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Pharmacology & Toxicology

Research and Graduate Training Faculty
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Richburg, John H., Ph.D.
Division Head, Associate Professor
Wm. I. Dismukes Fellow
PHR 5.218C
512-471-4736
john_richburg@mail.utexas.edu

Representative Publications
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  1. Sawhney, P, Giammona, CJ, Meistrich, ML and Richburg, JH (2005). Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice. Journal of Andrology. 26:136-145.

  2. Chandrasekaran, Y and Richburg, JH (2005). The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP. Biology of Reproduction. 72: 206-213.

  3. Chandrasekaran, Y, McKee, CM, Ye, Y and Richburg, JH (2006). Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. Biology of Reproduction. 74: 560-568.

  4. Richburg, JH (2006). The role of death receptor signaling in testicular germ cell apoptosis triggered by mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury and its implications for risk assessment. Journal of Toxicology and Environmental Health, Part A. 69: 793-809.

  5. McKee, CM and Richburg, JH (2006). Testicular germ cell sensitivity to TRAIL-induced apoptosis is dependent on p53 expression and is synergistically enhanced by DR5 agonistic antibody treatment. Apoptosis. 11(12): 2237-50.

  6. Yao, P, Yi-Chen Lin, Y, Sawhney, P, and Richburg, JH (2007). Transcriptional regulation of FasL Expression and Participation of sTNF-a in response to Sertoli cell injury. Journal of Biological Chemistry. 282:(8) 5420-5431.

  7. Yao, P, Lin, Y and Richburg, JH (2009). TNF-a-Mediated Disruption of Spermatogenesis in Response to Sertoli Cell Injury is Partially Regulated by MMP-2. Biology of Reproduction. 80: 581-589.

  8. Sinkevicius, KW, Laine, L, Lotan, TL, Woloszyn, K, Richburg, JH and Greene, GL (2009). Estrogen-dependent and -independent estrogen receptor a signaling separately regulate male fertility. Endocrinology. XXX:(X) XXX-XXX (published ahead of print March 5, 2009 as doi:10.1210/en.2008-1016).
Book Chapters
  • Richburg, JH, Blanchard, KT and Boekelheide, K (1997). The Sertoli cell as a target for toxicants. In: Comprehensive Toxicology, Volume 10: Reproductive and Endocrine Toxicology, Section 1C: Mechanisms and Manifestations (eds. Sipes, IG, McQueen, CA, and Gandolfi, AJ). Elsevier Science LTD., Oxford, UK. pp. 127-138.

  • Boekelheide, K , Johnson, K, and Richburg, JH (2005). Sertoli Cell Toxicants. In: Sertoli Cell Biology , Chapter 20 (eds. Skinner, MK and Griswold, MD). Elsevier Academic Press, San Diego, CA. pp.345-382.

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Last Reviewed: April 21, 2009

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
1 University Station,
A1915
Austin, TX
78712-0125
USA

Email Address: pharmacy
@www.utexas.edu

Phone: 512-471-5158


Gore Receives $841,000 Gramt

Dr. Andrea Gore has received an NIH grant to study transgenerational effects of environmental contaminants.

> Read more about this grant.