My research program is focused on studying the contribution of inflammatory signaling to the develop-ment and progression of autoimmune diseases, including hematological malignancies. Specifically, we focus on the regulatory mechanisms of two transcription factors that play a role in promoting cancer and autoimmunity, nu-clear factor-kappaB (NF-kB) and the aryl hydrocarbon receptor (AHR). Our goal is to better understand how the signaling pathways that activate these transcription factors are regulated on a molecular level in order to identify possible therapeutic targets for the myriad immunological disorders that arise from deregulated signaling.
Pharmacology & Toxicology
College of Pharmacy
The University of Texas
107 W. Dean Keeton
Austin, TX, USA
Email Address: pharmtox
Dr. Som Mukhopad-
hyay led the research team that focused on the gene SLC30A10 and its role as a "door opener" in helping to remove elevated levels of manganese from cells. The study was published in the Oct. 15, 2014 issue of The Journal of Neuroscience.
"Drugs, the Brain and Behavior" is co-authored by Dr. Carlton Erickson, the college's associate dean for research and graduate studies, and Dr. John Brick, executive director of Intoxikon International.
Andrea Gore is named to the SEBM Distinguished Scientist Award.