Professor
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Mail Code: A1915 |
Office phone (512)471-1911
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Personal Pages: Dr. Morrisett's CV
Research Interests:
My primary research interests center upon the role of amino-acid derived neurotransmitter systems and synaptic transmission in alterations that in underlie a variety of forms of neural functioning and pathologies. These include synaptic changes that occur during the induction and expression of alcohol-related disorders, learning and memory, neuronal development and the development of epilepsy. Major techniques in use in my lab include virtually all in vitro electrophysiological measures in use in neuroscience today (from extracellular recordings of synaptic plasticity to patch clamp recording of quantal synaptic currents). Another faculty in my group, Regina Maldve, PhD, oversees the protein and molecular techniques in our research program and focuses upon kinase-dependent alterations underlying ethanol neuroadaptation in amygdala structures.
Affiliations and Honors:
-Associate Professor, Division of Pharmacology and Toxicology, College of
Pharmacy, University of Texas at Austin, 1997-present.
-Member of the Institute for Neuroscience, University of Texas at Austin, 1997-present.
-Adjunct Associate Professor, Section of Neurobiology, School of Biological
Sciences, University of Texas at Austin, 1999-present.
-National Institutes of Alcohol Abuse and Alcoholism (NIAAA) ALTX-3 regular
study section member, 1998-present.
-1996 Young Investigator Award, University of Nebraska College of Medicine.
-1994 Young Investigator Award, Research Society for Alcoholism.
-1998 Editorial Review Board, Journal of Pharmacology and Experimental Therapeutics
Representative Publications:
Hendricson, A.W., Maldve, R.E., Zhang, T.A., Diaz, L.M., Han, Y., Morrisett, R.A. Aberrant synaptic activation of NMDA receptors underlies ethanol withdrawal hyperexcitability, J Pharmacol Exp Therap, under revision.
Zhang, T.A., Wilkemeyer, M.F., Lippmann, M.J., Charness, M.E., Morrisett, R.A. Synergistic effects of peptide fragment NAPVSIPQ on ethanol inhibition of synaptic plasticity in rat hippocampus,Neuroscience 134:583-93, 2005.
Zhang T.A., Hendricson, A.W., Morrisett, R.A. Dual synaptic sites of D1-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens. Synapse 58:30-44, 2005.
Maldve, R.E., Chen, X., Zhang, T.A., Morrisett, R.A. Ethanol selectively inhibits enhanced vesicular release at excitatory synapses: Real-time visualization in intact hippocampal slices. Alcoholism: Clinical Experimental Research 28:143-152, 2004.
Hendricson, A.H., Sibbald J.R., Morrisett, R.A. Ethanol alters the frequency, amplitude, and decay kinetics of Sr2+-supported, asynchronous NMDAR mEPSCs in rat hippocampal slices. J Neurophysiology 91:2568-2577, 2004.
Diaz, L.M., Maiya, R., Sullivan, M.A., Han, Y., Walton H.A., Boehm S.L. II, Bergeson S.E., Mayfield R.D., Morrisett R.A. Sindbis viral-mediated expression of eGFP-dopamine D1 receptorsin situ with real-time two-photon microscopic detection. J Neuroscience Methods 139:25-31, 2004.
Hendricson, A.W., Thomas, M.P., Lippmann, M.P., Morrisett, R.A. Suppression of L-type voltage-gated calcium channel dependent synaptic plasticity by ethanol: Analysis of miniature synaptic currents and dendritic calcium transients.J Pharmacology Experimental Therapeutics 307:550-558, 2003.
Maldve
RE, Zhang TA, Ferrani-Kile K, Schreiber SS, Lippmann MJ, Snyder GL, Fienberg
AA, Leslie SW, Gonzales RA, Morrisett RA.
DARPP-32 and regulation of the
ethanol sensitivity of NMDA receptors in the nucleus accumbens, Nature Neuroscience,
5: 641-648, 2002. (pdf)
Harris
RA, Morrisett RA.
Two-shot
cocktail: Adenosine, dopamine and a twist of
βγ. Nature Medicine, 8:777-779, 2002. (pdf)
Hendricson
AW, Miao CLA, Lippmann MJ, Morrisett R.A. Ifenprodil and ethanol enhance
NMDA receptor-dependent long-term depression. J. Pharmacol. Exp. Ther.,
301: 938-944, 2002. (pdf)
Thomas M.P. and Morrisett R.A. Dynamics
of NMDAR-mediated neurotoxicity
during chronic ethanol exposure and withdrawal, Neuropharmacology, 39:218-226,2000.
(pdf)
Lewohl
J.M., Wilson W.R., Mayfield, R.D., Brozowski, S.J., Morrisett, R.A. and
Harris, R.A. G-protein-coupled inwardly rectifying potassium channels: Targets
of ethanol action. Nature Neuroscience, 2:1084-90, 1999.(pdf)
Morrisett, R.A. and Thomas, M.P. Of Mice and Minis: Novel forms and analyses
of ethanol effects on synaptic transmission. In: The Drunken Synapse, Y.
Liu and W.A. Hunt., eds., Plenum Press, 1999.
Thomas, M.P., Webster, W.W., Norgren R.B, Monaghan D.T., Morrisett, R.A.
Survival and functional demonstration of interregional pathways in fore/midbrain
slice explant cultures, Neuroscience 85: 615-626 , 1998.
Thomas, M.P., Davis, M.I., Monaghan, D.T., Morrisett, R.A. Organotypic brain
slice cultures for functional analysis of alcohol-related disorders: Novel
versus conventional preparations. Alcoholism: Clinical Exp. Res. 22: 51-59,
1998.
Thomas,
M.P., Monaghan D.T., Morrisett, R.A.
Evidence for a causative role of NMDA
receptors in an in vitro model of alcohol withdrawal hyperexcitability.
J. Pharmacol. Exp. Therap. 287: 87-97, 1998. (pdf)
Morrisett R.A. Electrophysiologic characteristics of Heteromeric Recombinant
NMDA receptors.: Comparison with native receptors. In: The Ionotropic Glutamate
Receptors, R. Wenthold, D. Monaghan (eds.), Humana Press, NY, 1996.
Zheng J., Morrisett R.A., Jianhua Zhu and Hexum, T.D. Neuropeptide Y (18-36)
modulates chromaffin cell catecholamine secretion by blocking the nicotinic
receptor ion channel. J. Pharmacol. Exp. Therap. 274: 891-897, 1995.
Buller A.L., Morrisett, R.A. and Monaghan, D.T. Glycine modulates ethanol
inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus
oocytes. Mol. Pharmacol. 48: 717-723, 1995.
Buller, A.L., Clark, H.C., Schneider, B.J., Morrisett, R.A., Monaghan, D.T.
Anatomical and pharmacological properties of NMDA receptor subtypes: Native
pharmacology predicted by subunit composition. J. Neuroscience 14: 5471-5484,
1994.
Morrisett, R.A., Swartzwelder, H.S. Attenuation of hippocampal long-term
potentiation by ethanol: A patch clamp analysis of glutamatergic and GABAergic
mechanisms. J. Neuroscience 13: 2264-2272, 1993.
Hosford, D., Clark, S., Cao Z., Wilson, W.A., Lin, F-H., Morrisett, R.A.,
Huin, A. Activation of GABAB receptors in lethargic mice with absence seizures.
Science 257: 398-401, 1992.
Xie, C.W., Morrisett, R.A., Lewis, D.V. Mu opiod receptor-mediated modulation
of synaptic currents in dentate granule cells of rat hippocampus. J. Neurophysiology
68: 1113-1120 (1992).
Morrisett, R.A., Mott, D.O., Lewis, D.V., Swartzwelder, H.S., Wilson, W.A.
GABAB-mediated inhibition of the NMDA component of synaptic transmission
in area CA1 of rat hippocampus. J. Neuroscience 11: 203-209 (1991).
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