Student Information Training Programs Research Centers

Pharmacology & Toxicology

Research and Graduate Training Faculty

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Morrisett, Richard, Ph.D.
Professor of Pharm./Tox.
Revco Foundation Fellow
PHR 5.218C
512-471-1911
ramorris@austin.utexas.edu


Representative Publications

Hendricson, A.W., Maldve, R.E., Zhang, T.A., Diaz, L.M., Han, Y., Morrisett, R.A. Aberrant synaptic activation of NMDA receptors underlies ethanol withdrawal hyperexcitability, J Pharmacol Exp Therap, under revision.

Zhang, T.A., Wilkemeyer, M.F., Lippmann, M.J., Charness, M.E., Morrisett, R.A. Synergistic effects of peptide fragment NAPVSIPQ on ethanol inhibition of synaptic plasticity in rat hippocampus,Neuroscience 134:583-93, 2005.

Zhang T.A., Hendricson, A.W., Morrisett, R.A. Dual synaptic sites of D1-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens. Synapse 58:30-44, 2005.

Maldve, R.E., Chen, X., Zhang, T.A., Morrisett, R.A. Ethanol selectively inhibits enhanced vesicular release at excitatory synapses: Real-time visualization in intact hippocampal slices. Alcoholism: Clinical Experimental Research 28:143-152, 2004.

Hendricson, A.H., Sibbald J.R., Morrisett, R.A. Ethanol alters the frequency, amplitude, and decay kinetics of Sr2+-supported, asynchronous NMDAR mEPSCs in rat hippocampal slices. J Neurophysiology 91:2568-2577, 2004.

Diaz, L.M., Maiya, R., Sullivan, M.A., Han, Y., Walton H.A., Boehm S.L. II, Bergeson S.E., Mayfield R.D., Morrisett R.A. Sindbis viral-mediated expression of eGFP-dopamine D1 receptorsin situ with real-time two-photon microscopic detection. J Neuroscience Methods 139:25-31, 2004.

Hendricson, A.W., Thomas, M.P., Lippmann, M.P., Morrisett, R.A. Suppression of L-type voltage-gated calcium channel dependent synaptic plasticity by ethanol: Analysis of miniature synaptic currents and dendritic calcium transients.J Pharmacology Experimental Therapeutics 307:550-558, 2003.

Maldve RE, Zhang TA, Ferrani-Kile K, Schreiber SS, Lippmann MJ, Snyder GL, Fienberg AA, Leslie SW, Gonzales RA, Morrisett RA. DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens, Nature Neuroscience, 5: 641-648, 2002. (pdf)

Harris RA, Morrisett RA. Two-shot cocktail: Adenosine, dopamine and a twist of β γ. Nature Medicine, 8:777-779, 2002. (pdf)

Hendricson AW, Miao CLA, Lippmann MJ, Morrisett R.A. Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression. J. Pharmacol. Exp. Ther., 301: 938-944, 2002. (pdf)

Thomas M.P. and Morrisett R.A. Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal, Neuropharmacology, 39:218-226,2000. (pdf)

Lewohl J.M., Wilson W.R., Mayfield, R.D., Brozowski, S.J., Morrisett, R.A. and Harris, R.A. G-protein-coupled inwardly rectifying potassium channels: Targets of ethanol action. Nature Neuroscience, 2:1084-90, 1999.(pdf)

Morrisett, R.A. and Thomas, M.P. Of Mice and Minis: Novel forms and analyses of ethanol effects on synaptic transmission. In: The Drunken Synapse, Y. Liu and W.A. Hunt., eds., Plenum Press, 1999.

Thomas, M.P., Webster, W.W., Norgren R.B, Monaghan D.T., Morrisett, R.A. Survival and functional demonstration of interregional pathways in fore/midbrain slice explant cultures, Neuroscience 85: 615-626 , 1998.

Thomas, M.P., Davis, M.I., Monaghan, D.T., Morrisett, R.A. Organotypic brain slice cultures for functional analysis of alcohol-related disorders: Novel versus conventional preparations. Alcoholism: Clinical Exp. Res. 22: 51-59, 1998.

Thomas, M.P., Monaghan D.T., Morrisett, R.A. Evidence for a causative role of NMDA receptors in an in vitro model of alcohol withdrawal hyperexcitability. J. Pharmacol. Exp. Therap. 287: 87-97, 1998. (pdf)

Morrisett R.A. Electrophysiologic characteristics of Heteromeric Recombinant NMDA receptors.: Comparison with native receptors. In: The Ionotropic Glutamate Receptors, R. Wenthold, D. Monaghan (eds.), Humana Press, NY, 1996.

Zheng J., Morrisett R.A., Jianhua Zhu and Hexum, T.D. Neuropeptide Y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel. J. Pharmacol. Exp. Therap. 274: 891-897, 1995.

Buller A.L., Morrisett, R.A. and Monaghan, D.T. Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol. Pharmacol. 48: 717-723, 1995.

Buller, A.L., Clark, H.C., Schneider, B.J., Morrisett, R.A., Monaghan, D.T. Anatomical and pharmacological properties of NMDA receptor subtypes: Native pharmacology predicted by subunit composition. J. Neuroscience 14: 5471-5484, 1994.

Morrisett, R.A., Swartzwelder, H.S. Attenuation of hippocampal long-term potentiation by ethanol: A patch clamp analysis of glutamatergic and GABAergic mechanisms. J. Neuroscience 13: 2264-2272, 1993.

Hosford, D., Clark, S., Cao Z., Wilson, W.A., Lin, F-H., Morrisett, R.A., Huin, A. Activation of GABAB receptors in lethargic mice with absence seizures. Science 257: 398-401, 1992.

Xie, C.W., Morrisett, R.A., Lewis, D.V. Mu opiod receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus. J. Neurophysiology 68: 1113-1120 (1992).

Morrisett, R.A., Mott, D.O., Lewis, D.V., Swartzwelder, H.S., Wilson, W.A. GABAB-mediated inhibition of the NMDA component of synaptic transmission in area CA1 of rat hippocampus. J. Neuroscience 11: 203-209 (1991).


More information about Dr. Morrisett
> CV
> Affiliations & Honors
> Return to Morrisett's Home Page


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Last Reviewed: May 20, 2008

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


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