Mills, Edward M., Ph.D.
Assistant Professor
PHR 5.218E
512-471-6699
ted_mills@mail.utexas.edu

1. M. Alexander Kenaston, Ellen Abramson, Matthew Pfeiffer, Edward M. Mills (2009) Chapter 70: Toxicology of Skeletal Muscle General and Applied Toxicology 3rd Ed. Wiley, ISBN 978-470-72327-2



2. Nikawa T., Hirasaka K., Ishidoh K., Ikemoto M., Kano M., Nonaka I., Ogawa T., Yasui N., Yasutomo K., Adams G. R., Baldwin K. M., Kominami H., Inazu T., Gu H., Takeda S., Mills E. M., Kishi K.  (2009) The ubiquitin ligase Cbl-b is a master regulator of skeletal muscle atrophy during muscle unloading.  Molecular and Cellular Biology 29(17): 4798-4811



3. Matthew Banks, Candice Gehret, Sarah Buzard, Alexander Kenaston, Edward M. Mills, Jon E. Sprague. (2009) Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis. European Journal of Pharmacology 615(1-3) 257-61.



4. Wyeth R.P., Mills E. M., Ulman A., Kenaston M.A., Burwell J., Sprague J.E. The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is gender sensitive. Toxicology and Applied Pharmacology 235(1): 33-38.



5. Hang Wang, Yasuhiro Katagiri, Thomas McCann, Zu-Xi Yu, Fei Tan, Edward Unsworth, Paul Goldsmith, Edward M. Mills, Yu Wang, , Aviva J. Symes, and Herbert M. Geller (2007) 4-sulfation of chondroitin is essential for inhibition of axonal growth. J. Cell Biol. (In review, 3-2008).



6. Mills E. M., Weaver K. L., Abramson E., Pfeiffer M., and Sprague J. E. (2007). Influences of dietary fats on Ecstasy-induced hyperthermia. Br. J. Pharmacol May 29 [Epub ahead of print].



7. Sprague J. E., Yang X., and Sommers J., Gillman T.L., Mills E. M. (2007) Roles of plasma norepinephrine, free fatty acids, thyroid hormone and uncoupling protein 3 in sympathomimetic hyperthermia. J. Pharmacol. And Exper. Therapeutics 320: 274-280.



8. Prabhakaran K., Li L., Mills E.M., Borowitz J.L., Isom G.E. (2005) Up-regulation of UCP-2 by cyanide is linked with cytotoxicity in mesencephalic cells. J. Pharmacol. Exp. Ther. 314(3): 1338-1345.



9. Rusyniak D.E., Tandy S. L., Hekmatyar N. S., Mills E. M., Smith D. J., Bansal N., Sprague J. E. (2005) Role of mitochondrial uncoupling in MDMA-mediated skeletal muscle hyperthermia and rhabdomyolysis. J. Pharmacol. Exp. Ther. 313(2): 629-639.



10. Sprague J. E., Moze P., Caden D., Rusyniak D. E., Mills E. M. (2005) Carvedilol rapidly reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy) Crit Care Med 33(6): 1311-1316.



11. Li L., Prabhakaran K., Mills E. M., Borowitz J. L., Isom G. E. (2005) Uncoupling Protein-2 Switches the Mode of Cyanide-induced Death From Apoptosis to Necrosis In Cortical Cells. Toxicolog. Sci. 86(1): 116-124.



12. Sprague J.E., Brutcher R.E., Mills E. M., Caden D., Rusyniak D.E. (2004) Attenuation of 3,4-methylenedioxymethamphetamine (ecstasy)-induced rhabdomyolysis with alpha1 plus beta3-adrenoceptor antagonists. Br J Pharmacol 142(4): 667-70.



13. Sprague J. E., Smith R. M., Gibbs J., Liu J., Kisor D. F., Mills E. M. (2004) UCP3 and thyroid hormone involvement in methamphetamine-induced hyperthermia. Biochemical Pharmacology 68(7): 1339-43.



14. Rusyniak D. E., Banks M. L., Mills E. M., Sprague J. E. (2004) Dantrolene use in MDMA (Ecstasy) mediated hyperthermia. Anesthesiology 101(1): 263-264.



15. Mills E. M., Rusyniak D. E., Sprague J. E. (2004) Role of uncoupling proteins in sympathomimetic-induced hyperthermia: a focus on 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). J. Mol. Medicine 82(12): 787-99.



16. Mills E. M., Banks M. L., Sprague J. E., Finkel T. (2003) Uncoupling the agony from Ecstasy. Nature 426: 403-404.



17. Sprague J. E., Banks M. L., Cook V. J., and Mills, E. M. (2003) Role of the hypothalamic-pituitary-thyroid (HPT) axis in hyperthermia and neurotoxicity produced by ecstasy (3,4,-methylenedioxymethamphetamine). J. Pharmacol. Exper. Therapeutics, 305(1):159-66.



18. Mills E. M., Fergusson, M., Combs, C.A., Xu, Y., and Finkel, T. (2002) Regulation of cellular oncosis by uncoupling protein-2. J. Biol. Chem. 277 (30) 27385-92.



19. Mills E. M., Gunasekar P. G., Li L., Borowitz J. L., and Isom G. E. (1999) Differential susceptibility of brain areas to cyanide involves different modes of cell death. Toxicol. Appl. Pharm. 156, 6-16.



20. Mills E. M., Takeda K., Yu Z-X., Ferrans V., Katagiri Y., Jiang H., Lavigne M. C., Leto T. L., and Guroff G. (1998) Nerve growth factor treatment prevents the increase in superoxide produced by epidermal growth factor in PC12 cells. Rapid Communication: J. Biol. Chem. 273, 22165-22168.



21. Kanthasamy A. G., Ardelt B. K., Mills E. M., Borowitz J. L., and Isom G. E. (1997). Reactive oxygen species generated by cyanide mediate toxicity in rat pheochromocytoma cells. Toxicol. Letters 93 (1) 47-54.



22. Bojes H. K., Suresh P. K., Mills E. M., Spitz D. R., Sim J. E., and Kehrer J. P. (1998) Bcl-2 and Bcl-x-L in peroxide-resistant A549 and U87MG cells. Toxicological Sciences 42 (2), 109-116.



23. Mills E. M. and Isom G. E. (1996) Chemical hypoxia-induced apoptosis and oxidative stress in differentiated PC12 cells. J. Neurochem. 67 (3) 1039-1046.