Student Information Training Programs Research Centers

Pharmacology & Toxicology

Research and Graduate Training Faculty


Richburg, John H., Ph.D.
Division Head, Professor of Pharm./Tox.
Gustavus & Louise Pfeiffer
Professorship in Toxicology
BME 3.510A

Representative Publications
Links may require institutional or personal subscriptions for access.
See also Google Scholar Publication Profile.

  1. Sawhney, P, Giammona, CJ, Meistrich, ML and Richburg, JH (2005). Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice. Journal of Andrology. 26:136-145.

  2. Chandrasekaran, Y and Richburg, JH (2005). The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP. Biology of Reproduction. 72: 206-213.

  3. Chandrasekaran, Y, McKee, CM, Ye, Y and Richburg, JH (2006). Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. Biology of Reproduction. 74: 560-568.

  4. Richburg, JH (2006). The role of death receptor signaling in testicular germ cell apoptosis triggered by mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury and its implications for risk assessment. Journal of Toxicology and Environmental Health, Part A. 69: 793-809.

  5. McKee, CM and Richburg, JH (2006). Testicular germ cell sensitivity to TRAIL-induced apoptosis is dependent on p53 expression and is synergistically enhanced by DR5 agonistic antibody treatment. Apoptosis. 11(12): 2237-50.

  6. Yao, P, Yi-Chen Lin, Y, Sawhney, P, and Richburg, JH (2007). Transcriptional regulation of FasL Expression and Participation of sTNF-a in response to Sertoli cell injury. Journal of Biological Chemistry. 282:(8) 5420-5431.

  7. Yao, P, Lin, Y and Richburg, JH (2009). TNF-a-Mediated Disruption of Spermatogenesis in Response to Sertoli Cell Injury is Partially Regulated by MMP-2. Biology of Reproduction. 80: 581-589.

  8. Sinkevicius, KW, Laine, L, Lotan, TL, Woloszyn, K, Richburg, JH and Greene, GL (2009). Estrogen-dependent and -independent estrogen receptor a signaling separately regulate male fertility. Endocrinology. 150:(6) 2898-2905.

  9. Yao, P-L, Lin Y-C and Richburg, JH (2009). MEHP-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP-2. Biology of Reproduction (X):XXX-XXX (Published on-online October 14, 2009 as DOI:10.1095/biolreprod.109.080374).

  10. Yao, P-L, Lin Y-C and Richburg, JH (2010). Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biology of Reproduction 82: (3) 516-527 (Epub 2009 Oct 14). PMCID: PMC2825170

  11. Lin, Y-C, Yao, P-L, and Richburg, JH (2010). FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicological Sciences Sciences 114:(2) 335-45 (Epub 2010 Jan 25). PMCID: PMC2840219

  12. Yao, P-L, Lin, Y-C and Richburg, JH (2011). Transcriptional suppression of Sertoli cell Timp2 in rodents following mono-(2-ethylhexyl) phthalate exposure is regulated by CEBPA and MYC. Biology of Reproduction: Published online before print August 10, 2011, doi: 10.1095/biolreprod.111.093484

  13. Yao, P-L, Lin, Y-C and Richburg, JH (2012). Mono-(2-ethylhexyl) phthalate promotes invasion and migration of human testicular embryonal carcinoma cells. Biology of Reproduction 86(5): 160, 1-10 PMCID: PMC3364929.

  14. Dwyer, JL and Richburg, JH (2012). Age-dependent alterations in spermatogenesis in Itchy mice. Spermatogenesis 2:(2) 104-116. PMCID: PMC3364791
Book Chapters
  • Richburg, JH, Blanchard, KT and Boekelheide, K (1997). The Sertoli cell as a target for toxicants. In: Comprehensive Toxicology, Volume 10: Reproductive and Endocrine Toxicology, Section 1C: Mechanisms and Manifestations (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. 127-138.

  • Boekelheide, K , Johnson, K, and Richburg, JH (2005). Sertoli Cell Toxicants. In: Sertoli Cell Biology , Chapter 20 (eds. Skinner, MK and Griswold, MD). Elsevier Academic Press, San Diego, CA. pp.345-382.

More information about Dr. Richburg
> CV (PDF)
> Lab Group
> Lab Alumni
> Return to Richburg's Home Page

Last Reviewed: October 14, 2012

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA

Email Address: pharmtox

Phone: 512-471-5158

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