The longstanding focus of my research program is to decipher the molecular and cellular mechanisms by which exposure to certain environmental (e.g., phthalate acid ester-based plasticizers) or clinical chemotherapeutic agents (e.g., cisplatin) can result in disruption of male reproduction. Specifically, the unifying theme of the research conducted in my laboratory is targeted at understanding the paracrine cellular signaling mechanisms between the Sertoli cells and germ cells in the testis that regulate the death (and/or survival) of germ cells by the process of apoptosis.
Recent experimental findings in my laboratory have implicated the cells of the innate immune system in the exacerbation of phthalate-induced injury to the testis. Interestingly, the infiltration of these immune cells may account, in part, for the long recognized differences in the age- and species-dependent sensitivity to MEHP-induced testicular injury and germ cell loss. The inappropriate loss of testicular germ cells via apoptosis during various developmental periods of life could ultimately lead to clinical male infertility in adulthood. It is anticipated that the mechanistic insights garnered from our research will be useful for predicting and preventing human reproductive health risks to chemicals found in the environment.More about Richburg's Lab and Research
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.