Transport of proteins and lipids between membrane bound subcellular organelles is essential for life. Fundamental processes such as biosynthetic secretion, ion homeostasis, receptor-mediated endocytosis, intracellular signaling, and synaptic transmission depend on membrane trafficking. Alterations in trafficking can have devastating consequences, and several incurable human diseases such as cystic fibrosis, Alzheimer's disease, Huntington's disease and Wilson's disease occur due to defects or mutations in specific trafficking factors that subsequently alter specific subcellular processes. We are interested in understanding how membrane trafficking regulates physiologically relevant cellular processes and how defects in trafficking alter cell physiology to induce human disease. Current projects in the lab focus on: 1. Studying the role of trafficking in metal homeostasis and induced neurotoxicity; 2. Elucidating the mechanisms mediating intracellular transport of Shiga and other bacterial toxins. Please view our lab website to read more about our research, publications, and available positions.
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.