Student Information Training Programs Research Centers

Pharmacology & Toxicology

Research and Graduate Training Faculty

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Mills, Edward M., Ph.D.
Associate Professor of Pharm./Tox.
Bergen-Brunswig Fellow
BME 3.510D
512-471-6699
tedmills@austin.utexas.edu


Peer-Reviewed Publications
  1. Mills E. M. and Isom G. E.  (1996) Chemical hypoxia-induced apoptosis and oxidative stress in differentiated PC12 cells.  J. Neurochem.  67 (3) 1039-1046.
  2. Kanthasamy A. G., Ardelt B. K., Mills E. M., Borowitz J. L., and Isom G. E. (1997).  Reactive oxygen species generated by cyanide mediate toxicity in rat pheochromocytoma cells.  Toxicol. Letters 93 (1)  47-54.
  3. Bojes H. K., Suresh P. K., Mills E. M., Spitz D. R., Sim J. E., and Kehrer J. P. (1998) Bcl-2 and Bcl-x-L in peroxide-resistant A549 and U87MG cells.  Toxicological Sciences  42 (2), 109-116.
  4. Mills E. M., Takeda K., Yu Z-X., Ferrans V., Katagiri Y., Jiang H., Lavigne M. C., Leto T. L., and Guroff G. (1998) Nerve growth factor treatment prevents the increase in superoxide produced by epidermal growth factor in PC12 cells.  Rapid Communication:  J. Biol. Chem. 273, 22165-22168.
  5. Mills E. M., Gunasekar P. G., Li L., Borowitz J. L., and Isom G. E.  (1999) Differential susceptibility of brain areas to cyanide involves different modes of cell death.  Toxicol.  and Appl. Pharm. 156, 6-16.
  6. Mills E. M., Fergusson, M., Combs, C.A., Xu, Y., and Finkel, T. (2002) Regulation of cellular oncosis by uncoupling protein-2.  J. Biol. Chem. 277 (30) 27385-92.
  7. Sprague J. E., Banks M. L., Cook V. J., and Mills, E. M. (2003) Role of the hypothalamic-pituitary-thyroid (HPT) axis in hyperthermia and neurotoxicity produced by ecstasy (3,4,-methylenedioxymethamphetamine).  J. Pharmacol. And Exper. Therapeutics, 305(1):159-66.
  8. Mills E. M., Banks M. L., Sprague J. E., Finkel T. (2003) Uncoupling the agony from Ecstasy.   Nature  426: 403-404.
  9. Sprague J.E., Brutcher R.E., Mills E. M., Caden D., Rusyniak D.E. (2004) Attenuation of 3,4-methylenedioxymethamphetamine (ecstasy)-induced rhabdomyolysis with alpha1 plus beta3-adrenoceptor antagonists. Br J Pharmacol 142(4): 667-70.
  10. Sprague J. E., Smith R. M., Gibbs J., Liu J., Kisor D. F., Mills E. M. (2004) UCP3 and thyroid hormone involvement in methamphetamine-induced hyperthermia.  Biochemical Pharmacology  68(7): 1339-43
  11. Rusyniak D. E., Banks M. L., Mills E. M., Sprague J. E. (2004) Dantrolene use in MDMA (Ecstasy) mediated hyperthermia.  Anesthesiology 101(1): 263-264.
  12. (Invited Review)  Mills E. M., Rusyniak D. E., Sprague J. E.  (2004) Role of uncoupling proteins in sympathomimetic-induced hyperthermia:  a focus on 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy).  J. Mol. Medicine  82(12): 787-99.
  13. Sprague J. E., Moze P., Caden D., Rusyniak D. E., Mills E. M.* (2005) Carvedilol rapidly reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy) Crit Care Med  33(6): 1311-1316.
  14. Li L., Prabhakaran K., Mills E. M., Borowitz J. L., Isom G. E. (2005) Enhancement of Cyanide-induced Mitochondrial Dysfunction and Cortical Cell Necrosis by Uncoupling Protein-2. Toxicolog. Sci.  86(1): 116-124.
  15. Rusyniak D.E., Tandy S. L., Hekmatyar N. S., Mills E. M., Smith D. J., Bansal  N., Sprague J. E. (2005) Role of mitochondrial uncoupling in MDMA-mediated skeletal muscle hyperthermia and rhabdomyolysis.  J. Pharmacol. Exp. Ther.  313(2): 629-639.
  16. K. Prabhakaran, L. Li, E.M. Mills, J.L. Borowitz, Isom G.E. (2005)  Up-regulation of UCP-2 by cyanide is linked with cytotoxicity in mesencephalic cells.  J. Pharmacol. Exp. Ther. 314(3): 1338-1345.
  17. Sprague J.E., Yang X., Summers J., Gilman T., and Mills E.M.* (2007) Roles of norepinephrine, free fatty acids, thyroid status and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis.  J. Pharmacol. Exp. Ther. 320(1): 274-80.
  18. Edward M. Mills, Kara L. Weaver, Ellen Abramson, Matthew Pfeiffer, and Jon E. Sprague  (2007).  Influences of dietary fats on Ecstasy-induced hyperthermia.  In press, Br. J. Pharmacol.
  19. Hang Wang, Yasuhiro Katagiri, Thomas McCann, Zu-Xi Yu, Fei Tan, Edward Unsworth, Paul Goldsmith, Edward M. Mills, Yu Wang, , Aviva J. Symes, and Herbert M. Geller  (2008) 4-sulfation of chondroitin is essential for inhibition of axonal growth.   J. Cell Sci. 121(18).
  20.  Richard P Wyeth, Edward M. Mills, Tracy Ulman, Alexander Kenaston, Johanna Burwell, and Jon E. Sprague.  (2009)  The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is gender sensitive.  Toxicol. Appl. Pharmacol.  15(235).
  21. Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T.  (2009) Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.  Mol Cell Biol. (17):4798-811.
  22. Matthew Banks, Candice Gehret, Sarah Buzard, Alexander Kenaston, Edward M. Mills, Jon E. Sprague. (2009) Pharmacodynamic characterization of insulin on MDMA-induced
    thermogenesis. European J. Pharmacology 615(1-3):257-61.
  23. Hirasaka K, Lago CU, Kenaston MA, Fathe K, Nowinski SM, Nikawa T, Mills EM. (2011) Identification of a redox-modulatory interaction between uncoupling protein 3 and thioredoxin 2 in the mitochondrial intermembrane space. Antioxid Redox Signal, November, 15(10):2645-61
  24. Matthew Pfeiffer, Ernst-Bernhard Kayser, Xianmei Yang, Ellen Abramson, Monte A. Kenaston, Cory U Lago, Herng-Hsiang Lo, Margaret Sedensky, Adam Lunceford, Catherine Clark, Sarah Wu, Christopher McLeod, Toren Finkel, Philip Morgan, and Edward M Mills.  (2011) Caenorhabditis elegans UCP4 controls complex II-mediated oxidative phosphorylation through succinate transport.  J. Biol. Chem. November, 286(43):37712-20.
  25. Hrometz SL, Thatcher KE, Ebert JA, Mills EM, Sprague JE. (2011) Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.  Toxicolog Letters, July, 206(2):234-7.
  26. Cory U. Lago, Sara M. Nowinski, Joyce E. Rundhaug, Matthew E. Pfeiffer, Katsuya Hirasaka, M. Alexander Kenaston, Xianmei Yang, Ellen M. Abramson, Shawn B. Bratton, Renata Colavitti, Takeshi Nikawa, Carol Trempus, Susan M. Fischer, and Edward M. Mills.  (2012) Mitochondrial respiratory uncoupling blocks skin carcinogenesis. Oncogene, Jan 23 epub ahead of print.
  27. Kohno S, Yamashita Y, Abe T, Hirasaka K, Oarada M, Ohno A, Teshima-Kondo S, Higashibata A, Choi I, Mills EM, Okumura Y, Terao J, Nikawa T.  (2012) Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages.  J Appl Physiol. 2012 May;112(10):1773-82.
  28. Abe T, Hirasaka K, Kagawa S, Kohno S, Ochi A, Utsunomiya K, Sakai A, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Maekawa Y, Terao J, Mills EM, Nikawa T.  (2013)  Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.  Diabetes. 2013 Jun;62(6):1957-69.
  29. Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene andrenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. Mol Cell Biol. 2014 Feb;34(4):739-51.
  30. Dr. Sara Nowinski , Ms. Ashley Solmonson , Dr. Joyce Rundhaug , Dr. Okkyung Rho , Ms. Jiyoon Cho , Dr. Cory Lago , Ms. Christine Dao , Prof. Shawn Bratton , Dr. Susan Fischer , Dr. John DiGiovanni, Edward Mills, Ph.D.   Mitochondrial uncoupling links lipid catabolism to inhibition of Akt and cancer resistance.  Submitted May 2014, In revision for Nature Communications, August 2014.
  31. Dao C., Nowinski S.M., and Mills E.M.  The Heat is On: The Molecular Mechanisms of Drug-Induced Hyperthermia.  Invited Review.  In press, January, 2015. Temperature.
  32. M. Alexander Kenaston, Katsuya Hirasaka, Kristin Fathe, Sara M Nowinski, Matthew E Pfeiffer, Xianmei Yang, Israel Muro, Casey Wright, Takeshi Nikawa, and Edward M Mills. (2011) Identification of the fatty acid-sensitive interaction of mitochondrial uncoupling protein 3 and δ3,5δ2,4 dienoyl-coa isomerase in skeletal muscle (In revision for Diabetes, October, 2014).
  33. Katsuya Hirasaka, Edward M. Mills, Chika Ikeda, Marie Haruna, Tasuku Maeda, Tomoki Abe, Shohei Kohno, Sara M. Nowinski, Ayako Ohno, Shigetada Teshima-Kondo, Yuushi Okumura and Takeshi Nikawa. Influx of calcium ion through uncoupling protein 3 into mitochondria is regulated by Hax-1 in muscle. (in revision for The Journal of Biological Chemistry, October 2014).
  34. Ashley Solmonson, Sara M. Nowinski, Joyce E. Rundhaug, Cory U. Lago, Audrey Rasmussen, Makenzie Harris, Steve Hursting, Susan M. Fischer, and Edward M. Mills. Epithelial respiratory uncoupling drives negative energy balance and antagonizes obesity & insulin resistance. (in preparation for Cell Metabolism, February, 2015).

Book Chapters

  1. M. Alexander Kenaston, Matthew Pfeiffer, Ellen Abramson and Edward M. Mills. Skeletal Muscle Toxicology. General and Applied Toxicology. 3rd Edition. John Wiley and Sons. In Press, May 2009.
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Last Reviewed: January 28, 2015

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


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