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Pharmacology & Toxicology

Research and Graduate Training Faculty

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Richburg, John H., Ph.D.
Division Head, Professor of Pharm./Tox.
Gustavus & Louise Pfeiffer
Professorship in Toxicology
BME 3.510A
512-471-4736
john.richburg@austin.utexas.edu


Representative Publications
Links may require institutional or personal subscriptions for access.
See also Google Scholar Publication Profile.

  1. Sawhney, P, Giammona, CJ, Meistrich, ML and Richburg, JH (2005). Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice. Journal of Andrology. 26:136-145.

  2. Chandrasekaran, Y and Richburg, JH (2005). The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP. Biology of Reproduction. 72: 206-213.

  3. Chandrasekaran, Y, McKee, CM, Ye, Y and Richburg, JH (2006). Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. Biology of Reproduction. 74: 560-568.

  4. Richburg, JH (2006). The role of death receptor signaling in testicular germ cell apoptosis triggered by mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury and its implications for risk assessment. Journal of Toxicology and Environmental Health, Part A. 69: 793-809.

  5. McKee, CM and Richburg, JH (2006). Testicular germ cell sensitivity to TRAIL-induced apoptosis is dependent on p53 expression and is synergistically enhanced by DR5 agonistic antibody treatment. Apoptosis. 11(12): 2237-50.

  6. Yao, P, Yi-Chen Lin, Y, Sawhney, P, and Richburg, JH (2007). Transcriptional regulation of FasL Expression and Participation of sTNF-a in response to Sertoli cell injury. Journal of Biological Chemistry. 282:(8) 5420-5431.

  7. Yao, P, Lin, Y and Richburg, JH (2009). TNF-a-Mediated Disruption of Spermatogenesis in Response to Sertoli Cell Injury is Partially Regulated by MMP-2. Biology of Reproduction. 80: 581-589.

  8. Sinkevicius, KW, Laine, L, Lotan, TL, Woloszyn, K, Richburg, JH and Greene, GL (2009). Estrogen-dependent and -independent estrogen receptor a signaling separately regulate male fertility. Endocrinology. 150:(6) 2898-2905.

  9. Yao, P-L, Lin Y-C and Richburg, JH (2009). MEHP-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP-2. Biology of Reproduction (X):XXX-XXX (Published on-online October 14, 2009 as DOI:10.1095/biolreprod.109.080374).

  10. Yao, P-L, Lin Y-C and Richburg, JH (2010). Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biology of Reproduction 82: (3) 516-527 (Epub 2009 Oct 14). PMCID: PMC2825170

  11. Lin, Y-C, Yao, P-L, and Richburg, JH (2010). FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicological Sciences Sciences 114:(2) 335-45 (Epub 2010 Jan 25). PMCID: PMC2840219

  12. Yao, P-L, Lin, Y-C and Richburg, JH (2011). Transcriptional suppression of Sertoli cell Timp2 in rodents following mono-(2-ethylhexyl) phthalate exposure is regulated by CEBPA and MYC. Biology of Reproduction: Published online before print August 10, 2011, doi: 10.1095/biolreprod.111.093484

  13. Yao, P-L, Lin, Y-C and Richburg, JH (2012). Mono-(2-ethylhexyl) phthalate promotes invasion and migration of human testicular embryonal carcinoma cells. Biology of Reproduction 86(5): 160, 1-10 PMCID: PMC3364929.

  14. Dwyer, JL and Richburg, JH (2012). Age-dependent alterations in spermatogenesis in Itchy mice. Spermatogenesis 2:(2) 104-116. PMCID: PMC3364791
Book Chapters
  • Richburg, JH, Blanchard, KT and Boekelheide, K (1997). The Sertoli cell as a target for toxicants. In: Comprehensive Toxicology, Volume 10: Reproductive and Endocrine Toxicology, Section 1C: Mechanisms and Manifestations (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. 127-138.

  • Boekelheide, K , Johnson, K, and Richburg, JH (2005). Sertoli Cell Toxicants. In: Sertoli Cell Biology , Chapter 20 (eds. Skinner, MK and Griswold, MD). Elsevier Academic Press, San Diego, CA. pp.345-382.

More information about Dr. Richburg
> CV (PDF)
> Lab Group
> Lab Alumni
> Return to Richburg's Home Page


Last Reviewed: October 14, 2012

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


Erickson Authors New Book

"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.

> Read more about Dr. Erickson's new book.


Gore receives SEBM award

Andrea Gore is named to the SEBM Distinguished Scientist Award.

> Read more about Dr. Gore's new award.

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