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Pharmacology & Toxicology

Research and Graduate Training Faculty

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Van Den Berg, Carla, Pharm.D.
Associate Professor of Pharm./Tox.
DPI 2.208
512-471-5199
carla.vandenberg@austin.utexas.edu


Publications & Abstracts

Articles

1. Van Den Berg, C., McGill, J.R., Kuhn, J.G., Walsh, J.T., De La Cruz, P.S., Davidson, K.K., Wahl, G.M., Von Hoff, D.D. Pharmacokinetics of hydroxyurea in nude mice. Anti-Cancer Drugs 1994; 5: 573-8.

2. Weiss, G.R., Kuhn, J.G., Rizzo, J., Smith, L.S., Rodriguez, G.I., Eckardt, J., Burris, H.A., III, Fields, S., Van Den Berg, K., Von Hoff, D.D. A phase I and pharmacokinetics study of 2-chlorodeoxyadenosine in patients with solid cancers. Cancer Chemother Pharmacol 1994; 35: 397-402.

3. Van Den Berg, C., Guan, X-Y, Von Hoff, D., Jenkins, R., Bittner, M., Griffin, C., Kallonemi, O., Visakorpi, T., McGill J., Hearth, J., Epstein, J., Sarosdy, M., Meltzer, P., Trent, J. DNA sequence amplification in human prostate cancer identified by chromosome microdissection: Potential prognostic implications. Clinical Cancer Res 1994; 1: 11-18.

4. Koeller, J.M., Van Den Berg, C.L. Anemias. In: Yee Young L, Koda-Kimble MA, eds. Applied Therapeutics. 6th ed. Vancouver:Applied Therapeutics; 1995:88-1-17.

5. Van Den Berg, C.L., von Hoff, D.D. "Use of hydroxyurea to alter drug resistance of human tumor cells" In: Mugia FM, ed., Chemotherapy: concepts, mechanisms, and disease targets. Kluwer Academic Publishers; 1995:95-114.

6. Yee, D., Van Den Berg, C., Kozelsky, T.W., Kuhn, J.G., Cox, G.N. Pharmacokinetic profile of recombinant human insulin-like growth factor binding protein-1 in athymic mice. Biomedicine & Pharmacotherapy 1996; 50: 154-157.

7. Van Den Berg, C.L., Kuhn, J.G., Hilsenbeck, S., Cox, G.N., Yee, D. Insulin-like growth factor binding protein-1 (rhIGFBP-1) inhibits growth of breast cancer in athymic mice. Eur Jnl Cancer 1997; 33: 1108-1113.

8. Rocha, R.L., Hilsenbeck, S.G., Jackson, J.G., Van Den Berg, C.L., Weng, C-N, Lee, A.V., Yee, D. Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free. Clinical Cancer Research 1997; 3:103-109.

9. Gooch, J.L., Van Den Berg, C.L., Yee, D. Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death- proliferative and anti-apoptotic effects. Breast Cancer Research and Treatment 1999; 56:1-10.

10. Van Den Berg, C., O'Bryant C. Anemias. In: Yee Young L, Koda-Kimble MA, Young L., eds. Applied Therapeutics: The Clinical Use of Drugs. 7th ed. Philadelphia, Lippincott Williams and Wilkins; 2001:84-1-21.

11. Mamay, C.L., Sion, A.M., Wolf, D.M., Molina, D.M., Van Den Berg, C.L. An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. Oncogene 2003; 22:602-614.

12. Ferguson, H.A., Marietta, P.M. Van Den Berg, C.L. UV induced apoptosis is mediated independent of caspase-9 in MCF-7 cells- a model for cytochrome C resistance. Journal of Biological Chemistry, 2003; 278:45793-45800.

13. Van Den Berg, C.L. IGF-I influence on breast cancer cell survival. Invited review. Breast Diseases, 2003; 17:49-59.

14. Mingo-Sion, A.M., Marietta, P.M. Koller, E., Van Den Berg, C.L. Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation and apoptosis in breast cancer cells. Oncogene 2004; 23:596-604.

15. Mingo-Sion, A.M., Koller, E., Reyland, M.E., Van Den Berg, C.L. mTOR and PKCd interact to regulate stress and ligand mediated phosphorylation of IRS-1 Ser312 in breast cancer cells. Breast Cancer Research and Treatment 2005; 91:259-269.

16. Ferguson, H.A. Mingo-Sion, A.M., Koller, E., Knudsen, E.S., Van Den Berg, C.L... Mammalian Target of Rapamycin mediates Insulin-like Growth Factor breast cancer survival through phosphorylation of Retinoblastoma. In preparation.

Abstracts:

1. McGill, J., Meador, R.J., Davidson, K.K., Walsh, J.T., Van Den Berg, C.L., Leal, B.Z., Von Hoff, D.D. Evidence of unstable gene amplification in human ovarian cancer cells. Presented at the 5th Intl. Workshop on Chromosomes in Solid Tumors, Tuscon, AZ, Jan 10-12, 1993.

2. Van Den Berg, C.L., Fields, S.M., Freytes, C.O., LeMaistre, C.F., Koeller, J.M. Clinical outcomes of low-dose granulocyte-colony stimulating factor (G-CSF) in bone marrow transplant (BMT) patients. Proceedings of 4th Intl Symposium Supportive Care in Cancer. OLMA-Messen Conference Centre, St. Gallen, Switzerland, February 24-27, 1993.

3. McGill, J.R., Walsh, J., Durak, M., Van Den Berg, C.L., Segura, L., Von Hoff, D. Unstable gene amplification found in breast cancers taken directly from patients. Proc Am Assoc Cancer Res, 34:129, 1993.

4. Van Den Berg, C.L., McGill, J.R., Von Hoff, D.D. Amplified copies of c-myc occur in both extrachromsomal and intrachromosomal sites of a glioblastoma multiforme cell line. Proc Am Assoc Cancer Res, 34:389, 1993.

5. Van Den Berg, C., McGill, J., Kuhn, J., Walsh, J., De La Cruz, P., Davidson, K., Von Hoff, D. Hydroxyurea pharmacokinetics in nude mice. Proc. Am. Assoc. Cancer Res. 35:428, 1994.

6. McGill, J.R., Mattern, V., Van Den Berg, C.L., Beitzel, B.F., Chang, D., Dai, A. Hodge, J., Eckhardt, S.G. Mapping and characterization of a microdissected colon cancer double minute chromosome. Proc. Am. Assoc. Cancer Res. 36:540, 1995.

7. Van Den Berg, C.L., McDermott, M.J., Stroh, C.A., Reitz, B., Cox, G.N., Yee, D. Insulin-like growth factor binding protein-1 (rhIGFBP-1) inhibits growth of breast cancer in vivo. Breast Cancer Res Treat, 37:104 (Supp),1995.

8. Van Den Berg, C.L., Yee, D. Insulin-like growth factor I (IGF-I) enhances MCF-7 cell growth even in the presence of adriamycin and taxol. Proc Am Assoc Cancer Res 37:220, 1996.

9. Gooch J.L., Van Den Berg, C.L., Yee D. Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-mediated cell death; proliferative and anti-apoptotic effects. Breast Cancer Research and Treatment 50: 273, 1998.

10. Van Den Berg, C.L., Mamay C., Molina, M. Mechanisms of Insulin-like growth factor-I (IGF-I) chemoprotective effect in MCF-7 breast cancer cells. Breast Cancer Research and Treatment 50: 274, 1998.

11. Van Den Berg, C.L., Mamay C., Molina, M. Mechanisms of Insulin-like growth factor-I (IGF-I) chemoprotective effect in MCF-7 breast cancer cells. Proc Am Assoc Cancer Res 41:406, 2000.

12. Van Den Berg, C.L., Sion, A., Mamay, C.L. Molecular targets for IGF-I protection of irradiated breast cancer cells. Era of Hope. Department of Defense Breast Cancer Research Program Meeting P36-17, 2002.

13. Ferguson, H.A., Marietta, P.M., Van Den Berg, C.L. UV-induced apoptosis occurs independently of the apoptosome in MCF-7 breast cancer cells. Molecular Mechanisms of Apoptosis, Keystone Symposia 2003; 164.

14. Mingo-Sion, A.M. Koller, E., Van Den Berg, C.L. Mammalian target of rapamycin predominantly regulates insulin receptor substrate-1 Ser312 phosphorylation in breast cancer cells. Invited Podium Presentation: Protein Kinases and Cancer: The Promise of Molecular-Based Therapies Keystone Symposia 2004; 216.


More information about Dr. Van Den Berg
> CV
> Grants & Patents
> Drug Dynamics Institute
> Return to Van Den Berg's Home Page


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Last Reviewed: May 20, 2008

Division Information

Mailing Address:
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
at Austin
107 W. Dean Keeton
Stop C0875
Austin, TX, USA
78712

Email Address: pharmtox
@austin.utexas.edu

Phone: 512-471-5158


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