of uncoupling proteins in sympathomimetic-induced hyperthermia: a focus on 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). J. Mol. Medicine 82(12): 787-99.

  19. Rusyniak D. E., Banks M. L., Mills E. M., Sprague J. E. (2004) Dantrolene use in MDMA (Ecstasy) mediated hyperthermia. Anesthesiology 101(1): 263-264.

  20. Sprague J. E., Smith R. M., Gibbs J., Liu J., Kisor D. F., Mills E. M. (2004) UCP3 and thyroid hormone involvement in methamphetamine-induced hyperthermia. Biochemical Pharmacology 68(7): 1339-43.

  21. Sprague J.E., Brutcher R.E., Mills E. M., Caden D., Rusyniak D.E. (2004) Attenuation of 3,4-methylenedioxymethamphetamine (ecstasy)-induced rhabdomyolysis with alpha1 plus beta3-adrenoceptor antagonists. Br J Pharmacol 142(4): 667-70.

  22. Mills E. M., Banks M. L., Sprague J. E., Finkel T. (2003) Uncoupling the agony from Ecstasy. Nature 426: 403-404.

  23. Sprague J. E., Banks M. L., Cook V. J., and Mills, E. M. (2003) Role of the hypothalamic-pituitary-thyroid (HPT) axis in hyperthermia and neurotoxicity produced by ecstasy (3,4,-methylenedioxymethamphetamine). J. Pharmacol. Exper. Therapeutics, 305(1):159-66.

  24. Mills E. M., Fergusson, M., Combs, C.A., Xu, Y., and Finkel, T. (2002) Regulation of cellular oncosis by uncoupling protein-2. J. Biol. Chem. 277 (30) 27385-92.

  25. Mills E. M., Gunasekar P. G., Li L., Borowitz J. L., and Isom G. E. (1999) Differential susceptibility of brain areas to cyanide involves different modes of cell death. Toxicol. Appl. Pharm. 156, 6-16.

  26. Mills E. M., Takeda K., Yu Z-X., Ferrans V., Katagiri Y., Jiang H., Lavigne M. C., Leto T. L., and Guroff G. (1998) Nerve growth factor treatment prevents the increase in superoxide produced by epidermal growth factor in PC12 cells. Rapid Communication: J. Biol. Chem. 273, 22165-22168.

  27. Bojes H. K., Suresh P. K., Mills E. M., Spitz D. R., Sim J. E., and Kehrer J. P. (1998) Bcl-2 and Bcl-x-L in peroxide-resistant A549 and U87MG cells. Toxicological Sciences 42 (2), 109-116.

  28. Kanthasamy A. G., Ardelt B. K., Mills E. M., Borowitz J. L., and Isom G. E. (1997). Reactive oxygen species generated by cyanide mediate toxicity in rat pheochromocytoma cells. Toxicol. Letters 93 (1) 47-54.

  29. Mills E. M. and Isom G. E. (1996) Chemical hypoxia-induced apoptosis and oxidative stress in differentiated PC12 cells. J. Neurochem. 67 (3) 1039-1046.

Book Chapters

  1. M. Alexander Kenaston, Matthew Pfeiffer, Ellen Abramson and Edward M. Mills. Skeletal Muscle Toxicology. General and Applied Toxicology. 3rd Edition. John Wiley and Sons. In Press, May 2009.
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Last Reviewed: July6, 2011

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA

Email Address: pharmtox

Phone: 512-471-5158

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