John H. Richburg, Professor of Toxicology; Head, Division of Pharmacology & Toxicology; The University of Texas at Austin; Austin, Texas 78712; (T) (512) 471-4736 (FAX) 471-5002; email: john_richburg@mail.utexas.edu
Director, NIEHS Toxicology Training Grant
1. The mechanisms of testicular injury culminating in germ cell death after exposure to environmental toxicants.
2. Mechanisms of both physiologic and toxicant-induced germ cell death in the testis.
3. Investigation of the primary target of the active phthalic acid ester MEHP in Sertoli cells.

Mark T. Bedford, Associate Professor of Experimental Carcinogenesis, The University of Texas, M.D. Anderson Cancer Center; Science Park - Research Division, P.O. Box 389, Smithville, Texas 78957; (T) (512) 237-9539 (FAX) (512) 237-2475; email: mbedford@mdanderson.org
1. Arginine methylation.
2. WW domains.
3. Protein-protein interactions.
4. Gene targeting.

Shawn Bratton, Associate Professor of Toxicology, The University of Texas at Austin; Division of Pharmacology & Toxicology; Austin, Texas 78712; (T) (512) 471-1735 (FAX) (512) 471-5002; email: sbbratton@mail.utexas.edu
1. Basic mechanisms of apoptosis.
2. Caspase activation and modulation.
3. Mechanisms by which inhibitor-of-apoptosis proteins prevent or potentiate apoptosis.

John DiGiovanni, Professor of Carcinogenesis & Coulter R. Sublett Chair, PHR 3.208E & DPRI 2.228, 1400 Barbara Jordan Blvd., Austin, TX 78723; (T) (512) 495-4726; email: jdigiovanni@mail.utexas.edu
1. Identifying critical targets (cellular, biochemical, and molecular) involved in both the initiation and promotion stages of chemical carcinogenesis.
2. Transgenic models.
3. Growth factors and signal transduction.

Susan M. Fischer, Professor of Experimental Carcinogenesis, The University of Texas, M. D. Anderson Cancer Center; Science Park - Research Division, P. O. Box 389, Smithville, Texas 78957; (T) (512) 237-9482 (FAX) 237-2437; email: smfischer@mdanderson.org
1. Multistage chemical carcinogenesis, with particular emphasis on the promotion stage.
2. Elucidate the function and regulation of the enzymes involved in arachidonic acid metabolism in skin.
3. Develop dietary and other approaches to skin cancer prevention.

Robin Fuchs-Young, Associate Professor of Experimental Carcinogenesis, The University of Texas, M.D. Anderson Cancer Center; Science Park - Research Division, P.O. Box 389, Smithville, Texas 78957; (T) (512) 237-9547 (FAX) (512) 237-2437; email: rfyoung@mdanderson.org
1. Mammary development and tumorigenesis.
2. Uterine Tumors.
3. Steroid hormone action.
4. Hormonal carcinogenesis.

Andrea C. Gore, Professor of Pharmacology, The University of Texas at Austin; Division of Pharmacology & Toxicology; Austin, Texas 78712; (T) (512) 471-3669 (FAX) 471-5002; email: andrea.gore@mail.utexas.edu
1. Neural mechanisms of reproductive development and puberty.
2. Effects of environmental and hormonal factors that perturb reproductive function.
3. Neural mechanisms for reproductive senescence.

Stephen D. Hursting, Professor of Nutritional Sciences, The University of Texas at Austin; Division of Nutrition; Austin, Texas 78712; (T) (512) 471-2809 (FAX) 471-5844; email: shursting@mail.utexas.edu
1. Diet-gene interactions relevant to cancer prevention.
2. Molecular and hormonal mechanisms underlying energy balance-cancer associations.

David G. Johnson, Associate Professor of Experimental Carcinogenesis, The University of Texas, M.D. Anderson Cancer Center; Science Park - Research Division, P.O. Box 389, Smithville, Texas 78957; (T) (512)237-9511 (FAX) (512) 237-2437; email: djohnson@mdanderson.org
1. E2F transcription factors.
2. Cell cycle.
3. Tumor suppressor genes.
4. Oncogenes.

Kimberly Kline, Professor of Nutritional Sciences, The University of Texas at Austin; Division of Nutrition; Austin, Texas 78712; (T) (512) 471-8911 (FAX) 471-5844; email: k.kline@mail.utexas.edu
1. Interdisciplinary areas of nutrition and cancer biology.
2. Better understanding of the biological actions of vitamin E and naturally occurring and synthetic derivatives of vitamin E.
3. Understanding of growth inhibitory signaling pathways resulting in apoptosis and DNA synthesis arrest.

Edward Mills, Associate Professor of Toxicology, The University of Texas at Austin; Division of Pharmacology & Toxicology; Austin, Texas 78712; (T) (512) 471-6699 (FAX) (512) 471-5002; email: ted_mills@mail.utexas.edu
1. Understanding how mitochondria talk to other cellular components.
2. How mitochondria participate in the pharmacologic and toxic actions of chemicals in disease processes.

Bob G. Sanders, Professor of Zoology, The University of Texas at Austin, Department of Zoology, Austin, Texas 78712; (T) (512) 471-7441 (FAX) 471-9651; email: bgsanders@mail.utexas.edu
1. Genetics and biology of cancer development and control.
2. Mechanisms of chemotherapeutic induction of apoptosis and DNA synthesis arrest.
3. Immune targeting of toxins via monoclonal antibody and phage displayed single heavy and light chain specificity fragments.

Dean Tang, Professor of Experimental Carcinogenesis, The University of Texas, M. D. Anderson Cancer Center; Science Park - Research Division, P. O. Box 389, Smithville, Texas 78957; (T) (512) 237-9575 (FAX) (512) 237-2475; email: dtang@mdanderson.org
1. Apoptosis.
2. Stem cells and cancer stem cells.
3. Prostate Cancer.

Peter Thomas, Professor of Zoology and Marine Science, The University of Texas at Austin; Marine Science Institute; Port Aransas, Texas 78373; (T) (361) 749-6768; email: peter.thomas@mail.utexas.edu
1. Reproductive endocrine toxicology.
2. Mechanisms of endocrine disruption by xenobiotic chemicals.
3. Environmental toxicology or aquatic organisms.

Carla Van Den Berg, Associate Professor of Toxicology, The University of Texas at Austin; Division of Pharmacology & Toxicology; Austin, Texas 78712; (T) (512) 471-5199 (FAX) (512) 475-6088; email: cvandenberg@mail.utexas.edu
1. Role of growth factor-mediated treatment resistance in breast cancer.

Karen Vasquez, Professor of Experimental Carcinogenesis, Coulter R. Sublett Fellow, BME 3.510F & DPRI 2.214, 1400 Barbara Jordan Blvd,. Austin, TX 78723 ; email: karen.vasquez@austin.utexas.edu
1. Elucidate the molecular mechanisms of DNA damage recognition by DNA repair and recombination pathways.
2. Develop triplex technology to modify mammalian gene structure and function.
3. Study the role of DNA structure in genomic instability and mutagenesis.

Cheryl L. Walker, Professor of Experimental Carcinogenesis, The University of Texas, M. D. Anderson Cancer Center; Science Park - Research Division, P. O. Box 389, Smithville, Texas 78957; (T) (512) 237-9550 (FAX) 237-2475; email: chwalker@mdanderson.org
1. Identify critical target genes for carcinogens and elucidate the role of these genetic alterations in the process of tumor development.
2. Testing a variety of pharmaceutical agents for their ability to inhibit the growth of transformed kidney epithelial and uterine myometrical cells.
3. Identify autocrine growth factors for rat mesothelioma.