Morrisett, Richard, Ph.D.
Professor
Revco Foundation Fellow
PHR 5.210A
512-471-1911
ramorris@mail.utexas.edu

PERSONAL DATA:

Professional Address Division of Pharmacology and Toxicology

College of Pharmacy

The University of Texas at Austin

Austin, TX

PH: 512-471-1911

FAX: 512-475-6088

ramorris@mail.utexas.edu

Mailing address: The University of Texas at Austin

PHAR-Pharmacology

1 University Station, A1915

Austin, TX 78712-0125

DEA Licensure Schedule II, II III, IIIN N and IV (renewed 3/06)

EDUCATION:

7/82 - 12/86 University of Alabama at Birmingham

School of Medicine

Department of Pharmacology

Ph.D. in Pharmacology (Award Date: 3/22/1987)

R.S. Jope, Ph.D., preceptor

Dissertation Title: The Effects of Lithium on Cholinergic Activity and Characterization of the Proconvulsive Action of Lithium in Combination with Cholinergic Agonists

9/78 - 5/82 Hampden-Sydney College

Hampden-Sydney, VA

B.S., Chemistry, 1982

PROFESSIONAL EMPLOYMENT:

9/06 - present Professor

Division of Pharmacology and Toxicology

College of Pharmacy and

The Institute for Neuroscience

The University of Texas at Austin

8/97 � 8/06 Associate Professor (with tenure)

Division of Pharmacology and Toxicology

College of Pharmacy and

The Institute for Neuroscience

The University of Texas at Austin

2/99 - present Member

Section of Neurobiology

School of Biological Sciences

The University of Texas at Austin

7/98 - present Member

Waggoner Center for Alcohol and Addiction Research

The University of Texas at Austin

12/02 - present Member

Institute for Cellular and Molecular Biology

The University of Texas at Austin

7/97 - 8/97 Associate Professor (with tenure)

Department of Pharmacology

University of Nebraska Medical Center

7/91 - 7/97 Assistant Professor

Department of Pharmacology

University of Nebraska Medical Center

9/90 - 7/91 Assistant Medical Research Professor

Department of Medicine (Neurology)

Duke University Medical Center and

The Neurobiology Research Center

6/88 - 9/90 Research Associate

Department of Medicine (Neurology)

Duke University Medical Center and

The Neurobiology Research Center

W.A. Wilson, Ph.D., Director

Veterans Administration Medical Center

PROFESSIONAL EMPLOYMENT: (cont.)

1/87 - 6/88 Research Associate

Department of Medicine (Neurology)

Duke University Medical Center and

Epilepsy Research Center

J.O. McNamara, M.D., Director

Veterans Administration Medical Center

SCIENTIFIC MEMBERSHIPS:

1983 - present Sigma Xi

1987 - present Society for Neuroscience

1991 - present Research Society on Alcoholism

1996 - present American Society for Pharmacology and Experimental Therapeutics

AWARDS:

1. 1994 Young Investigator Award, Research Society on Alcoholism.

2. 1996 Young Investigator Award, University of Nebraska College of Medicine.

3. First Prize, 1985 National Pharmacology Essay Award, Boehinger Ingelheim Centennial Celebration.

4. Revco Foundation Fellowship in Pharmacology, 2004-present

EDITORIAL POSITIONS:

Associate Editor, Journal of Pharmacology and Experimental Therapeutics,
2005-present.

Editorial Advisory Board, Journal of Pharmacology and Experimental Therapeutics, 1998-2005.

Editorial Advisory Board, Biochemical Pharmacology, 2004-present.

AD HOC JOURNAL REVIEWS:

Alcoholism: Clinical Experimental Research

Alcohol

Biochemical Pharmacology

Brain Research

British Journal of Pharmacology

Journal of the American Medical Association (JAMA)

Journal of Applied Pharmacology and Toxicology

Journal of Neurochemistry

Journal of Neurophysiology

Journal of Neuroscience

Life Sciences

Neuroscience Letters

Neuropharmacology

Proceedings of the National Academy of Sciences (PNAS)

Synapse

Toxicology Letters

Journal of Neuroscience Methods

GRANT REVIEWS:

1. National Institute on Alcohol Abuse and Alcoholism (NIAAA) ALTX-3 regular study section member, 1997-2001.

2. NIAAA various special and regular ad hoc Grant Review Committees, 1994-present.

3. Veterans Administration Merit Review Grant Program (Ad hoc), 1991-present.

4. The Wellcome Trust, 1999.

5. The Alzheimer's Association, 1999.

6. American Heart Foundation, Nebraska affiliate, Student Research Fellowship reviewer, 1995.

7. UNMC Seed Grant Review Committee, 1994-1997.

GRANTS/FELLOWSHIPS AWARDED:

ACTIVE:

NIAAA, R01AA015167-01 (Morrisett, PI) 5/05�4/08.
Ethanol, dependence and mesolimbic plasticity

$625,000 (TDC to RAM over 3 years)
This proposal investigates dopamine, DARPP-32 and glutamatergic interactions underlying synaptic alterations in ethanol dependence.

Jones Graduate Fellowship, 2005-2008.
This Waggoner Center for Alcohol and Addiction Research fellowship was awarded to a graduate student in my lab, Jon Theile.

NIAAA, R01AA14874-01 (Gonzales, PI; Morrisett, Co-Inv) 8/04-7/09.
$98,900 (TDC per year to RAM over 5 years)
Mu opiate receptors and ethanol/dopamine interactions
This proposal investigates the molecular and synaptic mechanisms underlying the clinical efficacy of naltrexone in the regulation of VTA-DA release and alcohol dependence.

NIAAA, U01AA13497-01, (Alcantara, PI; Morrisett, Co-Inv), 9/01-8/06.
$42,872 (TDC per year to RAM for 5 years)
Ethanol driven neuroadaptation of cholinergic interneurons
This is an INIA-WEST component designed to assess the alterations in GLU and DA receptor trafficking in the extended amygdala in response to ethanol exposure and in ethanol-preferring animals.

GRANTS/FELLOWSHIPS AWARDED: (cont.)

NIAAA, R01AA09230-09 (Morrisett, PI), 8/1/92-3/05, renewal 4/1/01-3/31/06
$781,817 (TDC over 4 yrs)
Ethanol exposure and hippocampal electrographic seizures
This R01 is continued from my FIRST award and is directed at understanding the synaptic basis for alcohol withdrawal seizures with a focus upon NMDA receptors.

COMPLETED:

NIAAA F31AA14307-01, (Morrisett, mentor)
3/03-2/05, $64,164 (TDC over 2 yrs)
The effect of ethanol on dopamine receptor trafficking in explants
This individual NRSA was awarded to a graduate student in my lab, Laurea Diaz.

NIAAA F32AA14068-01, (Morrisett, mentor), 3/03-2/05, $128,724 (TDC over 2 yrs)
NMDA receptors and ethanol withdrawal seizures
This individual NRSA was awarded to a post-doctoral student in my lab, Adam Hendricson.

Jones Graduate Fellowship, 2002-2005.
This Waggoner Center for Alcohol and Addiction Research fellowship was awarded to a graduate student in my lab, Tao Zhang.

2002 University of Texas undergraduate fellowship (Morrisett, mentor) to Selena Schreiber, $1,000.

2001 University of Texas undergraduate fellowship (Morrisett, mentor) to Heather Scott, $1,000.

Texas Commission on Alcohol and Drug Abuse (Maldve, PI; Morrisett, Co-Inv)
9/02-8/03, $50,000
CDK5 and ethanol of presynaptic function in the NAc
This is a small grant to investigate the involvement of CDK5 in ethanol-induced alterations in neurotransmitter release.

NIAAA, R01AA11845 (Morrisett, PI), 8/1/97-7/31/01, $636,542 (TDC over 4 yrs)
Mechanisms of ethanol effects on synaptic transmission
The major goals of this project were to assess ethanol effects on AMPAR-mediated synaptic transmission and effects on novel forms of non-NMDA receptor dependent forms (VGCC mediated) synaptic potentiation.

Texas Commission on Alcohol and Drug Abuse, (Morrisett, PI),
9/99-8/00; $397,000
A laser core facility for multi-photon fluorescence imaging
The major goal is to support the construction of a core facility utilizing argon and titanium:sapphire lasers for standard confocal and multi-photon fluorescence imaging at two microscope stations and to develop laser-induced fluorescence detection for capillary electrophoresis at a third station in collaboration with Dr. Rueben Gonzales.

GRANTS/FELLOWSHIPS AWARDED: (cont.)

Texas Commission on Alcohol and Drug Abuse (Morrisett, PI), 9/99-8/01, $150,000
Ethanol and synaptic information processing
The major goals include the development and expansion of projects on nAChRs, GIRK and DARPP32 interactions in ethanol modulation of synaptic transmission.

NINDS, R01NS37849 (Monaghan, PI; Morrisett, Co-Inv),
4/1/99-3/31/03, $79,500 (TDC over 4 yrs to RAM)
Growth factor signal transduction and neurotransmission
The major goals of this subcontract project are to assess mechanisms of insulin-receptor mediated potentiation of the NMDAR-component of synaptic transmission.

Texas Commission on Alcohol and Drug Abuse (Shear, PI; Morrisett, Co-Inv)
9/02-8/03, $50,000
Characterization of ethanol pathways in the NAc using localized cytosolic perturbations
This is a small grant to investigate a novel microparticle-perturbation technique for analysis of ethanol effects on dopaminergic signaling in the nucleus accumbens.

Alcoholic Beverage Medical Research Foundation Grant (Morrisett, PI), 1992-1993, $80,000 (TDC over 2 yrs)
Mechanism of ethanol inhibition of physiologically-evoked NMDA synaptic currents

UNMC Seed Grant (Morrisett, PI), 1992-1993, $9,700
Patch clamp recording of NMDAR1 currents in transfected cells

UNMC Collaborative Seed Grant (Morrisett, PI), 1995-1996, $1,000
Mechanisms of HIV-1 neurotoxicity

North Carolina Alcoholism Research Authority Grant (Morrisett, PI), 1990-1991, $25,000 (TDC), Ethanol preference and hippocampal excitatory synaptic transmission

National Research Service Award, NIMH Training Grant, Everett Ellinwood, M.D., Department of Medicine (Psychiatry), Duke University Medical Center, program director. 7/89-6/91.

PENDING:

NIAAA, R01AA09320-10 (Morrisett, PI), TDC $1,250,000

Ethanol exposure and hippocampal electrographic seizures

This is a competing renewal elucidating the molecular and synaptic basis for alcohol withdrawal seizures using the hippocampal organotypic explant model system.

PROFESSIONAL SERVICE:

Research Society on Alcoholism, Program Committee, 2003

College of Pharmacy, University of Texas

Curriculum Committee, 1999-present

Doctor of Pharmacy Admissions Committee, 1997

Financial Aid Committee, 1998-2001

All-College Seminar, 1998-2000

Library Services, 1998-2000

Admissions interviews, 2001-present

Committee on Committees, 2004-present

Post-tenure review committee, 2006-present

Institute for Neuroscience, University of Texas

Chair, Curriculum Committee, 2002-present

Chair, Qualifying Examination Committee, 2004-present

Member, Teaching Assistant and Student Finance Committee, 2005-present

Institute for Cellular and Molecular Biology, University of Texas

International Student Admissions Committee, 2004-present

University of Texas, Review Committee for University Continuing Fellowships,

Dr. J. Dollard, Vice Provost and Dean of Graduate Studies, 2000-2003

University of Texas, Office of Public Affairs, University expert, 2000-present

University of Nebraska, Graduate Faculty Member and Fellow, 1993-1997.

University of Nebraska Medical Center, College of Medicine, Department of Pharmacology

Seminar Committee, Director, 1993-1995

Equipment Committee, Director, 1995-1997

University of Nebraska Medical Center, College of Medicine

Strategic Planning Subcommittee: Faculty Recruitment, Development and Reward Subcommittee, 1994

Medical Student Admissions Committee, 1996

POST-DOCTORAL STUDENTS AND RESEARCH ASSOCIATES:

1. Mark Thomas, Ph.D., Post-doctoral trainee/Research Assoc., May 1994-July 1998. Presently Assistant Professor, Univ. Nebraska Med. Ctr.

2. Walter Wilson, Ph.D. Post-doctoral trainee, 1998-1999.

3. Karima Ferrani-Kile, Ph.D., Post-doctoral trainee, 1998-1999.

4. Adam Hendricson, Ph.D., Post-doctoral trainee, 2001�2005. Presently Research Scientist in drug discovery, Neuromed Corp., Vancouver, B.C.

5. Xiaochun Chen, Ph.D., Post-doctoral trainee, 2001-2002. Presently Research Assoc., Immunology, Johns Hopkins School of Medicine.

GRADUATE STUDENTS MENTORED:

1. Laurea Diaz, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Ph.D. awarded May, 5, 2005.

2. Tao Zhang, in candidacy, Institute for Neuroscience, University of Texas, 2000-present, PhD awarded July 22, 2005

3. Jon Theile, Institute for Cellular and Molecular Biology, University of Texas, 2005-present.

4. Zach Jeanes, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, 2006-present.

GRADUATE STUDENT COMMITTEE SERVICE:

1. Zhi Xu, Department of Physiology, University of Nebraska Medical Center, Ph.D. awarded 1997.

2. Donita Robinson, Institute for Neuroscience, University of Texas, Ph.D. awarded 2000.

3. Erik Wilker, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Ph.D. awarded 2001.

4. Mike Okerberg, Department of Chemistry, University of Texas, Ph.D. awarded 2002.

5. Julie Kern, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Ph.D. awarded 2002.

6. Amanda Tang, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Ph.D. awarded 2003.

7. Janine Mauzeroll, Department of Chemistry, University of Texas, Ph.D. awarded 2004.

8. Yamini Chandrasekaran, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, PhD awarded 2005.

9. WIlliam Doyon, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, PhD awarded 2005.

10. Manoranjan D'Souza, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, in candidacy, 2001-present.

11. Kerrie Hall, Institute for Neuroscience, University of Texas, in candidacy, 2002-present.

12. Mike Roberts, Institute for Cellular and Molecular Biology, University of Texas, in candidacy, 2002-present.

13. Paul Mathews, Institute for Neuroscience, University of Texas, in candidacy, 2004-present.

CONCURRENT AWARDS TO STUDENTS:

Adam Hendricson, PhD

1. Individual Post-Doctoral National Research Service Fellowship Award,
1 F32 AA14068-01, 2003-05.

2. Research Society on Alcoholism Junior Investigator Travel Award 2002-03.

3. Society for Neuroscience Chapters/Burroughs Wellcome Fund,
Postdoctoral Award, 2004.

Laurea Diaz, PhD.

1. Individual Pre-doctoral National Research Service Fellowship Award,
1 F31 AA014307, 2003-05.

2. UT Pharmacy Graduate Student Association Travel Award, 2003, 2004.

3. Research Society on Alcoholism Student Merit Awards, 2003, 2004.

4. UT Fellowship in Addiction Biology, 2003, 2004.

5. UT David J Bruton Fellowship, 2003.

6. UT Jaime Delgado Fellowship, 2004.

7. Enoch Gordis Finalist, 2005 Research Society on Alcoholism annual meeting, Santa Barbara, CA.

Tao Zhang

1. F.M. Jones and H.L. Bruce Endowed Graduate Fellowships in Addiction Biology, the University of Texas at Austin, 2003-05.

2. Jones Travel Award from Waggoner Center for Alcohol and Addiction Research, UT Austin, 2004-05.

3. Research Society on Alcoholism Student travel award, 2002-04.

4. Professional Development Award, UT Austin, 2003.

TEACHING:

University of Texas, College of Pharmacy/Institute for Neuroscience:

1. Neuroscience 382T, Principles of Neuroscience, Fall semester of core curriculum for the Institute for Neuroscience (NEU/PSY/KYN/PHR382T), Course Director, 1998-2001.

2. PHR 189Q, Seminar in Alcohol Studies, Course Director, 2001-present.

3. Neuroscience 382T, Principles of Neuroscience, 28 contact hours. Synaptic transmission, ion channel structure, learning and memory, Lecturer, 1997-2002.

4. Pharmacology 483D, Neuropharmacology, 6 contact hours. Electrophysiologic methods in neuropharmacology, cholinergic neuropharmacology, GABAergic neuropharmacology, Lecturer.

5. PHR 565F, Pharmacotherapteutics IB, 5-7 contact hours. Antiarrhythmic agents, Lecturer, 1998-present.

6. Pharmacotherapteutics IB lab, 1998, 2000.

7. PHR 380F, Biomedical Pharmacology, 4.5 contact hours, CNS depressants, antispasmodics, Lecturer, 2001-present. Course director, 2005-present.

8. PHR 285F, Pharmacotherapeutics IIIB, 3 contact hours. Anesthetics, muscle relaxants, Lecturer, 2002-present.

University of Nebraska Medical Center (College of Medicine):

1. Medical Pharmacology 615-6/815-6, small group facilitator, 1992-1994.

2. Pharmacology 901, Voltage-gated ion channels, Lecturer, 1992.

3. Pharmacology 922, Basic neurophysiology, learning and memory, Course Co-director, 1992 -1997.

4. Pharmacology 307, Antiarrhythmia drugs and digitalis, Lecturer, 1993.

5. Pharmacology 270, Antiarrhythmic drugs, Lecturer, 1993-1997 (spring, fall).

6. Pharmacology 615-6/815-6, Antiarrhythmia drugs and digitalis (5 hrs); Electrolytes, pH and volume control (1 hr), Lecturer, 1993-1996.

Duke University Medical Center:

1. Department of Psychology, Excitatory amino acids and neuronal plasticity, 3 contact hours, Neurobiology of learning and memory, Lecturer, 1989-1990.

2. Department of Pharmacology, Cholinergic neuropharmacology; General neuropharmacology, Lecturer, 1990.

University of Alabama at Birmingham

1. School of Medicine/Dentistry, Department of Pharmacology, Tutor, Medical Pharmacology, 1983-1986, tutored approximately 15 students per year.

INVITED LECTURES, SYMPOSIA, PRESENTATIONS AND PRESS REPORTS:

Hippocampal Plasticity and Prenatal Ethanol Exposure, Dept. of Pharmacology, University of New Mexico School of Medicine, Albuquerque, NM, June 9, 1989.

GABAergic Regulation of Hippocampal Excitability, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, July 17, 1990.

The Role of GABAB Receptors in Neuronal Function, Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS, December 10, 1990.

Regulation of Neuronal Plasticity: GABAB Inhibition of NMDA Function, Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE, January 31, 1991.

Regulation of Excitatory Synaptic Transmission: Role of GABAB Receptors, Proctor and Gamble, Miami Valley Laboratory, Cincinnati, OH, February 1, 1991.

Ethanol, NMDA Receptors and Neuronal Plasticity, Department of Psychology, University of California at Riverside, Riverside, CA, February 14, 1991.

Ethanol Reduces N-Methyl-D-Aspartate Mediated Hyperexcitability Induced by a Priming Paradigm in Rat Dentate Gyrus, Short symposium, Research Society on Alcoholism Annual Meeting, Marco Island, FL, June 1991.

Hippocampal Electrophysiology and Ethanol Exposure, Department of Anatomy, University of Nebraska Medical Center, Omaha, NE, March 16, 1992.

Effect of Prenatal Ethanol Exposure on Hippocampal NMDA Receptors and Magnesium Regulation of NMDA Receptor Function, Short Symposium, Research Society on Alcoholism Annual Meeting, San Diego, CA, June, 1992.

Selective effects of in vitro ethanol exposure and withdrawal on NMDA receptor-mediated epileptiform discharges in dentate gyrus, workshop presentation, Research Society on Alcoholism Meeting, San Antonio, TX, June 1993.

Society for Neuroscience, National Press Release, "New Finding Explains How Alcohol Use Impairs Learning And Memory," May 5, 1993.

USA Today article, "Alcohol Nips Memory and Learning," Page 1, May 10, 1993.

Omaha World-Herald Article, "NU Researcher Shows How Alcohol Affects Brain" (by Mary McGrath), May 13, 1993.

INVITED LECTURES, SYMPOSIA AND PRESENTATIONS: (cont.)

I Came, I Drank, I Forgot: Synaptic Mechanisms of Ethanol Effects on Learning and Memory, Alcohol Research Center, VA Medical Center, Omaha, NE, October 22, 1993.

Synaptic Plasticity and Ethanol Exposure, Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, February 9, 1994.

Invited symposium presentation, The Contribution of NMDA Receptors to Neuronal Hyperexcitability Following Withdrawal from Acute and Chronic Ethanol Exposure, 1994 Research Society on Alcoholism Meeting, Maui, HI, June 22, 1994.

Invited Presenter for NIAAA Workshop: Ethanol and NMDA Receptors: In vitro section, May 1995, Washington, D.C.

Delirium Tremens in a Dish: Modeling the Ethanol Withdrawal Reaction, VA Research Conference, Omaha, NE, May 12, 1995.

Invited symposium presentation, Miniature Synaptic Current Analysis of Ethanol Actions at Central Synapses, 1995 Research Society on Alcoholism Meeting, Steamboat Springs, CO, June 18, 1995.

Invited workshop presentation, Ethanol and Ifenprodil Insensitivity of NMDA Receptor-Dependent Long-Term Depression in Rat Hippocampus, Research Society on Alcoholism Meeting, Steamboat Springs, CO, June 19, 1995.

Synaptic Mechanisms of Ethanol Withdrawal: Delirium Tremens in a Dish, Wadsworth Neuroscience Research Center, Albany, NY, January 26, 1996.

Synaptic Mechanisms Underlying Ethanol Withdrawal Hyperexcitability in Hippocampal Slices and Explant Cultures, Department of Pharmacology and Toxicology, Texas A&M University, College Station, TX, February 20, 1996.

Organotypic Brain Slice Cultures For Functional Analysis of Alcohol-related Disorders: Novel Versus Conventional Preparations, Invited satellite workshop presentation, Society for Neuroscience Meeting, Washington, DC, April 10, 1996.

Pathophysiology and Toxicology Underlying Alcohol and HIV-Related CNS Disorders, University of Texas College of Pharmacy, Austin, TX, February 12, 1997.

Of Mice and Minis: Novel Forms and Analyses of Ethanol Effects on Synaptic Transmission, invited symposium presentation, Society for Neuroscience Meeting, New Orleans, LA, October 1997.

Miniature Synaptic Current Analysis of Ethanol Effects on Glutamatergic Synaptic Transmission, Research Society on Alcoholism Meeting, San Francisco, CA, July 21, 1997.

INVITED LECTURES, SYMPOSIA AND PRESENTATIONS: (cont.)

Synaptic Mechanisms in Alcohol-Related Brain Disorders, University of North Texas College of Osteopathic Medicine, Department of Pharmacology, Fort Worth, TX, May 12, 1998.

Novel Mechanisms of Ethanol Effects on Synaptic Transmission, invited symposium presentation, Winter Conference on Brain Research, Snowmass, CO, January 29, 1999.

Two Mechanisms of Ethanol Modulation of Synaptic Plasticity, Texas Research Society on Alcoholism Meeting, Austin, TX, March 2000.

DARPP-32 and the Regulation of Ethanol Sensitivity of NMDA Receptors, symposium co-chair, Research Society on Alcoholism Meeting, San Francisco, CA, July 2, 2002.

Learning To Drink: Ethanol and Synaptic Transmission in the Nucleus Accumbens, Invited Plenary Presentation, Spring Brain Conference, Sedona, AZ, March 2003.

Molecular and Imaging Techniques for Monitoring the Trafficking of Synaptic Proteins in Native Neuronal Preparations, Symposium chair and organizer, Research Society on Alcoholism Meeting, Fort Lauderdale, FL, June 2003.

Dependence and Withdrawal: The Yin and Yang of Synaptic Alterations in Alcohol Addiction, Texas A&M University, Department of Pharmacology, College of Medicine, College Station, TX, December 2, 2003.

Molecular and Imaging Techniques for Monitoring the Trafficking of Synaptic Proteins in Native Neuronal Preparations, Symposium chair and organizer, Winter Conference on Brain Research, Copper Mountain, CO, January 2004.

Learning to Drink: Synaptic Mechanisms in Dependence and Withdrawal, Gallo Center, San Francisco, CA, February 10, 2005.

Dopamine, DARPP and DTs: Synaptic Changes in Ethanol Dependence and Withdrawal, Skipper Bowles Alcohol Center, University of North Carolina School of Medicine, Chapel Hill, NC, February 21, 2005.

Tickling The Tipsy Terminal: Acute And Chronic Exposure and Action Potential Dependent Effects on Release, Invited symposium participant, Research Society on Alcoholism Meeting, Santa Barbara, CA, June 26, 2005.

The Killer D's: Dopamine, DARPP-32 and Drug Dependence, Department of Neuroscience, Baylor College of Medicine, Houston, TX, December 2, 2005.

REFEREED PUBLICATIONS:

1. Jope, R.S., Morrisett, R.A., Snead, O.C. Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. Experimental Neurology. 91:471-480, 1986.

2. Jope, R.S., Morrisett, R.A., Snead, O.C. Neurochemical consequences of status epilepticus induced in rats by administration of lithium and pilocarpine. Experimental Neurology 93:404-414, 1986.

3. Morrisett, R.A., Jope, R.S., Snead, O.C. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental Neurology 97:193-200, 1987.

4. Morrisett, R.A., Jope, R.S., Snead, O.C. Status epilepticus is produced by administration of cholinergic agonists to lithium-pretreated rats: Comparison to kainic acid. Experimental Neurology 98:594-605, 1987.

5. Morrisett, R.A., Chow, C., Nadler, J.V., McNamara, J.O. Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats. Brain Research 496:25-28, 1989.

6. Morrisett, R.A., Martin, D., Savage, D., Wilson, W.A., Swartzwelder, H.S. Prenatal ethanol exposure decreases sensitivity of adult rat hippocampus to N-methyl-D-aspartate. Alcohol 6:415-420, 1989.

7. Morrisett, R.A., Chow, C., Sakaguchi, T., Shin, C., McNamara, J.O. Inhibition of carbachol-stimulated phosphoinositide hydrolysis is dependent upon depolarization via channel activation. J Neurochemistry 54:1517-1525, 1990.

8. Morrisett, R.A., Rezvani, A.H., Overstreet, D., Janowsky, D.S., Wilson, W.A., Swartzwelder, H.S. MK-801 potently inhibits alcohol withdrawal seizures in rats. European J Pharmacology 176:103-105, 1990.

9. Morrisett, R.A., Mott, D.D., Lewis, D.V. Wilson. W.A., Swartzwelder, H.S. Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Developmental Brain Research 56:257-262, 1990.

10. Morrisett, R.A., Mott, D.O., Lewis, D.V., Swartzwelder, H.S., Wilson, W.A. GABAB-mediated inhibition of the NMDA component of synaptic transmission in area CA1 of rat hippocampus. J Neuroscience 11:203-209, 1991.

11. Martin, D., Morrisett, R.A., Bian, X-P., Wilson, W.A., Swartzwelder, H.S. Ethanol inhibition of NMDA-mediated depolarizations is increased in the presence of Mg++. Brain Research 546:227-234, 1991.

REFEREED PUBLICATIONS: (cont.)

12. Morrisett, R.A., Martin, D., Oetting, T.A., Wilson, W.A., Swartzwelder, H.S. Ethanol and Mg++ inhibit N-methyl-D-aspartate mediated synaptic potentials in an interactive manner. Neuropharmacology 30:1173-1178, 1991.

13. Hosford, D., Clark, S., Cao Z., Wilson, W.A., Lin, F-H., Morrisett, R.A., Huin, A. Activation of GABAB receptors in lethargic mice with absence seizures. Science 257:398-401, 1992.

14. Brucato, F., Morrisett, R.A., Wilson, W.A., Swartzwelder, H.S. The GABAB receptor antagonist, CGP-35348, inhibits paired pulse disinhibition in the rat dentate gyrus. Brain Research 588:150-153, 1992.

15. Xie, C.W., Morrisett, R.A., Lewis, D.V. Mu opiod receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus. J Neurophysiology 68:1113-1120, 1992.

16. Morrisett, R.A., Lewis, D.V., Swartzwelder, H.S., Wilson, W.A. Antiepileptic effects of GABAB receptor activation in Area CA3 of rat hippocampus. Brain Research 600:235-242, 1993.

17. Cohen, S.M., Martin, D., Morrisett, R.A., Wilson, W.A., Swartzwelder, H.S. Proconvulsant and anticonvulsant properties of ethanol: Studies of electrographic seizures in vitro. Brain Research 601:80-87, 1993.

18. Morrisett, R.A., Swartzwelder, H.S. Attenuation of hippocampal long-term potentiation by ethanol: A patch clamp analysis of glutamatergic and GABAergic mechanisms. J Neuroscience 13:2264-2272, 1993.

19. Zhang, G. and Morrisett, R.A. Ethanol inhibits tetraethylammonium-induced synaptic plasticity in area CA1 of rat hippocampus. Neuroscience Lett. 156:27-30, 1993.

20. Morrisett, R.A. Potentiation of NMDA receptor-dependent afterdischarges in rat dentate gyrus following in vitro ethanol exposure. Neuroscience Lett. 167:175-178, 1994.

21. Buller, A.L., Clark, H.C., Schneider, B.J., Morrisett, R.A., Monaghan, D.T. Anatomical and pharmacological properties of NMDA receptor subtypes: Native pharmacology predicted by subunit composition. J Neuroscience 14:5471-5484, 1994.

22. Morrisett, R.A., Zhang, G., Buller, A.L., Toews, M.L. Activation of the endogenous chloride current in Xenopus laevis oocytes by lysophosphatidic acid and blood serum. Pharmacology Communications 5:277-289, 1995.

REFEREED PUBLICATIONS: (cont.)

23. Liu, L., Brown III, J.C., Webster, W.W., Morrisett, R.A., Monaghan, D.T. Insulin potentiates NMDA receptor activity in Xenopus oocytes and rat hippocampus. Neuroscience Lett. 192:1-4, 1995.

24. Buller, A.L., Morrisett, R.A. and Monaghan, D.T. Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Molecular Pharmacology 48:717-723, 1995.

25. Zheng, J., Morrisett, R.A., Jianhua, Z. and Hexum, T.D. Neuropeptide Y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel. J Pharmacology Experimental Therapeutics 274:891-897, 1995.

26. Thomas, M.P., Webster, W.W., Norgren, R.B., Monaghan, D.T., Morrisett, R.A. Survival and functional demonstration of interregional pathways in fore/midbrain slice explant cultures, Neuroscience 85:615-626, 1998.

27. Thomas, M.P., Davis, M.I., Monaghan, D.T., Morrisett, R.A. Organotypic brain slice cultures for functional analysis of alcohol-related disorders: Novel versus conventional preparations. Alcoholism: Clinical Experimental Research 22:51-59, 1998.

28. Thomas, M.P., Monaghan, D.T., Morrisett, R.A. Evidence for a causative role of NMDA receptors in an in vitro model of alcohol withdrawal hyperexcitability. J Pharmacology Experimental Therapeutics 287:87-97, 1998.

29. Davis, M.I., Szarowski, D., Turner, J.N., Morrisett, R.A. and Shain, W. In vivo activation and in situ BDNF-stimulated nuclear translocation of mitogen-activated/extracellular signal-regulated protein kinase is inhibited by ethanol in the developing rat hippocampus. Neuroscience Lett. 272:95-98, 1999.

30. Lewohl, J.M., Wilson, W.R., Mayfield, R.D., Brozowski, S.J., Morrisett, R.A. and Harris, R.A. G-protein-coupled inwardly rectifying potassium channels: Targets of ethanol action. Nature Neuroscience 2:1084-1090, 1999.

31. Thomas, M.P. and Morrisett, R.A. Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal. Neuropharmacology 39:218-226, 2000.

32. Hendricson, A.W., Miao, C.L.A., Lippmann, M.J., Morrisett, R.A. Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression. J Pharmacology Experimental Therapeutics 301:938-944, 2002.

REFEREED PUBLICATIONS: (cont.)

33. Maldve, R.E., Zhang, T.A., Ferrani-Kile, K., Schreiber, S.S., Lippmann, M.J., Snyder, G.L., Fienberg, A.A., Leslie, S.W., Gonzales, R.A., Morrisett, R.A. DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. Nature Neuroscience 5:641-648, 2002.

34. Hendricson, A.W., Thomas, M.P., Lippmann, M.P., Morrisett, R.A. Suppression of L-type voltage-gated calcium channel dependent synaptic plasticity by ethanol: Analysis of miniature synaptic currents and dendritic calcium transients. J Pharmacology Experimental Therapeutics 307:550-558, 2003.

35. Maldve, R.E., Chen, X., Zhang, T.A., Morrisett, R.A. Ethanol selectively inhibits enhanced vesicular release at excitatory synapses: Real-time visualization in intact hippocampal slices. Alcoholism: Clinical Experimental Research 28:143-152, 2004.

36. Hendricson, A.H., Sibbald J.R., Morrisett, R.A. Ethanol alters the frequency, amplitude, and decay kinetics of Sr2+-supported, asynchronous NMDAR mEPSCs in rat hippocampal slices. J Neurophysiology 91:2568-2577, 2004.

37. Diaz, L.M., Maiya, R., Sullivan, M.A., Han, Y., Walton H.A., Boehm S.L. II, Bergeson S.E., Mayfield R.D., Morrisett R.A. Sindbis viral-mediated expression of eGFP-dopamine D1 receptors in situ with real-time two-photon microscopic detection. J Neuroscience Methods 139:25-31, 2004.

38. Zhang, T.A., Wilkemeyer, M.F., Lippmann, M.J., Charness, M.E., Morrisett, R.A. Synergistic effects of peptide fragment NAPVSIPQ on ethanol inhibition of synaptic plasticity in rat hippocampus, Neuroscience 134:583-93, 2005.

39. Zhang T.A., Hendricson, A.W., Morrisett, R.A. Dual synaptic sites of D1-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens. Synapse 58:30-44, 2005.

40. Hendricson, A.W., Maldve, R.E., Zhang, T.A., Diaz, L.M., Han, Y., Morrisett, R.A. Aberrant synaptic activation of NMDA receptors underlies ethanol withdrawal hyperexcitability, J Neuroscience, under revision.

PUBLICATIONS PENDING:

Diaz, L.M., Han, Y., Maiya R., Shear, J.B., Bergeson, S.E., Mayfield, R.D., Morrisett, R.A. Ethanol and dopamine induce PKA-dependent D1-dopamine receptor re-distribution in nucleus accumbens of parasagittal brain slice cultures: Real-time two-photon detection, in preparation.

Schreiber, S.S., Reyna, G., Morrisett, R.A., Maldve, R.E. Regional and temporal heterogeneity in ethanol modulation of DARPP-32 phosphoisoforms in the nucleus accumbens and amygdala, in preparation.

REVIEW ARTICLES, BOOK CHAPTERS, MEETING PROCEEDINGS:

1. Nadler, J.V., Martin, D., Bowe, M.A., Morrisett, R.A., McNamara, J.O. Kindling, Prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA. Adv. Exp. Med. Biol.286: 407-417, 1990, Review article.

2. McNamara, J.O., Morrisett, R.A., Nadler, J.V. Recent advances in understanding mechanisms of the kindling model. In: Advances in Neurology, P. Chauvel (ed.) 57:555-560, 1992, Book chapter.

3. Morrisett R.A. Electrophysiologic characteristics of heteromeric recombinant NMDA receptors: Comparison with native receptors. In: The Ionotropic Glutamate Receptors, R. Wenthold, D. Monaghan (eds.), Humana Press, NY, 1996, Book chapter.

4. Gendelman, H.E., Persidsky, Y., Ghorpade, A., Limonges, J., Stins, M., Fiala, M., Morrisett, R.A. The neuropathogenesis of HIV-1 dementia. AIDS. 1997; 11 Suppl A: S35-S45, 1997, Review article.

5. Morrisett, R.A. and Thomas, M.P. Of mice and minis: Novel forms and analyses of ethanol effects on synaptic transmission. In: The Drunken Synapse, Y. Liu and W.A. Hunt, (eds.), Plenum Press, 1999, Book chapter.

6. Harris, R.A., Morrisett, R.A. Two-shot cocktail: Adenosine, dopamine and a twist of bg. Nature Medicine 8:777-779, 2002, Commentary.

7. Chandler, L.J., Bonci, A., Wand, G.S., Morrisett, R.A. Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterations. Symposium Proceedings, Research Society on Alcoholism 2003 Annual Meeting. Alcoholism: Clinical Experimental Research, 28:1129-1136, 2004.

8. Chandler, L.J., Carpenter-Hyland, E., Hendricson, A.W., Maldve, R.E., Morrisett, R.A, Zhou, F.C., Sari, Y., Bell, R., Szumlinski, K.K. Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure. Symposium proceedings, Research Society on Alcoholism 2005 annual meeting. Alcohol Clinical Experimental Research, 30:368-76, 2006.

9. Roberto, M., Treistman, S.N., Pietrzykowski, A.Z., Weiner, J., Galindo, R., Mameli, M., Valenzuela, F., Zhu, P.J., Lovinger, D., Zhang, T.A., Hendricson A.H., Morrisett, R., Siggins, G.R. Actions of Acute and Chronic Ethanol on Presynaptic Terminals. Symposium proceedings, Research Society on Alcoholism 2005 annual meeting. Alcohol Clinical Experimental Research, 30:222-32, 2006.

10. Zhang T.A., Maldve R.E., Morrisett R.A. Coincident signaling in mesolimbic structures underlying alcohol reinforcement, Biochem Pharmacol, invited commentary, in press.

ABSTRACTS:

1. Snead, O.C., Morrisett, R.A., Jope, R.S. A new animal model of status epilepticus. Amer. Acad. Neurol. Abstr. Neurol. 35:(suppl.1) 134 (1984).

2. Morrisett, R.A., Jope, R.S., Snead, O.C. Characterization of a model of status epilepticus in rats. Soc. Neurosci. Abstr. 11:1241 (1985).

3. Morrisett, R.A., Jope, R.S., Snead, O.C. Cholinergic metabolism and pharmacologic characterization of status epilepticus induced by lithium and pilocarpine. Soc. Neurosci. Abstr. 12:898 (1986).

4. Morrisett, R.A., Nadler, J.V., McNamara, J.O. Evidence for enhanced NMDA-receptor inhibition of carbachol-stimulated PI hydrolysis from kindled rats. Soc. Neurosci. Abstr. 13:946 (1987).

5. Chow, C., Morrisett, R.A., McNamara, J.O. Comparison of the mechanism of NMDA and phorbol-ester inhibition of carbachol-stimulated PI hydrolysis in rat hippocampal slices. Soc. Neurosci. Abstr. 14:130 (1988).

6. Morrisett, R.A., Martin, D., Savage, D., Wilson, W.A., Swartzwelder, H.S. Prenatal ethanol exposure decreases sensitivity of adult rat hippocampus to N-methyl-D-aspartate. J. Alcohol Alcoholism 6:415-420 (1989).

7. Morrisett, R.A., Martin, D., Savage, D., Wilson, W.A., Swartzwelder, H.S. Prenatal ethanol exposure decreases sensitivity of adult rat hippocampus to N-methyl-D-aspartate. Alcohol.: Clin. Exp. Res. 13:126N (1990).

8. Martin, D., Morrisett, R.A., Savage, D., Wilson, W.A., Swartzwelder, H.S. Prenatal ethanol exposure enhances Mg++ regulation of depolarizing responses to NMDA in rat hippocampal CA1 pyramidal cells. Alcohol.: Clin. Exp. Res. 13:125N (1990).

9. Martin, D., Cohen, S., Morrisett, R.A., Wilson, W.A., Swartzwelder, H.S. Ethanol effects upon rat hippocampal epileptiform activity. Alcohol.: Clin. Exp. Res. 99:279p (1990).

10. Martin, D., Morrisett, R.A., Swartzwelder, H.S., Wilson, W.A. Acute effects of ethanol on rat hippocampal excitatory amino acid receptors. Alcohol Alcoholism 25:582 (1990).

11. Morrisett, R.A., Rezvani, A.H., Overstreet, D., Janowsky, D.S., Wilson, W.A., Swartzwelder, H.S. MK-801 potently inhibits alcohol withdrawal seizures in rats. Alcohol Alcoholism 25:582 (1990).

12. Morrisett, R.A., Mott, D.D., Swartzwelder, H.S., Lewis, D.V., Wilson, W.A. GABAB receptor-mediated inhibition of the NMDA component of synaptic transmission. Soc. Neurosci. Abstr. 16:375 (1990).

13. Wilson, W.A., Morrisett, R.A., Mott, D.D., Swartzwelder, H.S., Lewis, D.V. Evidence for Mg++ dependence of GABAB receptor-mediated inhibition of the NMDA component of synaptic transmission. Soc. Neurosi. Abstr. 16:463 (1990).

14. Morrisett, R.A., Mott, D.D., Lewis, D.V., Wilson, W.A., Swartzwelder, H.S. Ethanol reduced NMDA-mediated hyperexcitability induced by a priming paradigm in rat dentate gyrus. Alcohol.: Clin. Exp. Res. 15:324 (1991).

15. Martin, D., Cohen, S., Morrisett, R.A., Wilson, W.A., Swartzwelder, H.S. Ethanol effects upon rat hippocampal epileptiform activity. Alcohol.: Clin. Exp. Res. 15:324 (1991).

ABSTRACTS: (cont.)

16. Morrisett, R.A., Wilson, W.A., Swartzwelder, H.S. Evidence that ethanol reduces GABAB-mediated disinhibition and synaptic plasticity induced by a priming paradigm in rat dentate gyrus. Soc. Neurosci. Abstr. 17:1169 (1991).

17. Clark, S., Morrisett, R.A., Wilson, W.A., Hosford, D.A. Evidence for enhanced GABAB-mediated inhibition in hippocampal slices from lethargic mice, a genetic model of absence epilepsy. Soc. Neurosci. Abstr. 17:170 (1991).

18. Xie, C.W., Morrisett, R.A., Lewis, D.V. Mu opiod receptor-mediated disinhibition in rat dentate gyrus. Soc. Neurosci. Abstr. 17:244 (1991).

19. Mott, D.D., Xie, C.W., Morrisett, R.A., Swartzwelder, H.S., Wilson, W.A., Lewis, D.V. GABAB receptor-mediated paired pulse disinhibition reveals an NMDA-component of the EPSP. Soc. Neurosci. Abstr. 17:1169 (1991).

20. Cohen, S., Martin, D., Morrisett, R.A., Wilson, W.A., Swartzwelder, H.S. In vitro effects of ethanol on hippocampal electrographic seizures. Soc. Neurosci. Abstr. 17:1601 (1991).

21. Morrisett, R.A., Swartzwelder, H.S., Wilson, W.A., Lopez, S.R., Paxton, L.L., Savage, D.D. Effect of prenatal ethanol exposure on hippocampal NMDA receptors and magnesium regulation of NMDA receptor function in rat offspring. Alcohol.: Clin. Exp. Res. 16:356 (1992).

22. Morrisett, R.A., A slice patch analysis of ethanol effects on amino acid-induced synaptic currents. Soc. Neurosci. Abstr. 18:1231 (1992).

23. Buller, A.L., Morrisett, R.A., Seeburg, P.H., Monaghan, D.T. Interaction of ethanol (EtOH) with recombinant heteromeric NMDA receptors expressed in Xenopus oocytes. Alcohol.: Clin. Exp. Res. 17:475 (1993).

24. Morrisett, R.A. Selective effects of in vitro ethanol exposure and withdrawal on NMDA receptor-mediated epileptiform discharges in dentate gyrus. Alcohol.: Clin. Exp. Res. 17:474 (1993).

25. Morrisett, R.A. Ethanol effects on GABAa synaptic currents in hippocampus following elevation of intracellular cyclic-AMP. Alcohol.: Clin. Exp. Res. 17:472 (1993).

26. Buller, A.L., Morrisett R.A., Monaghan, D.T. The NR2 subunit contributes to the pharmacological diversity of native NMDA receptors. Soc. Neurosci. Abstr. 19:1356 (1993).

27. Morrisett, R.A. and Zhang, G. NMDA receptors mediate enhancement of epileptiform discharges in dentate gyrus following in vitro ethanol withdrawal. Soc. Neurosci. Abstr. 19:1870 (1993).

28. Morrisett, R.A. Ethanol does not inhibit NMDA receptor-dependent long-term depression of synaptic transmission in area CA1 of hippocampal slices from immature rats. Alcohol.: Clin. Exp. Res. 18:444 (1994).

29. Dittmer, K., Elmquist, E., Zhang, G., Morrisett, R.A. Further characterization of in vitro ethanol withdrawal effects on dentate afterdischarges. Alcohol.: Clin. Exp. Res. 18:445 (1994).

30. Zheng, J., Morrisett, R.A., Zhu, J., Hexum, T.D., Neuropeptide Y blocks the nicotinic receptor-ligand gated ion channel in bovine chromaffin cells via a pertussis toxin-insensitive process. Soc. Neurosci. Abstr. 20:917 (1994).

ABSTRACTS: (cont.)

31. Thomas, M.P., Larson H.C., Monaghan D.T., Morrisett, R.A. The hippocampal explant slice culture as a model system for analysis of ethanol effects on NMDA synaptic currents. Alcohol.: Clin. Exp. Res. 19:(1995).

32. Thomas, M.P., Monaghan, D.T., Norgren, R.B. Morrisett, R.A. Intact corticostriatal synapses in organotypic cultures of whole horizontal sections of rat brain. Soc. Neurosci. Abstr. 21:347 (1995).

33. Liu, L., Brown III, J.C., Webster, W.W., Morrisett, R.A., Monaghan, D.T. Insulin potentiates NMDA receptor activity in Xenopus oocytes and rat hippocampus. Soc. Neurosci. Abstr. 21:835 (1995).

34. Thomas, M.P. and Morrisett, R.A. Withdrawal from chronic ethanol exposure in hippocampal explant slice cultures: Epileptiform events correlate with enhancement of the NMDAR component of synaptic transmission. Soc. Neurosci. Abstr. 22:468 (1996).

35. Ferrani-Kile, K., Leslie, S.W., Morrisett, R.A. Dopamine receptor modulation of NMDA responses in hippocampus and striatum: Occlusion of ethanol inhibition. Res. Soc. Alcohol. Abstr. 25:311 (1999).

36. Wilson, W.R., Levin, P.S., Leslie, S.W., Morrisett, R.A. Growth factor modulation of NMDA responses in primary cultures of cerebellar granule neurons. Res. Soc. Alcohol. Abstr. 25:747 (1999).

37. Galindo, D.G., Edwards, S., Simmons, D.L., Doherty, J.M., Scott, A.M., Hughes, P.D., Morrisett, R.A., Wilcox, R.E. Comparative effects of a full D1 agonist, a D2 receptor agonist, and ethanol on the phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor. Soc. Neurosci. Abstr. 290.6 (2000).

38. Maldve, R.E., Ferrani-Kile, K., Snyder, G., Leslie, S.W., Morrisett, R.A. Modulation of ethanol sensitivity of nmda receptor mediated responses in neostriatum by darpp-32 phosphosphorylation. Soc. Neurosci. Abstr. 290.7 (2000).

39. Popp, R.L., Hughes, P.D., Leslie, S.W., Morrisett, R.A. Identification of and subcellular localization of PKC isoforms contained in CGC. Soc. Neurosci. Abstr. 290.8 (2000).

40. Maldve, R.E., Miao, C.L., Lippmann, M.J., Snyder, G.L., Fienberg, A.A., Morrisett, R.A. Regulation of the ethanol sensitivity of NMDA receptors by D1 receptor activation in DARPP-32 knockout mice. Res. Soc. Alcohol. Abstr. 25:592 (2001).

41. Maldve, R.E., Miao, C.L., Lippmann, M.J., Snyder, G.L., Fienberg, A.A., Morrisett, R.A. Molecular mechanisms underlying alcohol reinforcement in mesocorticolimbic pathways. Soc. Neurosci. Abstr. 221.1 (2001).

42. Miao, C.L., Lippmann, M.J., Morrisett, R.A. Correlation between ethanol and ifenprodil effects on NMDA receptor dependent long term depression. Res. Soc. Alcohol. Abstr. 25:14 (2001).

43. Morrisett, R.A., Zhang, T.A., Wilkemeyer, M.F., Menari C., Charness, M.E. Effects of the ethanol antagonists, octanol and NAP, on ethanol inhibition of synaptic plasticity. Res. Soc. Alcohol. Abstr. 26:540 (2002).

ABSTRACTS: (cont.)

44. Maiya, R., Bergeson, S.E., Diaz, L.M., Harris, R.A., Levin, P.S., Morrisett, R.A., Scott H.A., Mayfield, R.D. Sindbis virus-mediated delivery of GFP labeled dopamine transporter into neuronal cells. Soc. Neurosci. Abstr. 745.1 (2002).

45. Maldve, R.E., Schreiber, S.S., Steinwand, T.V., Morrisett, R.A. Immunofluorescent localization of DARPP-32 and DARPP-32 phosphorylation in the extended amygdala. Soc. Neurosci. Abstr. 832.1 (2002).

46. Chen, X.C. and Morrisett, R.A. DIrect visualization of ethanol modulation of synaptic vesicle function in intact hippocampal slices. Soc. Neurosci. Abstr. 342.1 (2002).

47. Hendricson, A.W., Miao, C.L., Lippman, M.J., Morrisett, R.A. Ethanol and ifenprodil potentiate NMDA receptor-dependent hippocampal LTD. Res. Soc. Alcohol. Abstr. 26:623 (2002).

48. Hendricson, A.W. and Morrisett, R.A. Quantal analysis of ethanol inhibition of Sr++ -supported NMDA mEPSCs in hippocampus. Res. Soc. Alcohol. Abstr. 27:13 (2003).

49. Zhang, T.A., Hendricson, A.W., Morrisett, R.A. Quantal analysis of ethanol inhibition of Sr++ -supported NMDA mEPSCs in the nucleus accumbens. Res. Soc. Alcohol. Abstr. 27:13 (2003).

50. Herring, B.E., Mayfield, R.D., Berlanga, M.L., Camp, M.C., Morrisett, R.A. Alcantara AA. Cholinergic interneurons in the shell compartment of the nucleus accumbens are activated by ethanol. Res. Soc. Alcohol. Abstr. 27:14 (2003).

51. Schreiber, S.S., Reyna, G., Morrisett, R.A., Maldve, R.E. A biphasic response to ethanol of DARPP-32 phospho-isoforms in the nucleus accumbens. Res. Soc. Alcohol. Abstr. 27:52 (2003).

52. Maiya, R., Diaz, L.M., Alcantara, A.A., Bergeson, S.E., Boehm, S.L., Croyle, M., Levin, P.S., Scott, H., Morrisett, R.A., Mayfield, R.D. In vivo viral delivery of GFP-labeled dopamine transporter in mouse brain. Res. Soc. Alcohol. Abstr. 27:89 (2003).

53. Diaz, L.M., Maiya, R., Boehm, S.L., Scott, H.A., Bergeson, S.E., Mayfield, R.D., Morrisett, R.A. Sindbis viral delivery of eGFP labeled dopamine D1 receptors into primary cultured neurons, brain slice culture and in vivo. Res. Soc. Alcohol. Abstr. 27:93 (2003).

54. Hendricson, A.W. and Morrisett, R.A. Analysis of Sr++-dependent asynchronous NMDA mEPSCs: Pre- and post-synaptic sites of ethanol action. Soc. Neurosci. Abstr. 108.7 (2003).

55. Zhang, T.A., Hendricson, A.W., Morrisett, R.A. Analysis of ethanol inhibition of Sr++-supported NMDA mEPSCs in the nucleus accumbens. Soc. Neurosci. Abstr. 108.7 (2003).

56. Diaz, L.M., Maiya, R., Boehm, S.L., Scott, H.A., Bergeson, S.E., Mayfield, D.M., Morrisett, R.A. Sindbis viral delivery of eGFP-dopamine D1 receptors into native neuronal preparations. Soc. Neurosci. Abstr. 160.14 (2003).

57. Maldve, R.E., Guerrero, P.A., Morrisett, R.A. Detection of ethanol and fluoxetine-dependent DARPP-32 phosphoisoforms in the rat amygdala. Soc. Neurosci. Abstr. 163.15 (2003).

58. Schreiber, S.S., Reyna, G., Morrisett, R.A., Maldve R.E. Visualizing alterations in DARPP-32 phosphorylation using immunoblot analysis and confocal microscopy. Alcohol.: Clin. Exp. Res. 28:53A Suppl. (2004).

59. Hendricson, A.W. and Morrisett, R.A. Determining the role of NMDA receptors in ethanol withdrawal seizures: Patch-clamp analysis in hippocampal organotypic cultures Alcohol.: Clin. Exp. Res. 28:57A Suppl. (2004).

60. Diaz, L.M., Han, Y., Morrisett, R.A. Real-time two-photon imaging of ethanol facilitation of agonist-induced clustering of dopamine D1 receptors in viable medium spiny accumbal neurons. Alcohol.: Clin. Exp. Res. 28:131A Suppl. (2004).

61. Zhang, T.A., Hendricson, A.W., Morrisett, R.A. Multiple sites of ethanol modulation of NMDA receptor-mediated synaptic transmission in the nucleus accumbens. Alcohol.: Clin. Exp. Res. 28:132A Suppl. (2004).

62. Hendricson, A.W., Han, Y., Guerrero, P., Maldve, R.E., Morrisett, R.A. NMDA receptors and molecular mechanisms underlying alcohol withdrawal seizures, Soc. Neurosci. Abstr. 117.1 (2004).

63. Zhang, T.A., Hendricson, A.W., Morrisett, R.A. D1-dopamine receptor activation reverses the presynaptic and postsynaptic effects of ethanol on asynchronous NMDA mEPSCs in the nucleus accumbens, Soc. Neurosci. Abstr. 234.2 (2004).

64. Dhaher, R., Phillips, T.J., Morrisett, R.A., Mayfield, D.R., Hitzemann, R. Viral vector manipulations made to the lateral posterior portion of the bed nucleus of the stria terminalis (BSTLP) decreases ethanol consumption in C57BL/6J (B6) mice, Soc. Neurosci. Abstr. 234.22 (2004).

65. Sullivan, M.A., Diaz, L.M., Han, Y., Morrisett, R.A. Electrophysiological analysis of medium spiny neurons following viral mediated gene transfer of eGFP-D1-dopamine receptors, Soc. Neurosci. Abstr. 395.6 (2004).

66. Wilde, J.D., Han, Y., Morrisett, R.A., Maldve, R.E. RT-PCR analysis of cocaine and amphetamine related transcript (CART) following in vivo ethanol administration, Soc. Neurosci. Abstr. 914.6 (2004).

67. Zhang, T.A., Rakhilin, S.V., Fienberg, A.A., Nairn, A.C., Greengard, P., Morrisett, R.A. Analysis of D1 modulation of ethanol sensitivity of NMDA EPSCs in the nucleus accumbens of RCS knock-out mice. Alcohol.: Clin. Exp. Res. 29:534 (2005).

68. Diaz, L.M., Maiya, R., Han, Y., Bergeson, S.E., Mayfield, R.D., Morrisett, R.A. Real-time two-photon imaging of dopamine and ethanol induced clustering of dopamine D1 receptors in viable parasagittal explants. Alcohol.: Clin. Exp. Res. 29:279 (2005).

CONSULTANTSHIPS:

1. JMH Educational Marketing, NIH SBIR consultant for development of a high school curriculum on alcohol and alcoholism, one of 4 national content experts, 2002-present. Invited to continue for phase II, spring 2005.

2. Rice University, Center for Technology in Teaching and Learning, NIAAA Middle School Alcohol education project, awarded spring 2005.

3. McGrath, Moore and Partners, LTD, A. Crowe and family vs Albertson's grocery, Omaha, NE, deposition given, 34 hrs, 1997-1998.

4. JC Bailey, PC, Benton vs Aquirre, Longview, TX, 23.5 hrs,1999.

5. Henderson vs. ,4 hrs, February 2000.

6. Hibler v United Regional Health Care, 22.5 hrs, 2001-2002.

7. Six vs ., 13 hrs, 2002.

8. Merriman, Patterson and Allison, Longview, TX, Thompson and Dillard vs. Dagley et al., 21 hrs, October 1998.

9. Smith Moore LLP, Greensboro, NC, Whicker et al., vs Kent, 28 hrs, 2002.

10. McGinnis, Lockridge and Kilgore LLP, Austin, TX, Pekar vs White, 2001.