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Pharmacology & Toxicology

Research and Graduate Training Faculty

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Richburg, John H., Ph.D.
Division Head, Professor of Pharm./Tox.
Gustavus & Louise Pfeiffer
Professorship in Toxicology
BME 3.510A
512-471-4736
john.richburg@austin.utexas.edu


Curriculum Vitae


NAME: John Henry Richburg, Ph.D., Associate Professor (Tenure)

ADDRESS:

The University of Texas at Austin
College of Pharmacy
Division of Pharmacology and Toxicology
1 University Station, A1915
Austin, Texas 78712-0125
Office: (512) 471-4736; Fax: (512) 471-5002
Email: John_Richburg@mail.utexas.edu

DEGREES EARNED:
B.S., Ph.D.

PRIMARY APPOINTMENTS:

1996 -1997 BROWN UNIVERSITY
Department of Pathology and Laboratory Medicine
•Assistant Professor (Research)
1997-2003 THE UNIVERSITY OF TEXAS AT AUSTIN
College of Pharmacy, Division of Pharmacology and Toxicology
•Assistant Professor
2003-present THE UNIVERSITY OF TEXAS AT AUSTIN
College of Pharmacy, Division of Pharmacology and Toxicology
•Associate Professor (with tenure)
•Head, Division of Pharmacology and Toxicology (9/04-present).
•William I. Dismukes Pharmacy Fellow (9/04-present).
•Director, NIEHS T32 Toxicology Training Program (9/03-present).
•Director, Center for Molecular and Cellular Toxicology (9/05-present)
•Toxicology Graduate Student Advisor, 1998-2005.
•Associate Director, NIEHS Center for Research on Environmental Disease (4/06-present)


ADJUNCT APPOINTMENTS:
2002-2003 THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER
Department of Carcinogenesis
•Assistant Professor (Adjunct)
9/03-present THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER
Department of Carcinogenesis
•Associate Professor (Adjunct)

EDUCATION:
1987 NORTHEASTERN UNIVERSITY, Boston, MA
College of Pharmacy and Allied Health Professions
Bachelor of Science in Toxicology, Cum Laude
Honors
: Dean's List; Toxicology Honors Program
1993 RUTGERS, THE STATE UNIVERSITY OF NJ / UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL
Joint Graduate Program in Toxicology, Piscataway, NJ
Doctor of Philosophy in Toxicology
Mentor: Frederick C. Kauffman, Ph.D.
•Thesis: "Inhibition of agonist-stimulated calcium influx in isolated rat hepatocytes by diisopropyl fluorophosphates."
1993 – 1995 BROWN UNIVERSITY
Department of Pathology and Laboratory Medicine
Postdoctoral Fellow, Environmental Pathology Training Grant (NIEHS T32)
Mentor: Kim Boekelheide, M.D., Ph.D.

AWARDS & HONORS:

1994 Postdoctoral Student Award, Reproductive and Developmental Toxicology Subsection, Society of Toxicology
1993-1995 Postdoctoral Fellow, Environmental Pathology Training Grant (T32 ES 07272).
11/1997 Scientist of the Month,” Center for Research on Environmental Disease and the UT/MD Anderson Cancer Research Center at Science Park.
11/1999 Nominated for the UT College of Pharmacy, Pharmacy Council, Texas Excellence in Teaching Award.
11/2004 Nominated for the UT College of Pharmacy, Pharmacy Council, Texas Excellence in Teaching Award.
09/01/2004-present William I. Dismukes Fellowship in Pharmacy


RESEARCH SUPPORT (current year direct costs):
A. Active Funding
•1R03 ES014386-01(Richburg) 1/16/2006 – 12/31/2008 25%
NIH/NIEHS $50,000
Cisplatin and Mechanisms of long-term male infertility

The major goals of this project are to elucidate the mechanism(s) of testicular injury that lead to a lasting failure of spermatogenesis and infertility after exposure to cisplatin.

•5T32 ES07247-15 (Richburg) 7/1/2003 – 6/30/2008 10%
NIH/NIEHS $197,435
Training in Molecular Toxicology and Environmental Disease

This is a training grant for support of six pre-doctoral trainees. Dr. Richburg serves as Director of this program.

•5T35 ES07307-09 (Richburg) 4/1/2002 – 3/31/2007 10%
NIH/NIEHS $74,623
Short-term Research Training for Minority Students

This grant is for support of summer research training of 10 minority undergraduate students. Dr. Richburg serves as Director of this program.

•P30 ES07784 (DiGiovanni) 4/1/2007 – 3/31/2012 5%
NIH/NIEHS
Mechanisms and Prevention of Environmental Disease

This grant is a NIEHS Center Grant of which Dr. Richburg is a center member and Associate Director.

•UT, Office of the Vice President for Research, Special Research Grant, (PI JH Richburg). 1/11/2007-8/31/2007, “Evaluation of the Functional Role of Fas/FasL and TRAIL/DR5 in the Testis of Pre-pubertal versus Adult Mice,” $750.

Pending Projects (Total direct costs)

•NIH/NIEHS, (PI JH Richburg, 25% effort). “Environmental Testicular Toxicants & Germ Cell Apoptosis.” (Competitive renewal of ES09145) $1,150,000 TDC.

PEER-REVIEWED PUBLICATIONS:

  1. Halleck, MM, Richburg, JH and Kauffman, FC (1992). Reversible and irreversible oxidant injury in PC12 cells by hydrogen peroxide. Free Radical Biology and Medicine 12:137-144.

  2. Zaleski, J, Richburg, JH and Kauffman, FC (1993). Preservation of the rate and profile of xenobiotic metabolism in rat hepatocytes stored in liquid nitrogen. Biochemical Pharmacology 46:111-116.

  3. Richburg, JH and Kauffman, FC (1994). Diisopropyl fluorophosphate inhibits receptor-activated Ca2+-influx in isolated rat hepatocytes. Toxicology and Applied Pharmacology 126: 178-185.

  4. Redenbach, DM, Richburg, JH and Boekelheide, K (1994). Microtubules with altered assembly kinetics have a decreased rate of kinesin-based transport. Cell Motility and the Cytoskeleton 27:79-87.

  5. Richburg, JH, Redenbach, DM and Boekelheide, K (1994). Seminiferous tubule fluid secretion is a Sertoli cell microtubule-dependent process inhibited by 2,5-hexanedione exposure. Toxicology and Applied Pharmacology 128:302-309.

  6. Richburg, JH and Boekelheide, K (1996). Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rats testes. Toxicology and Applied Pharmacology 137:42-50.

  7. Lee, J, Richburg, JH, Younkin, SC and Boekelheide, K (1997). The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138:2081-2088.

  8. Roberts, RA, Nebert, DW, Hickman, JA, Richburg, JH and Goldsworthy, TL (1997). Pertubation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology. Fundamental and Applied Toxicology 38:107-115.

  9. Boekelheide, K., Hall, SJ and Richburg, JH (1998). In vitro evaluation of Sertoli cell toxicants which target microtubules and decrease seminiferous tubule fluid formation. In vitro Toxicology 11:309-314.

  10. Boekelheide, K, Lee, J, Shipp, EB, Richburg, JH and Li, G (1998). Expression of Fas system-related genes in the testis during development and after toxicant exposure. Toxicology Letters 102-103:503-508.

  11. Lee, J, Richburg, JH, Shipp, EB, Meistrich, ML and Boekelheide, K (1999). The Fas system, a regulator of testicular germ cell apoptosis, is differentially upregulated in Sertoli cell. Versus germ cell injury of the testis. Endocrinology 140:852-858.

  12. Richburg, JH, Nañez, A and Gao, H (1999). Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes after exposure to mono-(2-ethylhexyl) phthalate (MEHP). Toxicology and Applied Pharmacology 160:271-278.

  13. Richburg, JH, Nañez, A, Williams, L, Younkin, S, Embree, M and Boekelheide, K (2000). Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a non-functional form of FasL. Endocrinology 141:787-793.

  14. Richburg, JH (2000). The relevance of spontaneous- and chemically-induced alterations in testicular germ cell apoptosis to toxicology. Toxicology Letters 112-113:79-86.

  15. Richburg, JH, Johnson, K, Schoenfeld, HA, Meistrich, ML and Dix, DJ (2002). Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicology Letters 135 (3): 167-183.

  16. Giammona, CJ, Sawhney, P, Chandrasekaran, Y and Richburg, JH (2002). Death receptor response in rodent testis after mono-(2-ethylhexyl) phthalate exposure. Toxicology and Applied Pharmacology, 185:119-127.

  17. Seaman FC, Sawhney, P, Giammona, CJ and Richburg, JH (2003). Cisplatin-induced pulse of germ cell apoptosis precedes long-term elevated apoptotic rates in C57/B6 mouse testis. Apoptosis. 8 (1):101-108.

  18. Richburg, JH and Nañez, A. (2003). Fas- or FasL-deficient mice display increased sensitivity to nitrobenzene-induced testicular germ cell apoptosis. Toxicology Letters. 139:1-10.

  19. Sawhney, P, Giammona, CJ, Meistrich, ML and Richburg, JH (2005). Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice. Journal of Andrology. 26:136-145.

  20. Chandrasekaran, Y and Richburg, JH (2005). The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP. Biology of Reproduction. 72: 206-213.

  21. Chandrasekaran, Y, McKee, CM, Ye, Y and Richburg, JH (2006). Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. Biology of Reproduction. 74: 560-568.

  22. Richburg, JH (2006). The role of death receptor signaling in testicular germ cell apoptosis triggered by mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury and its implications for risk assessment. Journal of Toxicology and Environmental Health, Part A. 69: 793-809.

  23. McKee, CM and Richburg, JH (2006). Testicular germ cell sensitivity to TRAIL-induced apoptosis is dependent on p53 expression and is synergistically enhanced by DR5 agonistic antibody treatment. Apoptosis. 11(12): 2237-50.

  24. Yao, P, Lin, Y, Sawhney, P, and Richburg, JH (2007). Transcriptional regulation of FasL expression and participation of sTNF-a in response to Sertoli cell injury. Journal of Biological Chemistry. 282:(8) 5420-5431.

  25. Yao, P, Lin, Y and Richburg, JH (2009). TNF-a-Mediated Disruption of Spermatogenesis in Response to Sertoli Cell Injury is Partially Regulated by MMP-2. Biology of Reproduction. 80: 581-589.

  26. Sinkevicius, KW, Laine, L, Lotan, TL, Woloszyn, K, Richburg, JH and Greene, GL (2009). Estrogen-dependent and -independent estrogen receptor a signaling separately regulate male fertility. Endocrinology. XXX:(X) XXX-XXX (submitted 7/08/08, accepted 1/23/09).

  27. Lin, Y-C, Yao, P-L, Cobarrubia, J and  Richburg, JH (2009). FasL and TRAIL gene-deficient mice show spermatogenic defects during the peri-pubertal period of testicular development. Reproduction. XXX:(X) XXX-XXX (in preparation).



BOOK CHAPTERS:
  1. Richburg, JH, Blanchard, KT and Boekelheide, K (1997). The Sertoli cell as a target for toxicants. In: Comprehensive Toxicology, Volume 10: Reproductive and Endocrine Toxicology, Section 1C: Mechanisms and Manifestations (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. 127-138.

  2. Boekelheide, K , Johnson, K, and Richburg, JH (2005). Sertoli Cell Toxicants. In: Sertoli Cell Biology, Chapter 20 (eds. Skinner, MK and Griswold, MD). Elsevier Academic Press, San Diego, CA. pp.345-382.

  3. Richburg, JH (xxxx). Male Reproductive Toxicology. In: Comprehensive Toxicology, Volume 11: Reproductive and Endocrine Toxicology, Section 1C: Mechanisms and Manifestations (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. xxx-xxx.

  4. Richburg, JH, and Cobarrubia, J (xxx). The Sertoli cell as a target for toxicants. In: Comprehensive Toxicology, Volume 11: Reproductive and Endocrine Toxicology, Section 1C: Mechanisms and Manifestations (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. xxx.

BOOK/VOLUME EDITOR:
  1. Richburg, JH, and Hoyer, P (volume editors) (XXX). Comprehensive Toxicology, Volume 11: Reproductive and Endocrine Toxicology (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. 127-138.
More information about Dr. Richburg
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> Lab Group
> Lab Alumni
> Return to Richburg's Home Page


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Last Reviewed: October 18, 2010

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


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