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Adam W. Hendricson, Ph.D.
Post-Doctoral Fellow
The Division of Pharmacology/Toxicology of the College of Pharmacy and
The Waggoner Center for Alcohol and Substance Abuse Research at
The University of Texas at Austin
Mail to:
The University of Texas at Austin
PHAR-Pharmacology
1 University Station A1915
Austin, TX. 78712-0125
H: 512-371-3350
W: 512-471-1018
fax: 512-475-6088
Email: ahendricson@mail.utexas.edu
Doctor of Philosophy, 2002, Pharmacology
Tulane University School of Medicine
New Orleans, LA.
Bachelor of Science, 1997, Psychobiology
Tulane University School of Medicine
New Orleans, LA.
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Description of Present Research:
The present line of inquiry focuses exclusively on the role of NMDA receptors
(NMDARs) in triggering electrographic ethanol withdrawal seizures, a prime cause
of morbidity and mortality in chronic ethanol abusers. Using the hippocampal
blind slice patch-clamp preparation, recordings of pharmacologically isolated
NMDAR-mediated miniature synaptic events (mEPSCs) will be made from organotypic
hippocampal tissue cultures (explants) in the setting of chronic ethanol administration,
and at various time-points after withdrawal of ethanol. Withdrawal-induced changes
in NMDAR-mediated signaling will be temporally correlated with the onset of
electrographic seizures detected via field potential monitoring of hippocampal
discharge patterns. Confocal imaging of GFP-tagged NMDARs expressed by explanted
hippocampal neurons will be employed to directly visualize chronic ethanol-induced
NMDAR trafficking, and to monitor time-dependent changes in NMDAR expression
at various time points following ethanol withdrawal.
Honors, Awards, and Societies
Undergraduate
- Founder's Scholarship, Tulane University, 1993-1997
- National Dean's List Honor Society, 1995
- NSF Research for Undergraduates (REU) Fellowship, 1995 Award # IBN-9021447
- Honors Graduate, Paul Tulane College, 1997
Graduate and post-graduate
- Pharmaceutical Research and Manufacturer's (PhRMA) Foundation Advanced Predoctoral
Fellowship in Basic Pharmacology, 1999-2001.
- NRSA Individual Post-Doctoral Fellowship 1 F32 AA14068-01
- 2002 Research Society on Alcoholism Junior Investigator Award (travel award
to annual
meeting)
- Member, Research Society on Alcoholism
- Member, Biophysical Society
Representative Publications:
Hendricson, A.W., Miao, A.C.L., Lippman, M.J., and Morrisett, R.A. (2002).
Ifenprodil and ethanol enhance NMDA-receptor dependent long term depression.
Journal of Pharmacology and Experimental Therapeutics, 301(3):938-44.
Hendricson, A.W., and Guth, P.S. (2002). Transmitter release from vestibular
hair cells via mGluRs: A role for intracellular Ca++ release. Hearing Research,
172(1-2):99-109.
Hendricson, A.W., and Guth, P.S. (2002). Signal discrimination in the
semicircular canals: A role for group I mGluRs. NeuroReport, 13(14):1765-8.
Fader, A.J., Hendricson, A.W., and Dohanich, G.P. (1997). The effects
of estrogen on spatial learning. Neurobiology of Learning and Memory,
69(3), 225-240.
Hendricson, A.W., and Morrisett, R.A. Dose-dependent discrimination
between pre- and post-synaptic effects of ethanol on Sr++-supported NMDA mEPSCs
in hippocampus, In Preparation.